Brain dynamics of attentional, default-mode and limbic networks are disrupted at rest in post-COVID-19 syndrome.
The 4 matches
- [1] § Neuroimaging data acquisition and processing › LEiDA analyses ↔ LEiDA/LEiDA.m, lines 38–112 · score 0.78 · bandpass filtered, Hilbert transform, phase synchrony, BOLD signal, leading eigenvector, V1
- [2] § Neuroimaging data acquisition and processing › LEiDA analyses ↔ MUSIC_preadolescents/LEiDA_v6.m, lines 39–115 · score 0.78 · bandpass filtered, Hilbert transform, phase synchrony, BOLD signal, leading eigenvector, V1
- [3] § Neuroimaging data acquisition and processing › LEiDA analyses ↔ LEiDA/LEiDA.m, lines 38–112 · score 0.70 · Hilbert transformed, phase synchrony, leading eigenvector, V1, parcellation, instantaneous
- [4] § Neuroimaging data acquisition and processing › LEiDA analyses ↔ MUSIC_preadolescents/LEiDA_v6.m, lines 39–115 · score 0.70 · Hilbert transformed, phase synchrony, leading eigenvector, V1, parcellation, instantaneous
Paper
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The authors' code
MATLAB · 299 lines · 11 KB · no license · 2 matches
- function LEiDA(varargin)
- %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
- %
- % LEADING EIGENVECTOR DYNAMICS ANALYSIS (LEiDA)
- %
- % This function processes, clusters and analyses BOLD data using LEiDA.
- % Here the example_BOLD is a dataset containing rest and task conditions
- %
- % NOTE: Step 4 can be run independently once data is saved by calling
- % LEiDA('LEiDA_results.mat')
- %
- % 1 - Read the BOLD data from the folders and computes the BOLD phases
- % - Calculate the instantaneous BOLD synchronization matrix
- % - Compute the Leading Eigenvector at each frame from all fMRI scans
- % 2 - Cluster the Leading Eigenvectors
- % 3 - Compute the probability and lifetimes each cluster in each session
- % - Calculate signigifance between tasks
- % - Saves the Eigenvectors, Clusters and statistics into LEiDA_results.mat
- %
- % 4 - Plots FC states and errorbars for each clustering solution
- % - Adds an asterisk when results are significantly different between
- % tasks
- %
- %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
- % Joana Cabral Oct 2017
- % [email hidden]
- %
- % First use in
- % Cabral, et al. 2017 Scientific reports 7, no. 1 (2017): 5135.
- %
- %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
- if isempty(varargin) % If no input is given, compute LEiDA
- %% 1 - Compute the Leading Eigenvectors from the BOLD datasets
- disp('Processing the eigenvectors from BOLD data')
- % Load here the BOLD data (which may be in different formats)
- % Here the BOLD time courses in AAL parcellation are organized as cells,
- % where tc_aal{1,1} corresponds to the BOLD data from subject 1 in
- % condition 1 and contains a matrix with lines=N_areas and columns=Tmax.
