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Nitric Oxide Donor Alleviates Cardiac Arrest Induced Blood Brain Barrier Injury by Inhibiting HMGB1-ATG5 Mediated Endothelial Autophagy.

Overview

Authors: Pengyu Duan1,2, Yonghong Bi1,2, Weiyu Feng1,2, Zhehao Jin1,2, Yao Meng1,2, Hangbing Li1,2, Xiaoyan Li1,2, Lan Luo1,2, Xiangcheng Zhao1,2, Bing Zhang1,2
ORCID iDs: Bing Zhang
  1. Department of Anesthesiology, Second Affiliated Hospital of Harbin Medical University,246 Xuefu Road, Nangang District, Harbin, 150086 Heilongjiang China
  2. Key Laboratory of Anesthesiology and Intensive Care Research of Heilongjiang Province, Harbin, Heilongjiang China
Institutions: Second Affiliated Hospital of Harbin Medical University (China)
Journal: Cellular and molecular neurobiology, volume 46, issue 1, article 74
Dates: received 28 July 2025; accepted 22 February 2026; published online 6 March 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1007/s10571-026-01706-w · PMID 41792371 · PMCID PMC13018516 · OpenAlex W7134109039
Open access: hybrid, a free copy (OpenAlex)
Status: data only
Categories: mouse (organism), cellular / molecular (subfield)
Methods: Spectral & time-frequency, Statistics, Connectivity, fMRI & imaging
Keywords: Cardiac arrest, Blood brain barrier (BBB), JS-K, HMGB1, ATG5, Autophagy
MeSH: Autophagy*, Autophagy-Related Protein 5*, Blood-Brain Barrier*, Endothelial Cells*, Heart Arrest*, HMGB1 Protein*, Nitric Oxide Donors*, Animals, Male, Mice, Mice, Inbred C57BL (* major topic)
Topic: Advanced Glycation End Products research (Clinical Biochemistry, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: National Natural Science Foundation of China (82072129)
Citations: not cited yet (Europe PMC); 60 references in the paper
Research resources: ZO-1 RRID:AB_10733242, Bioss) and Histone H3 RRID:AB_10857220, LAMP2 RRID:AB_11048043, Proteintech) or anti-ATG5 antibody RRID:AB_2062045, LC3B II/I RRID:AB_2137707, RRID:AB_2156308, RRID:AB_2232989, HMGB1 RRID:AB_2295241, RRID:AB_2722565, a mouse anti-HMGB1 primary antibody RRID:AB_2881888, a mouse anti-ATG5 primary antibody RRID:AB_2882092, rabbit anti-CD31 RRID:AB_2922436, China) and rat anti-occludin RRID:AB_3683657, rat anti-ZO-1 RRID:AB_628459

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Datasets cited

Data availability statement

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  • no repository, dataset or request procedure was recognized in it

Read it in the paper: doi.org/10.1007/s10571-026-01706-w.

Versions

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Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 10 authors, 6 keywords, 11 MeSH terms, 1 funder, 60 references, 14 RRIDs.

Cite

This paper

Duan, P., Bi, Y., Feng, W., Jin, Z., Meng, Y., Li, H., Li, X., Luo, L., Zhao, X., & Zhang, B. (2026). Nitric Oxide Donor Alleviates Cardiac Arrest Induced Blood Brain Barrier Injury by Inhibiting HMGB1-ATG5 Mediated Endothelial Autophagy. Cellular and molecular neurobiology, 46(1), 74. https://doi.org/10.1007/s10571-026-01706-w

BibTeX

@article{duan2026nitric,
author = {Duan, Pengyu and Bi, Yonghong and Feng, Weiyu and Jin, Zhehao and Meng, Yao and Li, Hangbing and Li, Xiaoyan and Luo, Lan and Zhao, Xiangcheng and Zhang, Bing},
title = {{Nitric Oxide Donor Alleviates Cardiac Arrest Induced Blood Brain Barrier Injury by Inhibiting HMGB1-ATG5 Mediated Endothelial Autophagy}},
journal = {Cellular and molecular neurobiology},
year = {2026},
month = mar,
volume = {46},
number = {1},
pages = {74},
publisher = {Springer},
issn = {0272-4340},
doi = {10.1007/s10571-026-01706-w},
url = {https://doi.org/10.1007/s10571-026-01706-w},
pmid = {41792371},
pmcid = {PMC13018516}
}

RIS

TY - JOUR
AU - Duan, Pengyu
AU - Bi, Yonghong
AU - Feng, Weiyu
AU - Jin, Zhehao
AU - Meng, Yao
AU - Li, Hangbing
AU - Li, Xiaoyan
AU - Luo, Lan
AU - Zhao, Xiangcheng
AU - Zhang, Bing
TI - Nitric Oxide Donor Alleviates Cardiac Arrest Induced Blood Brain Barrier Injury by Inhibiting HMGB1-ATG5 Mediated Endothelial Autophagy
T2 - Cellular and molecular neurobiology
J2 - Cell Mol Neurobiol
PY - 2026
DA - 2026/03/06
VL - 46
IS - 1
SP - 74
SN - 0272-4340
PB - Springer
DO - 10.1007/s10571-026-01706-w
UR - https://doi.org/10.1007/s10571-026-01706-w
LA - en
ER -

CSL-JSON

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"author": [
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