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A Lipoylation-PDH-TCA Transcriptional Deficit in the Alzheimer's Disease Cortex - Donor-level Multi-cohort Evidence with Neuronal-composition, Disease-specificity and Matched-null Controls.

Overview

Authors: Tao Zhang1, Xiaodong Chen1, Yi Wang2, Yu Wang3
ORCID iDs: Tao Zhang, Yu Wang
  1. The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054 Xinjiang Uygur Autonomous Region China
  2. Xinjiang Medical University, Urumqi, 830011 Xinjiang Uygur Autonomous Region China
  3. Health Management Research Institute and College of Health Management, Xinjiang Medical University, No. 393 Xinyi Road, Urumqi, 830011 Xinjiang Uygur Autonomous Region China
Institutions: First Affiliated Hospital of Xinjiang Medical University (China); Xinjiang Medical University (China)
Journal: Journal of molecular neuroscience : MN, volume 76, issue 4, article 143
Dates: received 19 July 2026; accepted 3 September 2026; published online 17 September 2026; in print 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1007/s12031-026-02598-7 · PMID 42752765 · PMCID PMC13585864 · OpenAlex W7213465181
Open access: hybrid, a free copy (OpenAlex)
Status: data only
Categories: genetics / omics (modality), human (organism), Alzheimer's / dementia (population)
Methods: Statistics, Smoothing, state filtering, decompositions, Machine learning, Connectivity
Keywords: Alzheimer’s disease, PDHA1, Pyruvate dehydrogenase, Lipoylation, Donor-level analysis, Transcriptomic meta-analysis
MeSH: Alzheimer Disease*, Citric Acid Cycle*, Neurons*, Prefrontal Cortex*, Cuproptosis, Humans, Lipoylation, Male (* major topic)
Topic: Alzheimer's disease research and treatments (Physiology, Medicine), according to OpenAlex
Funding: Natural Science Foundation of Xinjiang
Citations: not cited yet (Europe PMC); 58 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Datasets cited

Code and data availability statement

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Read it in the paper: doi.org/10.1007/s12031-026-02598-7.

Versions

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Version 3, 28 September 2026

  • Publisher: — → Springer Science+Business Media
  • Funding: added Natural Science Foundation of Xinjiang

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 4 authors, 6 keywords, 8 MeSH terms, 58 references.

Cite

This paper

Zhang, T., Chen, X., Wang, Y., & Wang, Y. (2026). A Lipoylation-PDH-TCA Transcriptional Deficit in the Alzheimer's Disease Cortex - Donor-level Multi-cohort Evidence with Neuronal-composition, Disease-specificity and Matched-null Controls. Journal of molecular neuroscience : MN, 76(4), 143. https://doi.org/10.1007/s12031-026-02598-7

BibTeX

@article{zhang2026lipoylation,
author = {Zhang, Tao and Chen, Xiaodong and Wang, Yi and Wang, Yu},
title = {{A Lipoylation-PDH-TCA Transcriptional Deficit in the Alzheimer's Disease Cortex - Donor-level Multi-cohort Evidence with Neuronal-composition, Disease-specificity and Matched-null Controls}},
journal = {Journal of molecular neuroscience : MN},
year = {2026},
month = sep,
volume = {76},
number = {4},
pages = {143},
publisher = {Springer Science+Business Media},
issn = {0895-8696},
doi = {10.1007/s12031-026-02598-7},
url = {https://doi.org/10.1007/s12031-026-02598-7},
pmid = {42752765},
pmcid = {PMC13585864}
}

RIS

TY - JOUR
AU - Zhang, Tao
AU - Chen, Xiaodong
AU - Wang, Yi
AU - Wang, Yu
TI - A Lipoylation-PDH-TCA Transcriptional Deficit in the Alzheimer's Disease Cortex - Donor-level Multi-cohort Evidence with Neuronal-composition, Disease-specificity and Matched-null Controls
T2 - Journal of molecular neuroscience : MN
J2 - J Mol Neurosci
PY - 2026
DA - 2026/09/17
VL - 76
IS - 4
SP - 143
SN - 0895-8696
PB - Springer Science+Business Media
DO - 10.1007/s12031-026-02598-7
UR - https://doi.org/10.1007/s12031-026-02598-7
LA - en
ER -

CSL-JSON

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"container-title": "Journal of molecular neuroscience : MN",
"author": [
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"PMID": "42752765",
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"ISSN": "0895-8696",
"publisher": "Springer Science+Business Media",
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"language": "en",
"issued": {
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