OSCR

IRF7 Modulates Inflammatory Pain Through Upregulating IFNβ in Mice Trigeminal Ganglion.

Overview

Authors: Lijia Mai1,2,3, Xiaoxia Ma2,3, Hui Yang2,3, Shilin Jia2,3, Yifan He1,2,3, Hongwen He2,3, Wenguo Fan1,2,3, Fang Huang1,2,3
  1. Hospital of Stomatology, Sun Yat-sen University, Guangzhou, 510055 China
  2. Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, 510055 China
  3. Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, 510055 China
Institutions: Sun Yat-sen University (China); Hospital of Stomatology, Sun Yat-sen University
Journal: Inflammation, volume 49, issue 1, article 106
Dates: received 23 November 2025; accepted 19 February 2026; published online 1 March 2026; in print 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1007/s10753-026-02483-w · PMID 41764111 · PMCID PMC13002720 · OpenAlex W7132834548
Open access: hybrid, a free copy (OpenAlex)
Status: data only
Categories: mouse (organism), pain (population), cellular / molecular (subfield)
Methods: Statistics, Evoked potentials, fMRI & imaging
Keywords: Orofacial pain, Interferon regulatory factor 7, Interferon Beta, Trigeminal ganglion, Neuroinflammation
MeSH: Facial Pain*, Inflammation*, Interferon Regulatory Factor-7*, Interferon-beta*, Trigeminal Ganglion*, Animals, Hyperalgesia, Male, Mice, Mice, Inbred C57BL, Up-Regulation (* major topic)
Topic: Pain Mechanisms and Treatments (Physiology, Medicine), according to OpenAlex
Funding: Guangzhou Municipal Science and Technology Project (2024A04J4856); National Natural Science Foundation of China (82270997)
Citations: not cited yet (Europe PMC); 41 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

The paper links to its data, not to its authors' code: see the Data section.

Tracing map

A tracing map links a paper to the code its authors published: this paper has none, so it has no map.

Data

Datasets cited

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • no repository, dataset or request procedure was recognized in it

Read it in the paper: doi.org/10.1007/s10753-026-02483-w.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 8 authors, 5 keywords, 11 MeSH terms, 2 funders, 40 references.

Cite

This paper

Mai, L., Ma, X., Yang, H., Jia, S., He, Y., He, H., Fan, W., & Huang, F. (2026). IRF7 Modulates Inflammatory Pain Through Upregulating IFNβ in Mice Trigeminal Ganglion. Inflammation, 49(1), 106. https://doi.org/10.1007/s10753-026-02483-w

BibTeX

@article{mai2026irf7,
author = {Mai, Lijia and Ma, Xiaoxia and Yang, Hui and Jia, Shilin and He, Yifan and He, Hongwen and Fan, Wenguo and Huang, Fang},
title = {{IRF7 Modulates Inflammatory Pain Through Upregulating IFNβ in Mice Trigeminal Ganglion}},
journal = {Inflammation},
year = {2026},
month = mar,
volume = {49},
number = {1},
pages = {106},
publisher = {Springer Science+Business Media},
issn = {0360-3997},
doi = {10.1007/s10753-026-02483-w},
url = {https://doi.org/10.1007/s10753-026-02483-w},
pmid = {41764111},
pmcid = {PMC13002720}
}

RIS

TY - JOUR
AU - Mai, Lijia
AU - Ma, Xiaoxia
AU - Yang, Hui
AU - Jia, Shilin
AU - He, Yifan
AU - He, Hongwen
AU - Fan, Wenguo
AU - Huang, Fang
TI - IRF7 Modulates Inflammatory Pain Through Upregulating IFNβ in Mice Trigeminal Ganglion
T2 - Inflammation
J2 - Inflammation
PY - 2026
DA - 2026/03/01
VL - 49
IS - 1
SP - 106
SN - 0360-3997
PB - Springer Science+Business Media
DO - 10.1007/s10753-026-02483-w
UR - https://doi.org/10.1007/s10753-026-02483-w
LA - en
ER -

