Strategies used by two memories to share space in a small molluscan neural network.

Overview

1. Stanson-Toshok Center for Brain Function and Repair, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA
2. School of Graduate and Postdoctoral Studies, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA
3. Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA

Abstract

Distinct memories are often encoded into the same network space without destructive interference. In this study, we explored how this can be possible in Tritonia diomedea’s dorsal/ventral escape swim network during two distinct forms of non-associative learning: sensitization and habituation. Sensitization and habituation altered non-identical parameters of the escape behavior, suggesting independent encoding sites. Activity imaging with voltage-sensitive dyes found that while both memories only alter neuronal participation in the dorsal phase, sensitization is phase-specific while habituation is phase-general when altering burst intensity. Intracellular recordings found that sensitization elevates intrinsic excitability in neurons from both phases, while habituation only reduces excitability in ventral phase neurons. Phase-specific mechanisms appear to be involved—ventral phase neurons through spike frequency adaptation, while dorsal phase neurons through resting membrane potential. These results show highly specific network storage sites for distinct non-associative memories, a potential strategy for maintaining different memories without destructive interference.

Reproduced under the paper's license (CC BY-NC), from the paper cited above.

Code

The paper says that its authors' code is available on request: it was not published with the paper, so there is nothing to verify.

The paper's code and data availability statement is in the Data section.

Tracing map

A tracing map links a paper to the code its authors published: this paper has none (its code is available on request), so it has no map.

Data

Datasets cited

• data.mendeley.com/datasets/y2xsssjyvd, at Mendeley Data; found in “Data and code availability”

Data and code availability

• All data supporting the study have been deposited on Mendeley Data (http://www.doi.org/10.17632/y2xsssjyvd.1). Any additional information would be available from lead contact upon request. • All original MATLAB code supporting the study has been deposited on Mendeley Data (data.mendeley.com/datasets/y2xsssjyvd/1).

Reproduced under the paper's license (CC BY-NC), from the paper cited above.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 3 authors, 3 keywords, 1 funder, 56 references, 4 RRIDs.

Cite

This paper

Mistry, V. K., Hill, E. S., & Frost, W. N. (2026). Strategies used by two memories to share space in a small molluscan neural network. iScience, 29(4), 115355. https://doi.org/10.1016/j.isci.2026.115355

Similar papers

The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.

[1] doi:10.1371/journal.pbio.3003684 [code]

The retrieval of previously learned motor memories is facilitated by the reinstatement of default mode network manifold structures.

Journal: PLoS biology

In common: 4 references

[2] doi:10.1016/j.isci.2026.117375 [code]

Motor priming is associated with widespread recruitment into neural ensembles and more rapid ensemble transitions.

Journal: iScience

In common: other, 2 references

[3] doi:10.1016/j.isci.2026.115949 [code]

The dual interpretation of edge time series: Time-varying connectivity versus statistical interaction.

Journal: iScience

In common: 2 references

[4] doi:10.1038/s41467-026-74791-6

Visual learning at fast and slow timescales is driven by distinct plasticity rules in primate inferotemporal cortex.

Journal: Nature communications

In common: 2 references

[5] doi:10.1038/s41467-026-74231-5 [code]

Threat intensity shapes cortical engram architecture supporting remote memory retrieval.

Journal: Nature communications

In common: 2 references

[6] doi:10.3389/fncel.2026.1769317

Transcriptomic signatures of hippocampal active place avoidance memory maintenance.

Journal: Frontiers in cellular neuroscience

In common: 2 references

[7] doi:10.1002/advs.202521254 [code]

Persistently Increased Expression of PKMzeta and Unbiased Gene Expression Profiles Identify Hippocampal Molecular Traces of a Long-Term Active Place Avoidance Memory and "Shadow" Proteins.

Journal: Advanced science (Weinheim, Baden-Wurttemberg, Germany)

In common: 2 references

[8] doi:10.1016/j.isci.2026.116665 [code]

Exposure to non-nestmate odors changes the odorant receptor profile in <i>Acromyrmex echinatior</i> leaf-cutting ants.

Journal: iScience

In common: other, 1 reference

[9] doi:10.1016/j.isci.2026.117136 [code]

Complex pectoral-fin-driven locomotion underlies refined visuomotor behavior in the cichlid <i>Astatotilapia burtoni</i>.

Journal: iScience

In common: other, 1 reference

[10] doi:10.1126/sciadv.aec6922 [code]

A sensorimotor instability drives a locomotor transition during fish development.

Journal: Science advances

In common: other, 1 reference

Contribute

The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.

Request its removal

To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).

Discussion: questions and error reports about this paper and its code, from signed-in readers and its authors. It opens with sign-in.

Reproductions: reports from readers who ran the authors' code: what they reproduced, with which environment, commit and data. It opens with sign-in.

Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.