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Excitation-inhibition imbalance links amyloid pathophysiology to cognition in non-demented individuals.

Code ↔ Paper

2 matches between paragraphs of the paper and lines of its authors' code, computed by the harvester (lexical-v1). Click a colored paragraph or line to see its counterpart.

The 2 matches · 1 of them tie a paragraph to a whole file without given lines: a weak match, whose lines are not tinted
  1. [1] § METHODS › Alzheimer's Disease Neuroimaging Initiative dataset ↔ stable_projects/disorder_subtypes/Zhang2016_ADFactors/step3_analyses_internalUse/functions/CBIG_get_mmse.m, the whole file · a weak match · score 0.58 · MMSE score, ADNI GO, Dementia · Report a mismatch
  2. [2] § METHODS › Parametric feedback inhibition control model ↔ stable_projects/fMRI_dynamics/Kong2021_pMFM/part2_pMFM_control_analysis/Primary_gradients/scripts/CBIG_pMFM_basic_functions.py, lines 17 to 112 · score 0.55 · noise amplitude, structural connectome, gradient, neural, strengths, activity · Report a mismatch

Paper

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The authors' code

MATLAB · 138 lines · 5.3 KB · MIT · 1 match

  1. function mmse = CBIG_get_mmse(rid_of_interest, predementedOnly)
  2. % mmse = CBIG_get_mmse(rid_of_interest, predementedOnly)
  3. % Fetch MMSE scores from .csv files
  4. %
  5. % Input:
  6. % - rid: the RID's of subjects of interest
  7. %
  8. % Output:
  9. % - mmse: 1st col is RID, 2nd is VISCODE, 3rd is EXAMDATE, 4th is score
  10. %
  11. % Written by CBIG under MIT license: https://github.com/ThomasYeoLab/CBIG/blob/master/LICENSE.md
  12. % Read MMSE.csv
  13. file_id = fopen('//share/users/imganalysis/yeolab/data/ADNI_mert/scripts/MMSE.csv', 'r');
  14. data = textscan(file_id, ...
  15. '%*q %*q %q %*q %*q %q %*q %*q %q %*q %*q %*q %*q %*q %*q %*q %*q %*q %*q %*q %*q %*q %*q %*q %*q %*q %*q %*q %*q %*q %*q %*q %*q %*q %*q %*q %*q %*q %*q %*q %*q %*q %*q %*q %*q %*q %*q %*q %*q %*q %*q %*q %*q %*q %*q %*q %q %*[^\n]',...
  16. 'delimiter', {',', '\n'}, 'HeaderLines', 1); % read in RID, PTGENDER, and PTDOBYY
  17. fclose(file_id);
  18. data = [data{1, 1} data{1, 2} data{1, 3} data{1, 4}];
  19. % Certain RID only
  20. rid_col = cellfun(@str2num, data(:, 1));
  21. keep_ind = ismember(rid_col, rid_of_interest);
  22. data_rid = data(keep_ind, :);
  23. % Remove those without a score
  24. keep_ind = ones(size(data_rid, 1), 1);
  25. for idx = 1:numel(keep_ind)
  26. if strcmp(data_rid{idx, 4}, '') % empty score
  27. keep_ind(idx) = 0;
  28. end
  29. end
  30. data_rid = data_rid(logical(keep_ind), :);
  31. %-------------- Some subjects' VISCODE are missing
  32. %%% Sol 1 - reference back to REGISTRY.csv
  33. disp('Missing ADNI GO/2 dates -> reference back to REGISTRY.csv');
  34. file_id = fopen('//share/users/imganalysis/yeolab/data/ADNI_mert/scripts/REGISTRY.csv', 'r');
  35. data = textscan(file_id, ...
  36. '%*q %*q %q %*q %*q %q %*q %*q %*q %*q %*q %q %*[^\n]', ...
  37. 'delimiter', {',', '\n'}, 'HeaderLines', 1);
  38. fclose(file_id);
  39. data = [data{1, 1} data{1, 2} data{1, 3}];
  40. for idx = 1:size(data_rid, 1)
  41. if strcmp(data_rid{idx, 3}, '') % empty EXAMDATE
  42. rid = data_rid{idx, 1};
  43. viscode = data_rid{idx, 2};
  44. missing_idx = logical(ismember(data(:, 1), rid)&ismember(data(:, 2), viscode));
  45. % Fill it up!
  46. data_rid{idx, 3} = data{missing_idx, 3};
  47. end
  48. end
  49. % Also unavailable in REGISTRY.csv? Discard!