- load example_BOLD.mat tc_aal
- [n_Subjects, n_Task]=size(tc_aal);
- [N_areas, Tmax]=size(tc_aal{1,1});
- % Parameters of the data
- TR=2; % Repetition Time (seconds)
- % Preallocate variables to save FC patterns and associated information
- Leading_Eig=zeros(Tmax*n_Subjects,N_areas); % All leading eigenvectors
- Time_all=zeros(2, n_Subjects*Tmax); % vector with subject nr and task at each t
- t_all=0; % Index of time (starts at 0 and will be updated until n_Sub*Tmax)
- % Bandpass filter settings
- fnq=1/(2*TR); % Nyquist frequency
- flp = .02; % lowpass frequency of filter (Hz)
- fhi = 0.1; % highpass
- Wn=[flp/fnq fhi/fnq]; % butterworth bandpass non-dimensional frequency
- k=2; % 2nd order butterworth filter
- [bfilt,afilt]=butter(k,Wn); % construct the filter
- clear fnq flp fhi Wn k
- for s=1:n_Subjects
- for task=1:n_Task
- % Get the BOLD signals from this subject in this task
- BOLD = tc_aal{s,task};
- % [Tmax]=size(BOLD,2); Get Tmax here, if it changes between scans
- Phase_BOLD=zeros(N_areas,Tmax);
- % Get the BOLD phase using the Hilbert transform
- for seed=1:N_areas
- BOLD(seed,:)=BOLD(seed,:)-mean(BOLD(seed,:));
- signal_filt =filtfilt(bfilt,afilt,BOLD(seed,:));
- Phase_BOLD(seed,:) = angle(hilbert(signal_filt));
- end
- for t=1:Tmax
- %Calculate the Instantaneous FC (BOLD Phase Synchrony)
- iFC=zeros(N_areas);
- for n=1:N_areas
- for p=1:N_areas
- iFC(n,p)=cos(Phase_BOLD(n,t)-Phase_BOLD(p,t));
- end
- end
- % Get the leading eigenvector
- [V1,~]=eigs(iFC,1);
- % Make sure the largest component is negative
- % This step is important because the same eigenvector can
- % be returned either as V or its symmetric -V and we need
- % to make sure it is always the same (so we choose always
- % the most negative one)
- if mean(V1>0)>.5
- V1=-V1;
- elseif mean(V1>0)==.5 && sum(V1(V1>0))>-sum(V1(V1<0))
- V1=-V1;
- end
- % Save V1 from all frames in all fMRI sessions in Leading eig
- t_all=t_all+1; % Update time
- Leading_Eig(t_all,:)=V1;
- Time_all(:,t_all)=[s task]; % Information that at t_all, V1 corresponds to subject s in a given task
- end
- end
- end
- clear BOLD tc_aal signal_filt iFC V1 Phase_BOLD
- %% 2 - Cluster the Leading Eigenvectors
- disp('Clustering the eigenvectors into')
- % Leading_Eig is a matrix containing all the eigenvectors:
- % Collumns: N_areas are brain areas (variables)
- % Rows: Tmax*n_Subjects are all time points (independent observations)
- % Set maximum/minimum number of clusters
- % There is no fixed number of states the brain can display
- % Extend the range depending on the hypothesis of each work
- maxk=12;
- mink=3;
- rangeK=mink:maxk;
- % Set the parameters for Kmeans clustering
- Kmeans_results=cell(size(rangeK));
- for k=1:length(rangeK)
- disp(['- ' num2str(rangeK(k)) ' clusters'])
- [IDX, C, SUMD, D]=kmeans(Leading_Eig,rangeK(k),'Replicates',10,'MaxIter',1000,'Display','off','Options',statset('UseParallel',1));
- Kmeans_results{k}.IDX=IDX; % Cluster time course - numeric collumn vectos
- Kmeans_results{k}.C=C; % Cluster centroids (FC patterns)
- Kmeans_results{k}.SUMD=SUMD; % Within-cluster sums of point-to-centroid distances
- Kmeans_results{k}.D=D; % Distance from each point to every centroid
- end
- save LEiDA_results.mat Leading_Eig Time_all Kmeans_results
- %% 3 - Analyse the Clustering results
- % For every fMRI scan calculate probability and lifetimes of each pattern c.
