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The mediating effect of neuroticism on the association between brain signal variability in the prefrontal cortex and depression among healthy individuals.

Overview

Authors: Fengmei Lu1, Yajing Pang2, Ting Li1, Mengfan Liu1, Chen Jia1, Jingjing Gao3, Wei Luo1, Yue Yu1, Lu Wang1, Qin Tang1, Qian Cui4, Qing Gao5,6, Zongling He1, Huafu Chen1,7
  1. The Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 611731 PR China
  2. Henan Key Laboratory of Brain Science and Brain-Computer Interface Technology, School of Electrical and Information Engineering, Zhengzhou University, Zhengzhou, 450001 China
  3. School of Information and Communication Engineering, University of Electronic Science and Technology of China, Chengdu, 611731 China
  4. School of Public Affairs and Administration, University of Electronic Science and Technology of China, Chengdu, 611731 PR China
  5. School of Mathematical Sciences, University of Electronic Science and Technology of China, Chengdu, 611731 PR China
  6. Kash Institute of Electronics and Information Industry, Kashi, 844099 P.R. China
  7. MOE Key Lab for Neuroinformation, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, University of Electronic Science and Technology of China, Chengdu, 611731 PR China
Institutions: University of Electronic Science and Technology of China (China); Zhengzhou University (China)
Journal: Brain imaging and behavior, volume 20, issue 5, article 132
Dates: received 22 January 2025; accepted 17 August 2026; published online 29 September 2026; in print 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1007/s11682-026-01194-y · PMID 42806157 · PMCID PMC13619728 · OpenAlex W7214667602
Open access: hybrid, a free copy (OpenAlex)
Status: code on request (how the code is found and verified)
Categories: human (organism), depression (population), systems (subfield)
Methods: Spectral & time-frequency, Connectivity, Preprocessing, Statistics, fMRI & imaging
Keywords: Neuroticism, Brain signal variability, Prefrontal cortex, Depressive symptoms, Mediation
MeSH: Depression*, Neuroticism*, Prefrontal Cortex*, Adult, Brain, Brain Mapping, Female, Humans, Magnetic Resonance Imaging, Male, Young Adult (* major topic)
Topic: Neural and Behavioral Psychology Studies (Cognitive Neuroscience, Neuroscience), according to OpenAlex
Funding: the Autonomous Region Science and Technology Plan Project (2024D01A15); Medical Research Project of Chengdu (2024053, 2024150); the National Natural Science Foundation of China (62276049, 61701078, 62333003, 82121003, 62036003, 82172059, 62173069, 62173070); The Natural Science Foundation of Sichuan Province (2025ZNSFSC0487); the Natural Science Foundation of China (62103377); the General Program of Natural Science Foundation of Sichuan Province (2026NSFSC0468); Medico-Engineering Cooperation Funds from University of Electronic Science and Technology of China (ZYGX2021YGLH201); Science and Technology Bureau of Chengdu Program (2024-YF05-00873-SN); the National Key R&D Program of China (2024YFE0215100); the Key Technologies Research and Development Program of Henan Province (252102311096)
Citations: not cited yet (Europe PMC); 86 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Code availability statement

The paper has a code availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • it says that the code is available on request

Read it in the paper: doi.org/10.1007/s11682-026-01194-y.

Tracing map

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Data

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Data availability statement

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  • it says that the data are available on request

Read it in the paper: doi.org/10.1007/s11682-026-01194-y.

Versions

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Version 1, 1 October 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 14 authors, 5 keywords, 11 MeSH terms, 10 funders, 78 references.

Cite

This paper

Lu, F., Pang, Y., Li, T., Liu, M., Jia, C., Gao, J., Luo, W., Yu, Y., Wang, L., Tang, Q., Cui, Q., Gao, Q., He, Z., & Chen, H. (2026). The mediating effect of neuroticism on the association between brain signal variability in the prefrontal cortex and depression among healthy individuals. Brain imaging and behavior, 20(5), 132. https://doi.org/10.1007/s11682-026-01194-y

BibTeX

@article{lu2026mediating,
author = {Lu, Fengmei and Pang, Yajing and Li, Ting and Liu, Mengfan and Jia, Chen and Gao, Jingjing and Luo, Wei and Yu, Yue and Wang, Lu and Tang, Qin and Cui, Qian and Gao, Qing and He, Zongling and Chen, Huafu},
title = {{The mediating effect of neuroticism on the association between brain signal variability in the prefrontal cortex and depression among healthy individuals}},
journal = {Brain imaging and behavior},
year = {2026},
month = sep,
volume = {20},
number = {5},
pages = {132},
publisher = {Springer Science+Business Media},
issn = {1931-7557},
doi = {10.1007/s11682-026-01194-y},
url = {https://doi.org/10.1007/s11682-026-01194-y},
pmid = {42806157},
pmcid = {PMC13619728}
}

RIS

TY - JOUR
AU - Lu, Fengmei
AU - Pang, Yajing
AU - Li, Ting
AU - Liu, Mengfan
AU - Jia, Chen
AU - Gao, Jingjing
AU - Luo, Wei
AU - Yu, Yue
AU - Wang, Lu
AU - Tang, Qin
AU - Cui, Qian
AU - Gao, Qing
AU - He, Zongling
AU - Chen, Huafu
TI - The mediating effect of neuroticism on the association between brain signal variability in the prefrontal cortex and depression among healthy individuals
T2 - Brain imaging and behavior
J2 - Brain Imaging Behav
PY - 2026
DA - 2026/09/29
VL - 20
IS - 5
SP - 132
SN - 1931-7557
PB - Springer Science+Business Media
DO - 10.1007/s11682-026-01194-y
UR - https://doi.org/10.1007/s11682-026-01194-y
LA - en
ER -

CSL-JSON

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