  50. keep_ind = ones(size(data_rid, 1), 1);
  51. for idx = 1:numel(keep_ind)
  52. if strcmp(data_rid{idx, 3}, '') % empty examdate
  53. keep_ind(idx) = 0;
  54. end
  55. end
  56. data_rid = data_rid(logical(keep_ind), :);
  57. % %%% Sol 2 - add an approximate date estimated from VISCODE
  58. % disp('Missing ADNI GO/2 dates -> estimate from VISCODE');
  59. % for idx = 1:size(data_rid, 1)
  60. % if strcmp(data_rid{idx, 3}, '') % empty EXAMDATE
  61. % rid = data_rid{idx, 1};
  62. % sc_idx = logical(ismember(data_rid(:, 1), rid)&ismember(data_rid(:, 2), 'sc'));
  63. % sc_date_str = data_rid{sc_idx, 3};
  64. % sc_date = datenum(sc_date_str, 'yyyy-mm-dd');
  65. % viscode = data_rid{idx, 2};
  66. % months = strsplit(viscode, 'm');
  67. % days = str2double(months{1, 2})*30;
  68. % examdate = sc_date+days;
  69. % examdate_str = datestr(examdate, 'yyyy-mm-dd');
  70. % data_rid{idx, 3} = examdate_str;
  71. % end
  72. % end
  73. % %%% Sol 3 - just remove them
  74. % disp('Missing ADNI GO/2 dates -> just discard');
  75. % keep_ind = ones(size(data_rid, 1), 1);
  76. % for idx = 1:numel(keep_ind)
  77. % if strcmp(data_rid{idx, 3}, '') % empty EXAMDATE
  78. % keep_ind(idx) = 0;
  79. % end
  80. % end
  81. % data_rid = data_rid(logical(keep_ind), :);
  82. % Sort by RID
  83. data_rid_sort = data_rid;
  84. rid_col = cellfun(@str2num, data_rid(:, 1));
  85. viscode_col = data_rid(:, 2);
  86. examdate_col = data_rid(:, 3);
  87. score_col = cellfun(@str2num, data_rid(:, 4));
  88. [rid_col_sort, sort_ind] = sort(rid_col);
  89. score_col_sort = score_col(sort_ind);
  90. data_rid_sort(:, 1) = num2cell(rid_col_sort);
  91. data_rid_sort(:, 2) = viscode_col(sort_ind);
  92. data_rid_sort(:, 3) = examdate_col(sort_ind);
  93. data_rid_sort(:, 4) = num2cell(score_col_sort);
  94. % Remove -1 scores
  95. data_rid_sort = data_rid_sort(score_col_sort>=0, :);
  96. mmse = data_rid_sort;
  97. % Only want pre-dementia scores
  98. if predementedOnly == 1
  99. disp('Use only the pre-dementia data');
  100. predementia_ind = ones(size(mmse, 1), 1);
  101. rid_date_age = get_convDate_convAge(rid_of_interest);
  102. % Loop thru all convert dates
  103. for idx = 1:size(rid_date_age, 1)
  104. rid = rid_date_age{idx, 1};
  105. convDate = rid_date_age{idx, 2};
  106. % RID matched & date > convDate, already demented, so predementia_ind set to 0
  107. predementia_ind(ismember(cell2mat(mmse(:, 1)), rid)&(datenum(mmse(:, 3), 'yyyy-mm-dd')>=datenum(convDate))) = 0;
  108. end
  109. mmse = mmse(logical(predementia_ind), :);
  110. % Only want post-dementia scores
  111. % Truncate at conversion
  112. elseif predementedOnly == -1
  113. disp('Use only the post-dementia data');
  114. postdementia_ind = ones(size(mmse, 1), 1);
  115. rid_date_age = get_convDate_convAge(rid_of_interest);
  116. % RID not even matched, never convereted, so postdementia_ind set to 0
  117. postdementia_ind(~ismember(cell2mat(mmse(:, 1)), cell2mat(rid_date_age(:, 1)))) = 0;
  118. % Loop thru all convert dates
  119. for idx = 1:size(rid_date_age, 1)
  120. rid = rid_date_age{idx, 1};
  121. convDate = rid_date_age{idx, 2};
  122. % RID matched & date < convDate, not demented yet, so postdementia_ind set to 0
  123. postdementia_ind(ismember(cell2mat(mmse(:, 1)), rid)&(datenum(mmse(:, 3), 'yyyy-mm-dd')<datenum(convDate))) = 0;
  124. end
  125. mmse = mmse(logical(postdementia_ind), :);
  126. else
  127. disp('Use all the data we have');
  128. end
  129. end

