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Comparative analyses of regional and temporal transcriptomics of early human and mouse central nervous systems.

Overview

Authors: Zhe Wei1,2, Xiaojie Zhou3, Boyu Li1, Junjie Gu4, Laixiang Ge4, Fan Tang4, Mingyan Lin3,5,6,7, Ying Jin2,4
  1. Department of Reproductive Medicine, Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200135, China
  2. CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China
  3. Department of Neurobiology, School of Basic Medical Science, Nanjing Medical University, Nanjing 211166, China
  4. Department of Histoembryology, Genetics and Developmental Biology, Shanghai Key Laboratory of Reproductive Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  5. Jiangsu Provincial Key Laboratory of Biological Therapy for Organ Failure, Nanjing Medical University, Nanjing 211166, China
  6. Changzhou Medical Center, The Affiliated Changzhou Second People’s Hospital of Nanjing Medical University, Changzhou 213000, China
  7. Division of Birth Cohort Study, Fujian Maternity and Child Health Hospital, Fuzhou 350014, China
Institutions: Shanghai Jiao Tong University (China); Renji Hospital (China); Shanghai Institute of Nutrition and Health (China); University of Chinese Academy of Sciences (China); Nanjing Medical University (China); Fuzhou Maternity and Child Health Care Hospital (China); Changzhou No.2 People's Hospital (China)
Journal: iScience, volume 29, issue 4, article 115222
Dates: received 13 June 2025; accepted 27 February 2026; published online 4 March 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1016/j.isci.2026.115222 · PMID 41907405 · PMCID PMC13018895 · OpenAlex W7133512666
Open access: gold, a free copy (OpenAlex)
Status: code on request
Categories: genetics / omics (modality), human (organism), mouse (organism), developmental (subfield)
Methods: Statistics, Smoothing, state filtering, decompositions, Machine learning, Connectivity, Spectral & time-frequency
Keywords: Developmental biology, Expression study, Transcriptomics, Model organism
Topic: Single-cell and spatial transcriptomics (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: Ministry of Science and Technology of the People's Republic of China (2021YFA1100400); National Natural Science Foundation of China (National Science Foundation of China) (32300710, 82371660, 82130046); Strategic Priority Research Program of the Chinese Academy of Sciences (XDA01010102); Innovative Research Team of High-level Local Universities in Shanghai (SHSMU-ZLCX20210201, SSMU-ZLCX20180401); National Key Research and Development Program of China (2023YFC2705500, 2023YFC2705505); Shanghai's Top Priority Research Center Construction Project (2023ZZ02002)
Citations: not cited yet (Europe PMC); 82 references in the paper
Research resources: anti-Sox1 RRID:AB_2239879, anti-Otx2 RRID:AB_3076432

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

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Code and data availability statement

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Read it in the paper: doi.org/10.1016/j.isci.2026.115222.

Versions

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Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 8 authors, 4 keywords, 6 funders, 81 references, 2 RRIDs.

Cite

This paper

Wei, Z., Zhou, X., Li, B., Gu, J., Ge, L., Tang, F., Lin, M., & Jin, Y. (2026). Comparative analyses of regional and temporal transcriptomics of early human and mouse central nervous systems. iScience, 29(4), 115222. https://doi.org/10.1016/j.isci.2026.115222

BibTeX

@article{wei2026comparative,
author = {Wei, Zhe and Zhou, Xiaojie and Li, Boyu and Gu, Junjie and Ge, Laixiang and Tang, Fan and Lin, Mingyan and Jin, Ying},
title = {{Comparative analyses of regional and temporal transcriptomics of early human and mouse central nervous systems}},
journal = {iScience},
year = {2026},
month = mar,
volume = {29},
number = {4},
pages = {115222},
publisher = {Elsevier},
issn = {2589-0042},
doi = {10.1016/j.isci.2026.115222},
url = {https://doi.org/10.1016/j.isci.2026.115222},
pmid = {41907405},
pmcid = {PMC13018895}
}

RIS

TY - JOUR
AU - Wei, Zhe
AU - Zhou, Xiaojie
AU - Li, Boyu
AU - Gu, Junjie
AU - Ge, Laixiang
AU - Tang, Fan
AU - Lin, Mingyan
AU - Jin, Ying
TI - Comparative analyses of regional and temporal transcriptomics of early human and mouse central nervous systems
T2 - iScience
J2 - iScience
PY - 2026
DA - 2026/03/04
VL - 29
IS - 4
SP - 115222
SN - 2589-0042
PB - Elsevier
DO - 10.1016/j.isci.2026.115222
UR - https://doi.org/10.1016/j.isci.2026.115222
LA - en
ER -

CSL-JSON

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"language": "en",
"issued": {
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