Offset Analgesia and Onset Hyperalgesia: A Comparison Between Women With Non-Suicidal Self-Injury and Healthy Women.
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R · 45 lines · 1.3 KB · no license
oaoh_check_corr.R, no license · at the source
Overview
- Department of Clinical Neuroscience Karolinska Institutet Stockholm Sweden
- Institute for Globally Distributed Open Research and Education (IGDORE) Gothenburg Sweden
- Department of Clinical Neuroscience Centre for Psychiatry Research, Karolinska Institutet Stockholm Sweden
- Stockholm Health Care Services, Region Stockholm Stockholm Sweden
- Department of Surgical Sciences Uppsala University Hospital, Uppsala University Uppsala Sweden
Abstract
Background: Individuals who engage in non‐suicidal self‐injury (NSSI) exhibit reduced pain sensitivity compared to the general population. It has been argued that this hypoalgesic characteristic may be attributable to hyper‐effective pain modulation. However, empirical support for this theory remains inconsistent. The aim of the study was to use a combined offset analgesia (OA) and onset hyperalgesia (OH) protocol to investigate if women with NSSI have a propensity to inhibit nociceptive signals to a higher degree (stronger OA response) and facilitate nociceptive signals to a lesser degree (weaker OH response), compared to a control group.
Methods: Data was collected from 76 women, 18–35 age (37 with NSSI and 39 healthy controls). The OA and OH protocol were combined with functional magnetic resonance imaging (fMRI).
Results: The NSSI group displayed a weaker OH response, compared to the control group. This suggests that women with NSSI do not facilitate nociceptive signals to the same extent as healthy women. However, there were no significant differences between the groups regarding OA. Across all participants, we observed stronger activation in the primary sensory cortex during the OH condition, compared to the control condition.
Conclusions: The results offer partial support for the general hypothesis that women with NSSI demonstrate enhanced pain modulation. The fMRI finding requires replication.
Reproduced under the paper's license (CC BY), from the paper cited above.
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oaoh_descriptive.R — R, 108 lines, not shown here - Scripts/
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Data Availability Statement
Data is available upon reasonable request
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Version 1, 27 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 9 authors, 4 keywords, 12 MeSH terms, 3 funders, 24 references.
Cite
This paper
Fust, J., Kastrati, G., Bjureberg, J., Jayaram‐Lindström, N., Hellner, C., Kosek, E., Fransson, P., Jensen, K. B., & Lalouni, M. (2026). Offset Analgesia and Onset Hyperalgesia: A Comparison Between Women With Non-Suicidal Self-Injury and Healthy Women. Brain and behavior, 16(8), e71659. https://
BibTeX
@article{fust2026offset,
author = {Fust, Jens and Kastrati, Granit and Bjureberg, Johan and Jayaram‐Lindström, Nitya and Hellner, Clara and Kosek, Eva and Fransson, Peter and Jensen, Karin B. and Lalouni, Maria},
title = {{Offset Analgesia and Onset Hyperalgesia: A Comparison Between Women With Non-Suicidal Self-Injury and Healthy Women}},
journal = {Brain and behavior},
year = {2026},
month = aug,
volume = {16},
number = {8},
pages = {e71659},
publisher = {Wiley},
issn = {2162-3279},
doi = {10.1002/
url = {https://
pmid = {42603271},
pmcid = {PMC13477226}
}
RIS
TY - JOUR
AU - Fust, Jens
AU - Kastrati, Granit
AU - Bjureberg, Johan
AU - Jayaram‐Lindström, Nitya
AU - Hellner, Clara
AU - Kosek, Eva
AU - Fransson, Peter
AU - Jensen, Karin B.
AU - Lalouni, Maria
TI - Offset Analgesia and Onset Hyperalgesia: A Comparison Between Women With Non-Suicidal Self-Injury and Healthy Women
T2 - Brain and behavior
J2 - Brain Behav
PY - 2026
DA - 2026/
VL - 16
IS - 8
SP - e71659
SN - 2162-3279
PB - Wiley
DO - 10.1002/
UR - https://
LA - en
ER -
CSL-JSON
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