CBIG_get_mmse.m at commit 634f676, under MIT · at the source

Overview

Authors: Shaoshi Zhang1,2,3,4,5, Sebastian N Roemer‐Cassiano6,7, Joyce Ruifen Chong8,9,10, Tian Fang1,2,3, Yan Li10, Ziwen Wang1,2,3, Tianchu Zeng1,2,3,4, Xin Li1,2,3,11, Gustavo Deco12,13, Narayanaswamy Venketasubramanian14, Juan Helen Zhou1,2,3,4,5, Christopher Li‐Hsian Chen10, Alzheimer's Disease Neuroimaging Initiative, Mitchell K P Lai9, Nicolai Franzmeier6,15,16, B T Thomas Yeo1,2,3,4,5,17
17 affiliations
  1. Centre for Sleep & Cognition & Centre for Translational Magnetic Resonance Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
  2. Department of Medicine, Healthy Longevity Translational Research Programme, Human Potential Translational Research Programme & Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
  3. N.1 Institute for Health & Institute for Digital Medicine, National University of Singapore, Singapore, Singapore
  4. Department of Electrical and Computer Engineering, National University of Singapore, Singapore, Singapore
  5. Integrative Sciences and Engineering Programme (ISEP), National University of Singapore, Singapore, Singapore
  6. Institute for Stroke and Dementia Research, LMU Munich, Munich, Germany
  7. Department of Neurology, LMU Hospital, LMU Munich, Munich, Germany
  8. Wisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health, University of Wisconsin–Madison, Madison, Wisconsin, USA
  9. Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
  10. Memory, Ageing and Cognition Centre, Departments of Pharmacology and Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
  11. Aging Research Center, Karolinska Institute and Stockholm University, Stockholm, Sweden
  12. Center for Brain and Cognition, Department of Technology and Information, Universitat Pompeu Fabra, Barcelona, Spain
  13. Institució Catalana de la Recerca i Estudis Avançats, Universitat Barcelona, Barcelona, Spain
  14. Raffles Neuroscience Centre, Raffles Hospital, Singapore, Singapore
  15. Munich Cluster for Systems Neurology (SyNergy), Munich, Germany
  16. Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, The Sahlgrenska Academy, Gothenburg, Sweden
  17. Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, USA
Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association, volume 22, issue 10, article e71891
Dates: received 28 May 2026; accepted 7 September 2026; published online 30 September 2026; in print October 2026
Type: Research article · Language: English
License: CC BY
Identifiers: DOI 10.1002/alz.71891 · PMID 42811946 · PMCID PMC13624711 · OpenAlex W7214979065
Open access: hybrid, a free copy (OpenAlex)
Status: code verified (how the code is found and verified)
Categories: human (organism), Alzheimer's / dementia (population), cognitive (subfield)
Methods: Statistics, fMRI & imaging, Connectivity
Keywords: Alzheimer's disease, amyloid beta, amyloid pathophysiology, biomarkers, biophysical modeling, cognition, plasma phosphorylated tau
MeSH: Amyloid beta-Peptides*, Brain*, Cognition*, Aged, Alzheimer Disease, Biomarkers, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Peptide Fragments, Phosphorylation, tau Proteins (* major topic)
Topic: Functional Brain Connectivity Studies (Cognitive Neuroscience, Neuroscience), according to OpenAlex
Funding: NMRC OF-IRG (OFIRG24jan-0006, OFIRG24jul-0049); NMRC CTG-IIT (CTGIIT23jan-0001); United States National Institutes of Health (R01MH133334, 2R01MH120080); Singapore National Medical Research Council (NMRC) LCG (OFLCG19May-0035); NMRC STaR (STaR20nov-0003); Singapore National Research Foundation (NRF) Investigatorship (NRFI10-2024-0014); Singapore Ministry of Health (MOH) Centre Grant (CG21APR1009); NUS Yong Loo Lin School of Medicine (NUHSRO/2020/124/TMR/LOA)
Citations: not cited yet (Europe PMC); 96 references in the paper

Abstract

INTRODUCTION: Excitation–inhibition (E/I) imbalance has been proposed as an early circuit‐level mechanism in Alzheimer's disease (AD), but its relationship to molecular pathology and cognition in humans remains unclear.

