OSCR

Chlorpromazine inhibits EAG1 channels by altering the interdomain coupling.

Overview

Authors: Kyle Kihn1,2,3, Ze-Jun Wang1, Xi Chen1, Mahdi Ghorbani2, Purushottam B Tiwari4, Jeffery B Klauda2,5, Tinatin I Brelidze1
ORCID iDs: Tinatin I Brelidze
  1. Department of Pharmacology and Physiology, Georgetown University Medical Center, Washington, District of Columbia
  2. Department of Chemical and Biomolecular Engineering, University of Maryland, College Park, Maryland
  3. Department of Chemistry, United States Naval Academy, Annapolis, Maryland
  4. Department of Oncology, Georgetown University Medical Center, Washington, District of Columbia
  5. Institue for Physical Science and Technology and Biophysics Graduate Program, University of Maryland, College Park, Maryland
Institutions: Georgetown University (United States); United States Naval Academy (United States); Georgetown University Medical Center (United States); University of Maryland, College Park (United States)
Journal: Biophysical journal, volume 125, issue 7, pages 1765-1778
Dates: received 9 July 2025; accepted 3 March 2026; published online 6 March 2026; in print 7 April 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1016/j.bpj.2026.03.010 · PMID 41793003 · PMCID PMC13052916 · OpenAlex W7134043217
Open access: hybrid, a free copy (OpenAlex)
Status: code on request
Categories: computational modeling (no new data) (modality), human (organism), cellular / molecular (subfield)
Methods: Statistics, Preprocessing, Connectivity, Smoothing, state filtering, decompositions
MeSH: Chlorpromazine*, Ether-A-Go-Go Potassium Channels*, Allosteric Regulation, Animals, Humans, Ion Channel Gating, Molecular Dynamics Simulation, Protein Binding, Protein Domains (* major topic)
Topic: Ion channel regulation and function (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: NCI NIH HHS (P30 CA051008, R01 CA252969); National Institutes of Health National Cancer Institute; NIA NIH HHS (T32 AG071745); National Institute of General Medical Sciences; National Institute on Aging; National Science Foundation; NIGMS NIH HHS (R01 GM124020)
Citations: cited by 1 paper (Europe PMC); 74 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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The paper's code and data availability statement is in the Data section.

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Data

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Code and data availability statement

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  • it says that the data are available on request
  • it says that the code is available on request

Read it in the paper: doi.org/10.1016/j.bpj.2026.03.010.

Versions

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Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 7 authors, 9 MeSH terms, 7 funders, 72 references.

Cite

This paper

Kihn, K., Wang, Z.-J., Chen, X., Ghorbani, M., Tiwari, P. B., Klauda, J. B., & Brelidze, T. I. (2026). Chlorpromazine inhibits EAG1 channels by altering the interdomain coupling. Biophysical journal, 125(7), 1765-1778. https://doi.org/10.1016/j.bpj.2026.03.010

BibTeX

@article{kihn2026chlorpromazine,
author = {Kihn, Kyle and Wang, Ze-Jun and Chen, Xi and Ghorbani, Mahdi and Tiwari, Purushottam B and Klauda, Jeffery B and Brelidze, Tinatin I},
title = {{Chlorpromazine inhibits EAG1 channels by altering the interdomain coupling}},
journal = {Biophysical journal},
year = {2026},
month = mar,
volume = {125},
number = {7},
pages = {1765--1778},
publisher = {The Biophysical Society},
issn = {0006-3495},
doi = {10.1016/j.bpj.2026.03.010},
url = {https://doi.org/10.1016/j.bpj.2026.03.010},
pmid = {41793003},
pmcid = {PMC13052916}
}

RIS

TY - JOUR
AU - Kihn, Kyle
AU - Wang, Ze-Jun
AU - Chen, Xi
AU - Ghorbani, Mahdi
AU - Tiwari, Purushottam B
AU - Klauda, Jeffery B
AU - Brelidze, Tinatin I
TI - Chlorpromazine inhibits EAG1 channels by altering the interdomain coupling
T2 - Biophysical journal
J2 - Biophys J
PY - 2026
DA - 2026/03/06
VL - 125
IS - 7
SP - 1765
EP - 1778
SN - 0006-3495
PB - The Biophysical Society
DO - 10.1016/j.bpj.2026.03.010
UR - https://doi.org/10.1016/j.bpj.2026.03.010
LA - en
ER -

CSL-JSON

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"title": "Chlorpromazine inhibits EAG1 channels by altering the interdomain coupling",
"container-title": "Biophysical journal",
"author": [
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"container-title-short": "Biophys J",
"volume": "125",
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"page": "1765-1778",
"DOI": "10.1016/j.bpj.2026.03.010",
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"ISSN": "0006-3495",
"publisher": "The Biophysical Society",
"URL": "https://doi.org/10.1016/j.bpj.2026.03.010",
"language": "en",
"issued": {
"date-parts": [
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}
}

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