CSL-JSON

{
"id": "10.1007/s10753-026-02483-w",
"type": "article-journal",
"title": "IRF7 Modulates Inflammatory Pain Through Upregulating IFNβ in Mice Trigeminal Ganglion",
"container-title": "Inflammation",
"author": [
{
"family": "Mai",
"given": "Lijia"
},
{
"family": "Ma",
"given": "Xiaoxia"
},
{
"family": "Yang",
"given": "Hui"
},
{
"family": "Jia",
"given": "Shilin"
},
{
"family": "He",
"given": "Yifan"
},
{
"family": "He",
"given": "Hongwen"
},
{
"family": "Fan",
"given": "Wenguo"
},
{
"family": "Huang",
"given": "Fang"
}
],
"container-title-short": "Inflammation",
"volume": "49",
"issue": "1",
"page": "106",
"DOI": "10.1007/s10753-026-02483-w",
"PMID": "41764111",
"PMCID": "PMC13002720",
"ISSN": "0360-3997",
"publisher": "Springer Science+Business Media",
"URL": "https://doi.org/10.1007/s10753-026-02483-w",
"language": "en",
"issued": {
"date-parts": [
[
2026,
3,
1
]
]
}
}

Similar papers

The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.

[1] doi:10.1038/s41593-026-02234-y [code]
Persistent interferon signaling causes sensory neuron plasticity and pain before and during arthritis.
Journal: Nature neuroscience
In common: pain, mouse, cellular / molecular, 5 references
[2] doi:10.1007/s10565-026-10177-0
Multi-omics analysis and experimental validation reveal the IRF7-CXCL10 axis as a master regulator of microglial PCD in ischemic stroke.
Journal: Cell biology and toxicology
In common: mouse, cellular / molecular, 3 references
[3] doi:10.1002/advs.77364
ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4-based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons.
Journal: Advanced science (Weinheim, Baden-Wurttemberg, Germany)
In common: pain, cellular / molecular, 2 references
[4] doi:10.7554/elife.100451
Translational control in the spinal cord regulates gene expression and pain hypersensitivity in the chronic phase of neuropathic pain.
Journal: eLife
In common: pain, mouse, cellular / molecular, 1 reference
[5] doi:10.1016/j.isci.2026.116634
Keratinocytes and PDGF-B/PDGFRβ signaling modulate peripheral opioid tolerance.
Journal: iScience
In common: pain, cellular / molecular, 1 reference
[6] doi:10.1186/s12929-026-01256-9
Microglial MARCO facilitates Varicella zoster virus uptake and triggers TLR2-mediated neuroinflammation.
Journal: Journal of biomedical science
In common: pain, cellular / molecular, 1 reference
[7] doi:10.1038/s41586-026-10296-y [code]
Deconstruction of a spino-brain-spinal cord circuit that drives chronic pain.
Journal: Nature
In common: pain, mouse, 1 reference
[8] doi:10.1038/s41467-026-73543-w
Engineering technology of implantable galvanic cells for silencing the bone-neural axis in gouty arthritis therapy.
Journal: Nature communications
In common: pain, 1 reference
[9] doi:10.1016/j.celrep.2026.117418 [code]
Astrocyte-microglia crosstalk via CSF1 and IFN-β promotes central nervous system repair.
Journal: Cell reports
In common: mouse, cellular / molecular, 1 reference
[10] doi:10.1002/advs.75389
Boosting Sensory Nerve-to-Bone Interactions Enhances Hedgehog Mediated Calvarial Bone Repair.
Journal: Advanced science (Weinheim, Baden-Wurttemberg, Germany)
In common: mouse, cellular / molecular, 1 reference

Contribute

The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.

Sign in with ORCID to claim this paper as one of its authors, correct its record or validate its tracing map: when the paper's metadata lists your ORCID iD, you are recognized at once. Maintainers of its code: sign in with GitHub, then claim the repository on your account page.

Request its removal

To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).

Discussion, reproductions, activity

Discussion: questions and error reports about this paper and its code, from signed-in readers and its authors. It opens with sign-in.

Reproductions: reports from readers who ran the authors' code: what they reproduced, with which environment, commit and data. It opens with sign-in.

Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.