METHODS: We integrated biophysical modeling of resting‐state functional magnetic resonance imaging with cerebrospinal fluid (CSF) and plasma biomarkers to examine whether E/I ratio links amyloid pathophysiology to memory in non‐demented individuals across two cohorts from North America (N = 302; CSF amyloid beta 42 [Aβ42]) and Singapore (N = 240; plasma phosphorylated tau 217 [p‐tau217]).

RESULTS: Elevated E/I ratio was associated with lower CSF Aβ42 and higher plasma p‐tau217, with greater sensitivity in sensory–motor regions. In contrast, elevated E/I ratio in association cortices was more strongly related to worse memory function. Mediation analyses indicated E/I ratio partially accounted for the AD biomarker–memory relationship.

DISCUSSION: E/I imbalance represents an intermediate, systems‐level circuit mechanism that links AD pathophysiology to cognitive impairment, offering novel insight into early neurophysiological changes along the AD continuum.

Reproduced under the paper's license (CC BY), from the paper cited above.

Repositories

Its files are read in the Code ↔ Paper reader above, with 2 matches between paragraphs and lines of code.

macc-sg.notion.site/data-catalogue-122e6ba0007d80688d11fa10b6fcbd01

License: none: the authors keep all their rights
State: the link answers, verified on 2 November 2026
Evidence: the link answers
Software Heritage: not checked
Found in: “Data and code availability”
Not found: README, license file, CITATION.cff, environment file, tests, continuous integration, documentation
Availability: 2 checks, the latest on 2 November 2026: the link answers (HTTP 200)
  • 2 November 2026: the link answers (HTTP 200)
  • 3 October 2026: the link answers (HTTP 200)

thomasyeolab/cbig

License: MIT
State: the link answers, verified on 27 October 2026
Evidence: files inventoried
Commit: 634f676630929a71297852d01dd92a287103e861, 1 October 2026
Languages: MATLAB (2110), Shell (652), Python (589), C (113), C++ (65), C/C++ (62), R (25), Jupyter (5)
Size: 9,316 files, 3,621 scripts
Software Heritage: not archived
Found in: “Data and code availability”
Holds: README, license file, environment (external_packages/python/mapalign-master/requirements.txt, external_packages/python/mapalign-master/setup.py, external_packages/python/yapf-master/setup.cfg, external_packages/python/yapf-master/setup.py), tests, documentation, 2 notebooks
Not found: CITATION.cff, continuous integration
Tools: NumPy (130 files), PyTorch (122 files), FreeSurfer (94 files), SciPy (61 files), FieldTrip (60 files), Statistics and Machine Learning Toolbox (50 files), FSL (44 files), SPM (40 files), GIfTI library for MATLAB (10 files), Image Processing Toolbox (8 files), Connectome Workbench (8 files), scikit-learn (5 files), AFNI (2 files), Matplotlib (2 files), Tools for NIfTI and ANALYZE image (MATLAB) (2 files), ANTs (1 file), NiBabel (1 file), Nilearn (1 file), tedana (1 file)
Availability: 2 checks, the latest on 27 October 2026: the link answers
  • 27 October 2026: the link answers
  • 27 September 2026: the link answers
2,000 files

The paper's code and data availability statement is in the Data section.

Tracing map

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  • 2 repositories of the authors' code, each at its verified commit, with its license and how the link was found in the paper;
  • 1,998 scripts, each with its path and the digest of its content;
  • 2 matches between paragraphs of the paper and lines of the code (method lexical-v1);
  • neither the text of the paper nor the code itself.

Its JSON (tracing-map.json) is deposited on Zenodo with its DOI once the map is validated.

Data

No dataset and no data link were found in the paper.