- P=zeros(n_Task,n_Subjects,maxk-mink+1,maxk);
- LT=zeros(n_Task,n_Subjects,maxk-mink+1,maxk);
- for k=1:length(rangeK)
- for task=1:n_Task % 1, Baselineline, 2, baby face task
- for s=1:n_Subjects
- % Select the time points representing this subject and task
- T=((Time_all(1,:)==s)+(Time_all(2,:)==task))>1;
- Ctime=Kmeans_results{k}.IDX(T);
- for c=1:rangeK(k)
- % Probability
- P(task,s,k,c)=mean(Ctime==c);
- % Mean Lifetime
- Ctime_bin=Ctime==c;
- % Detect switches in and out of this state
- a=find(diff(Ctime_bin)==1);
- b=find(diff(Ctime_bin)==-1);
- % We discard the cases where state sarts or ends ON
- if length(b)>length(a)
- b(1)=[];
- elseif length(a)>length(b)
- a(end)=[];
- elseif ~isempty(a) && ~isempty(b) && a(1)>b(1)
- b(1)=[];
- a(end)=[];
- end
- if ~isempty(a) && ~isempty(b)
- C_Durations=b-a;
- else
- C_Durations=0;
- end
- LT(task,s,k,c)=mean(C_Durations)*TR;
- end
- end
- end
- end
- P_pval=zeros(maxk-mink+1,maxk);
- LT_pval=zeros(maxk-mink+1,maxk);
- disp('Test significance between Rest and Task')
- for k=1:length(rangeK)
- disp(['Now running for ' num2str(k) ' clusters'])
- for c=1:rangeK(k)
- % Compare Probabilities
- a=squeeze(P(1,:,k,c)); % Vector containing Prob of c in Baseline
- b=squeeze(P(2,:,k,c)); % Vector containing Prob of c in Task
- stats=permutation_htest2_np([a,b],[ones(1,numel(a)) 2*ones(1,numel(b))],1000,0.05,'ttest');
- P_pval(k,c)=min(stats.pvals);
- % Compare Lifetimes
- a=squeeze(LT(1,:,k,c)); % Vector containing Lifetimes of c in Baseline
- b=squeeze(LT(2,:,k,c)); % Vector containing Lifetimes of c in Task
- stats=permutation_htest2_np([a,b],[ones(1,numel(a)) 2*ones(1,numel(b))],1000,0.05,'ttest');
- LT_pval(k,c)=min(stats.pvals);
- end
- end
- disp('%%%%% LEiDA SUCCESSFULLY COMPLETED %%%%%%%')
- disp('Saving LEiDA results')
- save LEiDA_results.mat Leading_Eig Time_all Kmeans_results P LT P_pval LT_pval rangeK
- else
- load(varargin{1})
- end
- %% 4 - Plot FC patterns and stastistics between groups
- disp(' ')
- disp('%%% PLOTS %%%%')
- disp(['Choose number of clusters between ' num2str(rangeK(1)) ' and ' num2str(rangeK(end)) ])
- Pmin_pval=min(P_pval(P_pval>0));
- LTmin_pval=min(LT_pval(LT_pval>0));
- if Pmin_pval<LTmin_pval
- [k,~]=ind2sub([length(rangeK),max(rangeK)],find(P_pval==Pmin_pval));
- else
- [k,~]=ind2sub([length(rangeK),max(rangeK)],find(LT_pval==LTmin_pval));
- end
- disp(['Note: The most significant difference is detected with K=' num2str(rangeK(k)) ' (p=' num2str(min(Pmin_pval,LTmin_pval)) ')'])
- % To correct for multiple comparisons, you can divide p by the number of
- % clusters considered
- K = input('Number of clusters: ');
- Best_Clusters=Kmeans_results{rangeK==K};
- k=find(rangeK==K);
- % Clusters are sorted according to their probability of occurrence
- ProbC=zeros(1,K);
- for c=1:K
- ProbC(c)=mean(Best_Clusters.IDX==c);
- end
- [~, ind_sort]=sort(ProbC,'descend');
- % Get the K patterns
- V=Best_Clusters.C(ind_sort,:);
- [~, N]=size(Best_Clusters.C);
- Order=[1:2:N N:-2:2];
- figure
- colormap(jet)
- % Pannel A - Plot the FC patterns over the cortex
- % Pannel B - Plot the FC patterns in matrix format
- % Pannel C - Plot the probability of each state in each condition
- % Pannel D - Plot the lifetimes of each state in each condition
- for c=1:K
- subplot(4,K,c)
- % This needs function plot_nodes_in_cortex.m and aal_cog.m
- plot_nodes_in_cortex(V(c,:))
- title({['State #' num2str(c)]})
- subplot(4,K,K+c)
- FC_V=V(c,:)'*V(c,:);
- li=max(abs(FC_V(:)));
- imagesc(FC_V(Order,Order),[-li li])
- axis square
- title('FC pattern')
- ylabel('Brain area #')
- xlabel('Brain area #')
- subplot(4,K,2*K+c)
- Rest=squeeze(P(1,:,k,ind_sort(c)));
- Task=squeeze(P(2,:,k,ind_sort(c)));
- bar([mean(Rest) mean(Task)],'EdgeColor','w','FaceColor',[.5 .5 .5])
- hold on
- % Error bar containing the standard error of the mean
