OSCR

MELK is Required for G2/M Phase Progression in Cortical Progenitors: Insights from Rare ASD-Associated Variants.

Overview

Authors: Liyang Zhao1, Xianjing Li1, Kang Yang1, Miaomiao Jiang1, Zhonghe Chen1, Yiqian Shao1, Tianlan Lu1, Dai Zhang1,2, Lifang Wang1, Jun Li1
ORCID iDs: Liyang Zhao, Xianjing Li, Kang Yang, Miaomiao Jiang, Zhonghe Chen, Yiqian Shao, Tianlan Lu, Dai Zhang, Lifang Wang, Jun Li
  1. National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), NHC Key Laboratory of Mental Health (Peking University), Peking University Sixth Hospital, Peking University Institute of Mental Health, No. 51 Huayuanbei Road, Haidian District, Beijing, 100191 China
  2. Guangdong Key Laboratory of Mental Health and Cognitive Science, Institute for Brain Research and Rehabilitation (IBRR), South China Normal University, Guangzhou, China
Institutions: Peking University (China); Peking University Sixth Hospital (China); South China Normal University (China)
Journal: Cellular and molecular neurobiology, volume 46, issue 1, article 92
Dates: received 9 September 2025; accepted 1 April 2026; published online 13 April 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1007/s10571-026-01728-4 · PMID 41973119 · PMCID PMC13184066 · OpenAlex W7154129247
Open access: hybrid, a free copy (OpenAlex)
Status: data only
Categories: human (organism), mouse (organism), autism (population)
Methods: Statistics, Smoothing, state filtering, decompositions, Evoked potentials, Connectivity
Keywords: MELK, Cortical development, G2/M phase, Neuronal morphology
MeSH: Cell Division*, Cerebral Cortex*, G2 Phase*, Neural Stem Cells*, Protein Serine-Threonine Kinases*, Animals, Gene Knockdown Techniques, Humans, Mice, Neurodevelopment (* major topic)
Topic: FOXO transcription factor regulation (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: National Natural Science Foundation of China (82501856, 82171537, 82271576); the China Disabled Persons' Federation (CDPF2023KF00001); the China Disabled Persons' Federation (CDPF2023KF00001); Non-profit Central Research Institute Chinese Academy of Medical Sciences (2023-PT320-08); Postdoctoral Fellowship Program of CPSF (GZC20251381)
Citations: not cited yet (Europe PMC); 32 references in the paper
Research resources: Mouse anti-Beta Actin RRID:AB_10700003, Rabbit Tbr2 RRID:AB_2721040, Rabbit Ki67 RRID:AB_2756525, Rabbit anti-Melk RRID:AB_2877762, Mouse Tuj1 RRID:AB_477590

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Datasets cited

Data availability statement

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Read it in the paper: doi.org/10.1007/s10571-026-01728-4.

Versions

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Version 1, 29 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 10 authors, 4 keywords, 10 MeSH terms, 5 funders, 32 references, 5 RRIDs.

Cite

This paper

Zhao, L., Li, X., Yang, K., Jiang, M., Chen, Z., Shao, Y., Lu, T., Zhang, D., Wang, L., & Li, J. (2026). MELK is Required for G2/M Phase Progression in Cortical Progenitors: Insights from Rare ASD-Associated Variants. Cellular and molecular neurobiology, 46(1), 92. https://doi.org/10.1007/s10571-026-01728-4

BibTeX

@article{zhao2026melk,
author = {Zhao, Liyang and Li, Xianjing and Yang, Kang and Jiang, Miaomiao and Chen, Zhonghe and Shao, Yiqian and Lu, Tianlan and Zhang, Dai and Wang, Lifang and Li, Jun},
title = {{MELK is Required for G2/M Phase Progression in Cortical Progenitors: Insights from Rare ASD-Associated Variants}},
journal = {Cellular and molecular neurobiology},
year = {2026},
month = apr,
volume = {46},
number = {1},
pages = {92},
publisher = {Springer},
issn = {0272-4340},
doi = {10.1007/s10571-026-01728-4},
url = {https://doi.org/10.1007/s10571-026-01728-4},
pmid = {41973119},
pmcid = {PMC13184066}
}

RIS

TY - JOUR
AU - Zhao, Liyang
AU - Li, Xianjing
AU - Yang, Kang
AU - Jiang, Miaomiao
AU - Chen, Zhonghe
AU - Shao, Yiqian
AU - Lu, Tianlan
AU - Zhang, Dai
AU - Wang, Lifang
AU - Li, Jun
TI - MELK is Required for G2/M Phase Progression in Cortical Progenitors: Insights from Rare ASD-Associated Variants
T2 - Cellular and molecular neurobiology
J2 - Cell Mol Neurobiol
PY - 2026
DA - 2026/04/13
VL - 46
IS - 1
SP - 92
SN - 0272-4340
PB - Springer
DO - 10.1007/s10571-026-01728-4
UR - https://doi.org/10.1007/s10571-026-01728-4
LA - en
ER -

CSL-JSON

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"container-title": "Cellular and molecular neurobiology",
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