Data and code availability

The ADNI data are publicly available (https://ida.loni.usc.edu/). The MACC dataset can be obtained via a data transfer agreement (https://macc‐sg.notion.site/Data‐Catalogue‐122e6ba0007d80688d11fa10b6fcbd01). Code for this study can be found here: https://github.com/ThomasYeoLab/CBIG/tree/master/stable_projects/fMRI_dynamics/Zhang2026_EIAD. Co‐authors (Z.W. and F.T.) reviewed the code before merging into the GitHub repository to reduce the chance of coding errors.

Reproduced under the paper's license (CC BY), from the paper cited above.

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Version 1, 3 October 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 16 authors, 7 keywords, 14 MeSH terms, 8 funders, 96 references.

Cite

This paper

Zhang, S., Roemer‐Cassiano, S. N., Chong, J. R., Fang, T., Li, Y., Wang, Z., Zeng, T., Li, X., Deco, G., Venketasubramanian, N., Zhou, J. H., Chen, C. L., Alzheimer's Disease Neuroimaging Initiative, Lai, M. K. P., Franzmeier, N., & Yeo, B. T. T. (2026). Excitation-inhibition imbalance links amyloid pathophysiology to cognition in non-demented individuals. Alzheimer's & dementia : the journal of the Alzheimer's Association, 22(10), e71891. https://doi.org/10.1002/alz.71891

BibTeX

@article{zhang2026excitation,
author = {Zhang, Shaoshi and Roemer‐Cassiano, Sebastian N and Chong, Joyce Ruifen and Fang, Tian and Li, Yan and Wang, Ziwen and Zeng, Tianchu and Li, Xin and Deco, Gustavo and Venketasubramanian, Narayanaswamy and Zhou, Juan Helen and Chen, Christopher Li‐Hsian and {Alzheimer's Disease Neuroimaging Initiative} and Lai, Mitchell K P and Franzmeier, Nicolai and Yeo, B T Thomas},
title = {{Excitation-inhibition imbalance links amyloid pathophysiology to cognition in non-demented individuals}},
journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
year = {2026},
month = oct,
volume = {22},
number = {10},
pages = {e71891},
publisher = {Wiley},
issn = {1552-5260},
doi = {10.1002/alz.71891},
url = {https://doi.org/10.1002/alz.71891},
pmid = {42811946},
pmcid = {PMC13624711}
}

RIS

TY - JOUR
AU - Zhang, Shaoshi
AU - Roemer‐Cassiano, Sebastian N
AU - Chong, Joyce Ruifen
AU - Fang, Tian
AU - Li, Yan
AU - Wang, Ziwen
AU - Zeng, Tianchu
AU - Li, Xin
AU - Deco, Gustavo
AU - Venketasubramanian, Narayanaswamy
AU - Zhou, Juan Helen
AU - Chen, Christopher Li‐Hsian
AU - Alzheimer's Disease Neuroimaging Initiative
AU - Lai, Mitchell K P
AU - Franzmeier, Nicolai
AU - Yeo, B T Thomas
TI - Excitation-inhibition imbalance links amyloid pathophysiology to cognition in non-demented individuals
T2 - Alzheimer's & dementia : the journal of the Alzheimer's Association
J2 - Alzheimers Dement
PY - 2026
DA - 2026/10/01
VL - 22
IS - 10
SP - e71891
SN - 1552-5260
PB - Wiley
DO - 10.1002/alz.71891
UR - https://doi.org/10.1002/alz.71891
LA - en
ER -

CSL-JSON

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"title": "Excitation-inhibition imbalance links amyloid pathophysiology to cognition in non-demented individuals",
"container-title": "Alzheimer's & dementia : the journal of the Alzheimer's Association",
"author": [
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"family": "Zhang",
"given": "Shaoshi"
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"family": "Roemer‐Cassiano",
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{
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{
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{
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{
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"given": "Tianchu"
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{
"family": "Li",
"given": "Xin"
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{
"family": "Deco",
"given": "Gustavo"
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{
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{
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{
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{
"literal": "Alzheimer's Disease Neuroimaging Initiative"
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"container-title-short": "Alzheimers Dement",
"volume": "22",
"issue": "10",
"page": "e71891",
"DOI": "10.1002/alz.71891",
"PMID": "42811946",
"PMCID": "PMC13624711",
"ISSN": "1552-5260",
"publisher": "Wiley",
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