- errorbar([mean(Rest) mean(Task)],[std(Rest)/sqrt(numel(Rest)) std(Task)/sqrt(numel(Task))],'LineStyle','none','Color','k')
- set(gca,'XTickLabel',{'Rest', 'Task'})
- if P_pval(k,ind_sort(c))<0.05
- plot(1.5,max([mean(Rest) mean(Task)])+.01,'*k')
- end
- if c==1
- ylabel('Probability')
- end
- box off
- subplot(4,K,3*K+c)
- Rest=squeeze(LT(1,:,k,ind_sort(c)));
- Task=squeeze(LT(2,:,k,ind_sort(c)));
- bar([mean(Rest) mean(Task)],'EdgeColor','w','FaceColor',[.5 .5 .5])
- hold on
- errorbar([mean(Rest) mean(Task)],[std(Rest)/sqrt(numel(Rest)) std(Task)/sqrt(numel(Task))],'LineStyle','none','Color','k')
- set(gca,'XTickLabel',{'Rest', 'Task'})
- if LT_pval(k,ind_sort(c))<0.05
- plot(1.5,max([mean(Rest) mean(Task)])+.01,'*k')
- end
- if c==1
- ylabel('Lifetime (seconds)')
- end
- box off
- end
LEiDA.m at commit 8676662, no license · at the source
Overview
- Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK
- Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK
- Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK
- Department of Clinical Neursciences and Mental Health, Faculty of Medicine, University of Porto, Porto, Portugal
- RISE-HEALTH (Neurosciences thematic line), Department of Clinical Neursciences and Mental Health, Faculty of Medicine, University of Porto, Porto, Portugal
- Institute for Human and Synthetic Minds, King's College London, UK
Abstract
Background: Post-COVID-19 Syndrome (PCS) is characterised by persistent fatigue, cognitive impairments, and affective symptoms, yet its underlying neural mechanisms remain poorly understood. While static neuroimaging studies have identified resting-state connectivity abnormalities in PCS, such approaches fail to capture the brain's dynamic functional organisation. This represents a missed opportunity to understand how alterations in large-scale network interactions may contribute to the fluctuating symptom profile of PCS. Cognitive and emotional processes rely on the brain's capacity to flexibly reconfigure large-scale networks over time; disruptions in this dynamic repertoire may therefore play a role in PCS pathophysiology.
Methods: Resting-state fMRI data were acquired from 20 individuals with PCS (mean age = 41.8 years, SD = 9.4) and 20 age- and sex-matched healthy controls (mean age = 40.6 years, SD = 8.1) using a multi-echo sequence. Following denoising with multi-echo independent component analysis, we applied Leading Eigenvector Dynamics Analysis (LEiDA) to identify recurrent patterns of whole-brain phase synchrony. The optimal number of dynamic brain states was determined using the Dunn index. For each state, we quantified probability of occurrence, lifetime, and transition probabilities, and mapped spatial topographies onto canonical functional networks. Group differences were assessed using ANCOVAs controlling for age, sex, and handedness. Exploratory associations with clinical symptoms, cognitive performance, and inflammatory markers were examined using both frequentist and Bayesian approaches.
Results: Five recurrent dynamic brain states were identified. Compared with controls, PCS participants showed reduced probability of occurrence and shorter lifetime of a visual/
Conclusions: PCS is associated with a reorganisation of intrinsic brain dynamics, marked by a shift from externally oriented attentional states toward limbic-DMN configurations and reduced transition flexibility. These findings suggest that PCS may involve alterations in the dynamic balance of large-scale brain systems supporting attention and internally oriented processing. While exploratory, the observed patterns are consistent with a potential link between brain-state dynamics, cognitive function, and inflammatory signalling, and provide a systems-level framework for future studies of post-viral brain dysfunction.
Reproduced under the paper's license (CC BY), from the paper cited above.
