C2CD5 in noradrenergic neurons regulates thermogenesis and lipid homeostasis via norepinephrine secretion.
Overview
- Department of Biomedical Sciences, Faculty of Biology and Medicine, University of Lausanne, Lausanne, 1005 Vaud, Switzerland
- Department of Otorhinolaryngology-Head and Neck Surgery, Lausanne University Hospital, University of Lausanne, Lausanne, 1005 Vaud, Switzerland
Abstract
Thermogenesis and lipid utilization are important components of energy expenditure; they are regulated within a complex network of behavioral, hormonal, and molecular pathways that collectively maintain energy balance. Norepinephrine (NE) released by sympathetic neurons plays a critical role in modulating these processes. Here, we identify the trafficking protein C2CD5 as a key regulator of NE secretion and thermogenic function. C2CD5 is expressed in dopamine β-hydroxylase (DBH)-positive sympathetic neurons, and its expression is suppressed by obesogenic diets. Using conditional knockout mice lacking C2CD5 in DBH+ neurons, we show that loss of C2CD5 reduces NE secretion, impairs thermogenesis, lowers energy expenditure, and promotes adiposity. These effects are mitigated by NE supplementation. Our findings reveal a functional role for C2CD5 in linking sympathetic tone to systemic metabolic regulation and suggest it may represent a targetable node for metabolic disorders.
Reproduced under the paper's license (CC BY), from the paper cited above.
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Version 1, 30 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 4 authors, 3 keywords, 3 funders, 43 references, 6 RRIDs.
Cite
This paper
Gavini, C. K., Labouèbe, G., Gorostidi, F., & Mansuy-Aubert, V. (2026). C2CD5 in noradrenergic neurons regulates thermogenesis and lipid homeostasis via norepinephrine secretion. iScience, 29(4), 115446. https://
BibTeX
@article{gavini2026c2cd5
author = {Gavini, Chaitanya K and Labouèbe, Gwenaël and Gorostidi, François and Mansuy-Aubert, Virginie},
title = {{C2CD5 in noradrenergic neurons regulates thermogenesis and lipid homeostasis via norepinephrine secretion}},
journal = {iScience},
year = {2026},
month = mar,
volume = {29},
number = {4},
pages = {115446},
publisher = {Elsevier},
issn = {2589-0042},
doi = {10.1016/
url = {https://
pmid = {42006349},
pmcid = {PMC13090686}
}
RIS
TY - JOUR
AU - Gavini, Chaitanya K
AU - Labouèbe, Gwenaël
AU - Gorostidi, François
AU - Mansuy-Aubert, Virginie
TI - C2CD5 in noradrenergic neurons regulates thermogenesis and lipid homeostasis via norepinephrine secretion
T2 - iScience
J2 - iScience
PY - 2026
DA - 2026/
VL - 29
IS - 4
SP - 115446
SN - 2589-0042
PB - Elsevier
DO - 10.1016/
UR - https://
LA - en
ER -
CSL-JSON
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"family": "Gavini",
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"language": "en",
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