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Noninvasive focal gene transfer of chemogenetic proteins in the primate brain.

Overview

Authors: Michael R. Corigliano1, T. Vincenza Parks1, Simeon S. Guretse1,2, Leila Letica1, Isabela Zimmermann Rollin1,2, Sarah K.A. Pell1, Vinicius P. Campos1, Diego Szczupak1, David J. Schaeffer1,2
ORCID iDs: Michael R. Corigliano, Simeon S. Guretse, Diego Szczupak
  1. Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15213, USA
  2. Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15213, USA
Institutions: University of Pittsburgh (United States)
Journal: Cell reports methods, volume 6, issue 6, article 101427
Dates: received 8 July 2025; accepted 2 April 2026; published online 4 May 2026; in print June 2026
Type: Brief report · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1016/j.crmeth.2026.101427 · PMID 42086048 · PMCID PMC13282649 · OpenAlex W4410741594
Open access: gold, a free copy (OpenAlex)
Preprint: doi:10.1101/2025.05.21.655304
Status: code on request
Categories: other (modality), PET / SPECT (modality), non-human primate (organism)
Methods: Connectivity, Statistics, fMRI & imaging
Keywords: common marmoset, focused ultrasound, DREADDs, circuit modulation, blood-brain barrier, adeno-associated virus, nonhuman primate, chemogenetics
MeSH: Brain*, Chemogenetics*, Gene Transfer Techniques*, Animals, Callithrix, Dependovirus, Genetic Vectors, Glucose, Positron-Emission Tomography (* major topic)
Topic: RNA Interference and Gene Delivery (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: NINDS; NIH (R21NS125372, T32 GM142630); NIGMS
Citations: not cited yet (Europe PMC); 112 references in the paper
Research resources: RRID:AB_2536614, AAV5-SYN1-HA-hM3D(Gq) RRID:Addgene_121539, AAV9-hSyn-hM3D(Gq)-mCherry RRID:Addgene_50474

Abstract

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Code

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Data

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Code and data availability statement

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Read it in the paper: doi.org/10.1016/j.crmeth.2026.101427.

Versions

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Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 9 authors, 8 keywords, 9 MeSH terms, 3 funders, 101 references, 3 RRIDs.

Cite

This paper

Corigliano, M. R., Parks, T. V., Guretse, S. S., Letica, L., Rollin, I. Z., Pell, S. K., Campos, V. P., Szczupak, D., & Schaeffer, D. J. (2026). Noninvasive focal gene transfer of chemogenetic proteins in the primate brain. Cell reports methods, 6(6), 101427. https://doi.org/10.1016/j.crmeth.2026.101427

BibTeX

@article{corigliano2026noninvasive,
author = {Corigliano, Michael R. and Parks, T. Vincenza and Guretse, Simeon S. and Letica, Leila and Rollin, Isabela Zimmermann and Pell, Sarah K.A. and Campos, Vinicius P. and Szczupak, Diego and Schaeffer, David J.},
title = {{Noninvasive focal gene transfer of chemogenetic proteins in the primate brain}},
journal = {Cell reports methods},
year = {2026},
month = may,
volume = {6},
number = {6},
pages = {101427},
publisher = {Elsevier},
issn = {2667-2375},
doi = {10.1016/j.crmeth.2026.101427},
url = {https://doi.org/10.1016/j.crmeth.2026.101427},
pmid = {42086048},
pmcid = {PMC13282649}
}

RIS

TY - JOUR
AU - Corigliano, Michael R.
AU - Parks, T. Vincenza
AU - Guretse, Simeon S.
AU - Letica, Leila
AU - Rollin, Isabela Zimmermann
AU - Pell, Sarah K.A.
AU - Campos, Vinicius P.
AU - Szczupak, Diego
AU - Schaeffer, David J.
TI - Noninvasive focal gene transfer of chemogenetic proteins in the primate brain
T2 - Cell reports methods
J2 - Cell Rep Methods
PY - 2026
DA - 2026/05/04
VL - 6
IS - 6
SP - 101427
SN - 2667-2375
PB - Elsevier
DO - 10.1016/j.crmeth.2026.101427
UR - https://doi.org/10.1016/j.crmeth.2026.101427
LA - en
ER -

CSL-JSON

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