Repository
Its files are read in the Code ↔ Paper reader above, with 4 matches between paragraphs and lines of code.
juanitacabral/LEiDA
867666230bfd6d68c4945cf88df1ff9b6f115fbf, 12 May 2025Availability: 1 check, the latest on 28 September 2026: the link answers
- 28 September 2026: the link answers
45 files
- LEiDA/
LEiDA.m , MATLAB, 299 lines, 2 matches - LEiDA/
permutation_htest2_np.m , MATLAB, 198 lines - LEiDA/
plot_nodes_in_cortex.m , MATLAB, 81 lines - LEiDA_Cluster.m, MATLAB, 68 lines
- LEiDA_analysis.m, MATLAB, 81 lines
- LEiDA_data.m, MATLAB, 80 lines
- MUSIC_preadolescents/
BMRQ_p_values_Switch_120 , MATLAB, 84 lines6_exp.m - MUSIC_preadolescents/
BMRQ_pvalues_Dec2018_120 , MATLAB, 95 lines6_exp.m - MUSIC_preadolescents/
FCSwitching.m , MATLAB, 139 lines - MUSIC_preadolescents/
LEiDA_v6.m , MATLAB, 308 lines, 2 matches - MUSIC_preadolescents/
Plot_p_values.m , MATLAB, 189 lines - MUSIC_preadolescents/
SES_p_values_1206.m , MATLAB, 41 lines - MUSIC_preadolescents/
arrow3.m , MATLAB, 808 lines - MUSIC_preadolescents/
permutation_htest2_np.m , MATLAB, 198 lines - Remission from Major Depression/
Bars_nodes_States.m , MATLAB, 32 lines - Remission from Major Depression/
CaptureFigVid/ , MATLAB, 108 linesCaptureFigVid/ CaptureFigVid.m - Remission from Major Depression/
CaptureFigVid/ , MATLAB, 12 linesCaptureFigVid/ CaptureFigVid_Example.m - Remission from Major Depression/
Entropy.m , MATLAB, 167 lines - Remission from Major Depression/
FCState_okt2018.m , MATLAB, 557 lines - Remission from Major Depression/
FCSwitching_probabilitie , MATLAB, 294 liness_okt2018.m - Remission from Major Depression/
Figure4_okt_2018.m , MATLAB, 193 lines - Remission from Major Depression/
Figure5_okt_2018.m , MATLAB, 267 lines - Remission from Major Depression/
Find_switches_for_figure , MATLAB, 112 lines.m - Remission from Major Depression/
LEiDA_cluster.m , MATLAB, 66 lines - Remission from Major Depression/
LEiDA_data.m , MATLAB, 119 lines - Remission from Major Depression/
Plot_BOLD_ClusterBlocks. , MATLAB, 180 linesm - Remission from Major Depression/
Supplementary_figure_6.m , MATLAB, 38 lines - Remission from Major Depression/
Vmake.m , MATLAB, 6 lines - Remission from Major Depression/
adif.m , MATLAB, 6 lines - Remission from Major Depression/
bandpass.m , MATLAB, 31 lines - Remission from Major Depression/
barwitherr/ , MATLAB, 157 linesbarwitherr.m - Remission from Major Depression/
barwitherr/ , MATLAB, 407 linesmult_comp_perm_t1/ mult_comp_perm_t1.m - Remission from Major Depression/
convert_back_to_time.m , MATLAB, 24 lines - Remission from Major Depression/
cylinder1.m , MATLAB, 73 lines - Remission from Major Depression/
demean.m , MATLAB, 23 lines - Remission from Major Depression/
permutation_htest2_np.m , MATLAB, 215 lines - Remission from Major Depression/
permutation_htest_np_pai , MATLAB, 209 linesred.m - Remission from Major Depression/
plot_nodes_in_cortex.m , MATLAB, 81 lines - Remission from Major Depression/
plot_nodes_in_cortex_new , MATLAB, 130 lines.m - Remission from Major Depression/
video.m , MATLAB, 18 lines - adif.m, MATLAB, 6 lines
- demean.m, MATLAB, 23 lines
- dunns.m, MATLAB, 32 lines
- plot_nodes_in_cortex.m, MATLAB, 81 lines
- readme.txt, Text, 28 lines
Tracing map
Proposed by the machine: these links were found in the paper and verified at the source, without human review. The map will receive a Zenodo DOI once one of the paper's authors has validated it with their ORCID.
