Frequency-Resolved Cortical Functional Connectivity Across the Adult Lifespan.
Overview
- Department of Neuroscience and Biomedical Engineering Aalto University Espoo Finland
- BioMag Laboratory, HUS Diagnostic Center, Helsinki University Hospital Aalto University and University of Helsinki Helsinki Finland
Abstract
The operation of the human brain relies on functional networks enabled by inter‐areal oscillatory synchronization between neuronal populations. Although disruptions in this functional connectivity are associated with brain disorders, evidence on its healthy age‐dependent variation and behavioral relevance remains limited. Utilizing magnetoencephalography (MEG) recordings from 576 adults aged 18–87 years, we investigated the evolution of resting‐state functional connectivity (rs‐FC) across the healthy adult lifespan. We observed age‐related, frequency‐specific changes in widespread cortical networks. Alpha‐band (8–13 Hz) rs‐FC decreased, while delta (1–4 Hz), theta (4–8 Hz), and gamma‐band (40–90 Hz) rs‐FC increased with age. Beta‐band (13–30 Hz) rs‐FC followed a non‐linear trajectory, peaking in middle age. The global delta, theta, alpha, and beta‐band patterns differed from concurrent changes in oscillatory power, underscoring their dissociable contributions. Notably, reduced beta‐band rs‐FC was associated with increased sensorimotor attenuation, indicating that changes in rs‐FC are behaviorally relevant for sensorimotor function. These findings advance our understanding of healthy brain aging and highlight a link between resting‐state brain activity and sensorimotor integration.
Reproduced under the paper's license (CC BY), from the paper cited above.
Code
No file of the authors' code could be read here: it is described below, and read at its source.
camcan-archive.mrc-cbu.cam.ac.uk/dataaccess
Availability: 1 check, the latest on 30 September 2026: the link answers (HTTP 200)
- 30 September 2026: the link answers (HTTP 200)
The paper's code and data availability statement is in the Data section.
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Data
No dataset and no data link were found in the paper.
Data Availability Statement
The original MEG, MRI, and behavioral data are available upon request from the Cam‐CAN data repository (https://
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
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Version 1, 30 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 4 authors, 8 keywords, 16 MeSH terms, 7 funders, 102 references.
Cite
This paper
Ruuskanen, S., Avendano‐Diaz, J. C., Liljeström, M., & Parkkonen, L. (2026). Frequency-Resolved Cortical Functional Connectivity Across the Adult Lifespan. Human brain mapping, 47(4), e70484. https://
BibTeX
@article{ruuskanen2026fr
author = {Ruuskanen, Santeri and Avendano‐Diaz, Juan Camilo and Liljeström, Mia and Parkkonen, Lauri},
title = {{Frequency-Resolved Cortical Functional Connectivity Across the Adult Lifespan}},
journal = {Human brain mapping},
year = {2026},
month = mar,
volume = {47},
number = {4},
pages = {e70484},
publisher = {Wiley},
issn = {1065-9471},
doi = {10.1002/
url = {https://
pmid = {41755554},
pmcid = {PMC12946715}
}
RIS
TY - JOUR
AU - Ruuskanen, Santeri
AU - Avendano‐Diaz, Juan Camilo
AU - Liljeström, Mia
AU - Parkkonen, Lauri
TI - Frequency-Resolved Cortical Functional Connectivity Across the Adult Lifespan
T2 - Human brain mapping
J2 - Hum Brain Mapp
PY - 2026
DA - 2026/
VL - 47
IS - 4
SP - e70484
SN - 1065-9471
PB - Wiley
DO - 10.1002/
UR - https://
LA - en
ER -
CSL-JSON
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