OSCR

Immune response to adeno-associated viral vectors in a human iPSC-derived microglia chimeric mouse model.

Overview

Authors: Jan R. Detrez1, Caroline Eykens1, Gaëlle Gillet1, Manisha Padmakumar1, Sílvia Cabré1, Phil Stanley2, Julien Gasser1, Luke M. Healy1, Irena Kadiu1
ORCID iDs: Jan R. Detrez
  1. Neuroinflammation Focus Area, Neuroscience Research, UCB, Braine-l'Alleud, Belgium
  2. Early Development Statistics, UCB, Slough, UK
Journal: Cell reports methods, volume 6, issue 4, article 101362
Dates: received 3 October 2025; accepted 19 February 2026; published online 26 March 2026; in print April 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1016/j.crmeth.2026.101362 · PMID 41895259 · PMCID PMC13107050 · OpenAlex W7140722641
Open access: gold, a free copy (OpenAlex)
Status: code on request (how the code is found and verified)
Categories: genetics / omics (modality), human (organism), mouse (organism), cellular / molecular (subfield)
Methods: Statistics, Smoothing, state filtering, decompositions, Evoked potentials, fMRI & imaging
Keywords: human microglia, iPSC-derived microglia, chimeric mouse model, AAV gene therapy, innate immune response, neuroinflammation, spatial transcriptomics, mass cytometry, CNS gene delivery
MeSH: Chimera*, Dependovirus*, Genetic Vectors*, Induced Pluripotent Stem Cells*, Microglia*, Animals, Cell Differentiation, Humans, Mice (* major topic)
Topic: Neuroinflammation and Neurodegeneration Mechanisms (Neurology, Neuroscience), according to OpenAlex
Funding: UCB and the Walloon Region (Belgium)
Citations: not cited yet (Europe PMC); 37 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

The paper says that its authors' code is available on request: it was not published with the paper, so there is nothing to verify.

The paper's code and data availability statement is in the Data section.

Tracing map

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Data

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Code and data availability statement

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  • it says that the data are available on request
  • it says that the code is available on request

Read it in the paper: doi.org/10.1016/j.crmeth.2026.101362.

Versions

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Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 9 authors, 9 keywords, 9 MeSH terms, 1 funder, 37 references.

Cite

This paper

Detrez, J. R., Eykens, C., Gillet, G., Padmakumar, M., Cabré, S., Stanley, P., Gasser, J., Healy, L. M., & Kadiu, I. (2026). Immune response to adeno-associated viral vectors in a human iPSC-derived microglia chimeric mouse model. Cell reports methods, 6(4), 101362. https://doi.org/10.1016/j.crmeth.2026.101362

BibTeX

@article{detrez2026immune,
author = {Detrez, Jan R. and Eykens, Caroline and Gillet, Gaëlle and Padmakumar, Manisha and Cabré, Sílvia and Stanley, Phil and Gasser, Julien and Healy, Luke M. and Kadiu, Irena},
title = {{Immune response to adeno-associated viral vectors in a human iPSC-derived microglia chimeric mouse model}},
journal = {Cell reports methods},
year = {2026},
month = mar,
volume = {6},
number = {4},
pages = {101362},
publisher = {Elsevier},
issn = {2667-2375},
doi = {10.1016/j.crmeth.2026.101362},
url = {https://doi.org/10.1016/j.crmeth.2026.101362},
pmid = {41895259},
pmcid = {PMC13107050}
}

RIS

TY - JOUR
AU - Detrez, Jan R.
AU - Eykens, Caroline
AU - Gillet, Gaëlle
AU - Padmakumar, Manisha
AU - Cabré, Sílvia
AU - Stanley, Phil
AU - Gasser, Julien
AU - Healy, Luke M.
AU - Kadiu, Irena
TI - Immune response to adeno-associated viral vectors in a human iPSC-derived microglia chimeric mouse model
T2 - Cell reports methods
J2 - Cell Rep Methods
PY - 2026
DA - 2026/03/26
VL - 6
IS - 4
SP - 101362
SN - 2667-2375
PB - Elsevier
DO - 10.1016/j.crmeth.2026.101362
UR - https://doi.org/10.1016/j.crmeth.2026.101362
LA - en
ER -

CSL-JSON

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