OSCR

A Lipoylation-PDH-TCA Transcriptional Deficit in the Alzheimer's Disease Cortex - Donor-level Multi-cohort Evidence with Neuronal-composition, Disease-specificity and Matched-null Controls.

Overview

Authors: Tao Zhang1, Xiaodong Chen1, Yi Wang2, Yu Wang3
ORCID iDs: Tao Zhang, Yu Wang
  1. The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054 Xinjiang Uygur Autonomous Region China
  2. Xinjiang Medical University, Urumqi, 830011 Xinjiang Uygur Autonomous Region China
  3. Health Management Research Institute and College of Health Management, Xinjiang Medical University, No. 393 Xinyi Road, Urumqi, 830011 Xinjiang Uygur Autonomous Region China
Institutions: First Affiliated Hospital of Xinjiang Medical University (China); Xinjiang Medical University (China)
Journal: Journal of molecular neuroscience : MN, volume 76, issue 4, article 143
Dates: received 19 July 2026; accepted 3 September 2026; published online 17 September 2026; in print 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1007/s12031-026-02598-7 · PMID 42752765 · PMCID PMC13585864 · OpenAlex W7213465181
Open access: hybrid, a free copy (OpenAlex)
Status: data only (how the code is found and verified)
Categories: genetics / omics (modality), human (organism), Alzheimer's / dementia (population)
Methods: Statistics, Smoothing, state filtering, decompositions, Machine learning, Connectivity
Keywords: Alzheimer’s disease, PDHA1, Pyruvate dehydrogenase, Lipoylation, Donor-level analysis, Transcriptomic meta-analysis
MeSH: Alzheimer Disease*, Citric Acid Cycle*, Neurons*, Prefrontal Cortex*, Cuproptosis, Humans, Lipoylation, Male (* major topic)
Topic: Alzheimer's disease research and treatments (Cellular and Molecular Neuroscience, Neuroscience), according to OpenAlex
Funding: Natural Science Foundation of Xinjiang
Citations: not cited yet (Europe PMC); 58 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

The paper links to its data and to no code of its authors: see the Data section.

The paper's code and data availability statement is in the Data section.

Tracing map

A tracing map links a paper to the code its authors published: this paper has none, so it has no map.

Data

Datasets cited

Code and data availability statement

The paper has a code and data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • no repository, dataset or request procedure was recognized in it

Read it in the paper: doi.org/10.1007/s12031-026-02598-7.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 3, 28 September 2026

  • Publisher: n/a → Springer Science+Business Media
  • Funding: added Natural Science Foundation of Xinjiang

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 4 authors, 6 keywords, 8 MeSH terms, 58 references.

Cite

This paper

Zhang, T., Chen, X., Wang, Y., & Wang, Y. (2026). A Lipoylation-PDH-TCA Transcriptional Deficit in the Alzheimer's Disease Cortex - Donor-level Multi-cohort Evidence with Neuronal-composition, Disease-specificity and Matched-null Controls. Journal of molecular neuroscience : MN, 76(4), 143. https://doi.org/10.1007/s12031-026-02598-7

BibTeX

@article{zhang2026lipoylation,
author = {Zhang, Tao and Chen, Xiaodong and Wang, Yi and Wang, Yu},
title = {{A Lipoylation-PDH-TCA Transcriptional Deficit in the Alzheimer's Disease Cortex - Donor-level Multi-cohort Evidence with Neuronal-composition, Disease-specificity and Matched-null Controls}},
journal = {Journal of molecular neuroscience : MN},
year = {2026},
month = sep,
volume = {76},
number = {4},
pages = {143},
publisher = {Springer Science+Business Media},
issn = {0895-8696},
doi = {10.1007/s12031-026-02598-7},
url = {https://doi.org/10.1007/s12031-026-02598-7},
pmid = {42752765},
pmcid = {PMC13585864}
}

RIS

TY - JOUR
AU - Zhang, Tao
AU - Chen, Xiaodong
AU - Wang, Yi
AU - Wang, Yu
TI - A Lipoylation-PDH-TCA Transcriptional Deficit in the Alzheimer's Disease Cortex - Donor-level Multi-cohort Evidence with Neuronal-composition, Disease-specificity and Matched-null Controls
T2 - Journal of molecular neuroscience : MN
J2 - J Mol Neurosci
PY - 2026
DA - 2026/09/17
VL - 76
IS - 4
SP - 143
SN - 0895-8696
PB - Springer Science+Business Media
DO - 10.1007/s12031-026-02598-7
UR - https://doi.org/10.1007/s12031-026-02598-7
LA - en
ER -