What the map holds:
- 1 repository of the authors' code, each at its verified commit, with its license and how the link was found in the paper;
- 44 scripts, each with its path and the digest of its content;
- 4 matches between paragraphs of the paper and lines of the code (method lexical-v1);
- neither the text of the paper nor the code itself.
Its JSON (tracing-map.json) is deposited on Zenodo with its DOI once the map is validated.
Data
No dataset and no data link were found in the paper.
Data availability
Data will be made available on request.
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.
Version 2, 28 September 2026
- Authors: added Daniel Martins (0000-0003-3731-4508); removed Daniel Martins
Version 1, 28 September 2026: the first record
Recorded: type, language, journal, volume, pages, dates, 16 authors, 9 keywords, 6 funders, 68 references.
Cite
This paper
Cahart, M.-S., O’ Daly, O., Cai, Z., Mariani, N., Borsini, A., Mondelli, V., Eiff, B., Rota, S., Nicholson, T., Rida, L., Hampshire, A., Dipasquale, O., Fernandes, L., Turkheimer, F., Williams, S. C., & Martins, D. (2026). Brain dynamics of attentional, default-mode and limbic networks are disrupted at rest in post-COVID-19 syndrome. Brain, behavior, & immunity - health, 54, 101274. https://
BibTeX
@article{cahart2026brain
author = {Cahart, Marie-Stephanie and O’ Daly, Owen and Cai, Ziyuan and Mariani, Nicole and Borsini, Alessandra and Mondelli, Valeria and Eiff, Brandi and Rota, Silvia and Nicholson, Timothy and Rida, Laila and Hampshire, Adam and Dipasquale, Ottavia and Fernandes, Lia and Turkheimer, Federico and Williams, Steven CR and Martins, Daniel},
title = {{Brain dynamics of attentional, default-mode and limbic networks are disrupted at rest in post-COVID-19 syndrome}},
journal = {Brain, behavior, \& immunity - health},
year = {2026},
month = may,
volume = {54},
pages = {101274},
publisher = {Elsevier},
issn = {2666-3546},
doi = {10.1016/
url = {https://
pmid = {42253624},
pmcid = {PMC13234210}
}
RIS
TY - JOUR
AU - Cahart, Marie-Stephanie
AU - O’ Daly, Owen
AU - Cai, Ziyuan
AU - Mariani, Nicole
AU - Borsini, Alessandra
AU - Mondelli, Valeria
AU - Eiff, Brandi
AU - Rota, Silvia
AU - Nicholson, Timothy
AU - Rida, Laila
AU - Hampshire, Adam
AU - Dipasquale, Ottavia
AU - Fernandes, Lia
AU - Turkheimer, Federico
AU - Williams, Steven CR
AU - Martins, Daniel
TI - Brain dynamics of attentional, default-mode and limbic networks are disrupted at rest in post-COVID-19 syndrome
T2 - Brain, behavior, & immunity - health
J2 - Brain Behav Immun Health
PY - 2026
DA - 2026/
VL - 54
SP - 101274
SN - 2666-3546
PB - Elsevier
DO - 10.1016/
UR - https://
LA - en
ER -
CSL-JSON
{
"id": "10.1016/
"type": "article-journal",
"title": "Brain dynamics of attentional, default-mode and limbic networks are disrupted at rest in post-COVID-19 syndrome",
"container-title": "Brain, behavior, & immunity - health",
"author": [
{
"family": "Cahart",
"given": "Marie-Stephanie"
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{
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},
{
"family": "Borsini",
"given": "Alessandra"
},
{
"family": "Mondelli",
"given": "Valeria"
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{
"family": "Eiff",
"given": "Brandi"
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{
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"given": "Silvia"
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{
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"given": "Adam"
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{
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"given": "Ottavia"
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{
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{
"family": "Turkheimer",
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},
{
"family": "Williams",
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},
{
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"given": "Daniel"
}
],
"container-title-short":
"volume": "54",
"page": "101274",
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"language": "en",
"issued": {
"date-parts": [
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]
}
}
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