OSCR

Reduced cortical excitability is associated with head impact severity and cognitive symptoms in adolescent football players

Overview

Authors: Kevin C Yu1,2,3, Alex I Wiesman4,5, Elizabeth M Davenport6, Laura A Flashman7, Jillian E Urban8, Srikantan S Nagarajan9, Kiran K Solingpuram Sai2, Joel D Stitzel8, Joseph A Maldjian6, Christopher T Whitlow1,3,10
ORCID iDs: Kevin C Yu
  1. Radiology Informatics and Image Processing Laboratory, Yale School of Medicine, New Haven, CT, USA
  2. Department of Radiology, Wake Forest School of Medicine, Winston-Salem, NC, USA
  3. Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA
  4. Department of Biomedical Physiology & Kinesiology, Simon Fraser University, Burnaby, BC, Canada
  5. McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, Canada
  6. Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, USA
  7. Department of Neurology, Section of Neuropsychology, Wake Forest School of Medicine, Winston-Salem, NC, USA
  8. Department of Biomedical Engineering, Wake Forest School of Medicine, Winston-Salem, NC, USA
  9. Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA
  10. Department of Biomedical Engineering, Yale School of Medicine, New Haven, CT, USA
Institutions: Yale University (United States); Wake Forest University Health Sciences (United States); Wake Forest University (United States); Montreal Neurological Institute and Hospital (Canada); Simon Fraser University (Canada); McGill University (Canada); The University of Texas Southwestern Medical Center (United States); University of California, San Francisco (United States)
Journal: n/a, volume 29, issue 2, article 114575
Dates: received 26 May 2025; accepted 24 December 2025; published online 26 December 2025
Type: Research article · Language: English
License: none stated
Identifiers: DOI 10.1016/j.isci.2025.114575 · PMCID PMC12856156 · OpenAlex W7117370860
Open access: gold, a free copy (OpenAlex)
Status: code on request
Categories: human (organism), traumatic brain injury (population), clinical / translational (subfield)
Methods: Spectral & time-frequency, Preprocessing, Connectivity, Statistics, Smoothing, state filtering, decompositions, Machine learning, Physiology & signal measures
Keywords: health sciences
Topic: Traumatic Brain Injury Research (Epidemiology, Medicine), according to OpenAlex
Funding: NINDS NIH HHS (F32 NS119375, R01 NS091602, R01 NS082453); Natural Sciences and Engineering Research Council of Canada (RGPIN-2025-04783, F32-NS119375); National Institutes of Health (R01NS082453, R01NS091602); Wake Forest School of Medicine; Canadian Institutes of Health Research (BPF-186555); Canada Research Chairs Program (CRC-2023-00300)
Citations: not cited yet (Europe PMC); 86 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (none stated) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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The paper's code and data availability statement is in the Data section.

Tracing map

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Data

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Code and data availability statement

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  • it says that the code is available on request

Read it in the paper: doi.org/10.1016/j.isci.2025.114575.

Versions

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 10 authors, 1 keyword, 6 funders, 85 references.

Cite

This paper

Yu, K. C., Wiesman, A. I., Davenport, E. M., Flashman, L. A., Urban, J. E., Nagarajan, S. S., Solingpuram Sai, K. K., Stitzel, J. D., Maldjian, J. A., & Whitlow, C. T. (2025). Reduced cortical excitability is associated with head impact severity and cognitive symptoms in adolescent football players. iScience, 29(2), 114575. https://doi.org/10.1016/j.isci.2025.114575

BibTeX

@article{yu2025reduced,
author = {Yu, Kevin C and Wiesman, Alex I and Davenport, Elizabeth M and Flashman, Laura A and Urban, Jillian E and Nagarajan, Srikantan S and Solingpuram Sai, Kiran K and Stitzel, Joel D and Maldjian, Joseph A and Whitlow, Christopher T},
title = {{Reduced cortical excitability is associated with head impact severity and cognitive symptoms in adolescent football players}},
journal = {iScience},
year = {2025},
volume = {29},
number = {2},
pages = {114575},
publisher = {Elsevier},
issn = {2589-0042},
doi = {10.1016/j.isci.2025.114575},
url = {https://doi.org/10.1016/j.isci.2025.114575},
pmcid = {PMC12856156}
}

RIS

TY - JOUR
AU - Yu, Kevin C
AU - Wiesman, Alex I
AU - Davenport, Elizabeth M
AU - Flashman, Laura A
AU - Urban, Jillian E
AU - Nagarajan, Srikantan S
AU - Solingpuram Sai, Kiran K
AU - Stitzel, Joel D
AU - Maldjian, Joseph A
AU - Whitlow, Christopher T
TI - Reduced cortical excitability is associated with head impact severity and cognitive symptoms in adolescent football players
T2 - iScience
J2 - iScience
PY - 2025
DA - 2025
VL - 29
IS - 2
SP - 114575
SN - 2589-0042
PB - Elsevier
DO - 10.1016/j.isci.2025.114575
UR - https://doi.org/10.1016/j.isci.2025.114575
LA - en
ER -

CSL-JSON

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"author": [
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