CSL-JSON

{
"id": "10.1007/s12031-026-02598-7",
"type": "article-journal",
"title": "A Lipoylation-PDH-TCA Transcriptional Deficit in the Alzheimer's Disease Cortex - Donor-level Multi-cohort Evidence with Neuronal-composition, Disease-specificity and Matched-null Controls",
"container-title": "Journal of molecular neuroscience : MN",
"author": [
{
"family": "Zhang",
"given": "Tao"
},
{
"family": "Chen",
"given": "Xiaodong"
},
{
"family": "Wang",
"given": "Yi"
},
{
"family": "Wang",
"given": "Yu"
}
],
"container-title-short": "J Mol Neurosci",
"volume": "76",
"issue": "4",
"page": "143",
"DOI": "10.1007/s12031-026-02598-7",
"PMID": "42752765",
"PMCID": "PMC13585864",
"ISSN": "0895-8696",
"publisher": "Springer Science+Business Media",
"URL": "https://doi.org/10.1007/s12031-026-02598-7",
"language": "en",
"issued": {
"date-parts": [
[
2026,
9,
17
]
]
}
}

Similar papers

The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.

[1] doi:10.1002/trc2.12373
Altered gene expression in excitatory neurons is associated with Alzheimer's disease and its higher incidence in women.
Journal: Alzheimer's & dementia (New York, N. Y.)
In common: NCBI GEO GSE157827, Alzheimer's / dementia, genetics / omics, 5 references
[2] doi:10.1002/alz.14187 [code]
Cognitive resilience to Alzheimer's disease characterized by cell-type abundance.
Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association
In common: NCBI GEO GSE157827, Alzheimer's / dementia, genetics / omics, 4 references
[3] doi:10.1093/bib/bbag411 [code]
Screening of cell-type-specific meta-programs for drug repurposing in Alzheimer's disease.
Journal: Briefings in bioinformatics
In common: Alzheimer's / dementia, genetics / omics, 8 references
[4] doi:10.1038/s41467-026-77651-5 [code]
Single-cell machine learning uncovers genetically anchored, cell-type specific programs of Alzheimer's disease.
Journal: Nature communications
In common: NCBI GEO GSE157827, Alzheimer's / dementia, genetics / omics, 3 references
[5] doi:10.34133/csbj.0085 [code]
A Systems-Level Transcriptomic Framework Identifies Shared Cellular Hubs in Osteoarthritis and Alzheimer's Disease.
Journal: Computational and structural biotechnology journal
In common: Alzheimer's / dementia, genetics / omics, 8 references
[6] doi:10.1038/s42003-025-08674-9 [code]
Association of genetic scores related to insulin resistance with neurological outcomes in ancestrally diverse cohorts from the Trans-Omics for Precision Medicine (TOPMed) program.
Journal: Communications biology
In common: 5 references
[7] doi:10.1038/s41467-023-40503-7 [code]
Cell-type-specific co-expression inference from single cell RNA-sequencing data.
Journal: Nature communications
In common: NCBI GEO GSE157827, genetics / omics, 3 references
[8] doi:10.3390/brainsci15020205
The Endothelial Cell-Related Genes <i>EIF1</i> and <i>HSPA1B</i> Contribute to the Pathogenesis of Alzheimer's Disease by Modulating Peripheral Immunoinflammatory Responses.
Journal: Brain sciences
In common: NCBI GEO GSE157827, Alzheimer's / dementia, genetics / omics, 2 references
[9] doi:10.1007/s10571-025-01536-2 [code]
Single-Cell Analysis of Sex and Gender Differences in the Human Brain During Development and Disease.
Journal: Cellular and molecular neurobiology
In common: NCBI GEO GSE157827, Alzheimer's / dementia, genetics / omics, 2 references
[10] doi:10.1186/s13195-026-02081-w [code]
Cellular state heterogeneity underlying sex differences in Alzheimer's disease based on single-cell transcriptome.
Journal: Alzheimer's research & therapy
In common: Alzheimer's / dementia, genetics / omics, 6 references

Contribute

The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.

Sign in with ORCID to claim this paper as one of its authors, correct its record or validate its tracing map: when the paper's metadata lists your ORCID iD, you are recognized at once. Maintainers of its code: sign in with GitHub, then claim the repository on your account page.

Request its removal

To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).

Discussion, reproductions, activity

Discussion: code errors and mismatches between the code and the paper about this paper and its code, from readers and its authors, beside the paper and its tracing map.

Reproductions: reports from readers who ran the authors' code and did not get the paper's result, what they ran, with which environment, commit and data.

Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.