OSCR

Phenotypic screening of human iPSC-derived neurons identifies thienopyridones as neuritogenic small molecules.

Overview

Authors: Keiko Imamura1,2,3,4, Hiroshi Yukikate2,5, Takeshi Hioki2,6, Aya Okusa1,4, Keisuke Shibata2,5, Iñigo Narvaiza2,6, Akira Kaieda7, Bunnai Saito7, Nozomu Sakai7, Dang Ngoc Anh Suong1,3, Takeshi Niki1,3, Yuko Arioka8, Norio Ozaki8, Haruhisa Inoue1,2,3,4
ORCID iDs: Haruhisa Inoue
  1. Center for iPS Cell Research and Application (CiRA), Kyoto University, 53 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan
  2. Takeda-CiRA (T-CiRA) Joint Program, 2-26-1, Muraoka-Higashi, Fujisawa 251-8555, Japan
  3. iPSC-based Drug Discovery and Development Team, RIKEN BioResource Research Center (BRC), 1-7 Hikaridai, Seika-cho, Soraku-gun, Kyoto 619-0237, Japan
  4. Medical-risk Avoidance Based on iPS Cells Team, RIKEN Center for Advanced Intelligence Project (AIP), 53 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan
  5. Global Advanced Platform, Takeda Pharmaceutical Company Limited, 2-26-1, Muraoka-Higashi, Fujisawa 251-8555, Japan
  6. Neuroscience Drug Discovery Unit, Takeda Pharmaceutical Company Limited, 2-26-1, Muraoka-Higashi, Fujisawa 251-8555, Japan
  7. New Chemical Entity Production Laboratories, Takeda Pharmaceutical Company Limited, 2-26-1, Muraoka-Higashi, Fujisawa 251-8555, Japan
  8. Department of Psychiatry, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan
Institutions: Kyoto University (Japan); RIKEN BioResource Research Center (Japan); RIKEN Center for Advanced Intelligence Project (Japan); Center for iPS Cell Research and Application, Kyoto University (Japan); Takeda (Japan) (Japan); Nagoya University (Japan)
Journal: iScience, volume 29, issue 5, article 115529
Dates: received 25 August 2025; accepted 26 March 2026; published online 30 March 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1016/j.isci.2026.115529 · PMID 42028031 · PMCID PMC13099497 · OpenAlex W7143888594
Open access: gold, a free copy (OpenAlex)
Status: code on request (how the code is found and verified)
Categories: human (organism), cellular / molecular (subfield)
Methods: Statistics
Keywords: biological sciences, neuroscience, pharmacology, stem cells research
Topic: Phosphodiesterase function and regulation (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: Japan Agency for Medical Research and Development (JP23bm1323001, JP22bm0804034, JP23bm1423014, JP24wm0625501, JP25bm1423029, JP24bm1123047, JP24wm0625201, JP25wm0625518); MHLW Intractable Diseases Program (JPMH24FC1008); Takeda Pharmaceutical Company
Citations: not cited yet (Europe PMC); 33 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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The paper's code and data availability statement is in the Data section.

Tracing map

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Data

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Code and data availability statement

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  • it says that the data are available on request
  • it says that the code is available on request

Read it in the paper: doi.org/10.1016/j.isci.2026.115529.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 14 authors, 4 keywords, 3 funders, 33 references.

Cite

This paper

Imamura, K., Yukikate, H., Hioki, T., Okusa, A., Shibata, K., Narvaiza, I., Kaieda, A., Saito, B., Sakai, N., Anh Suong, D. N., Niki, T., Arioka, Y., Ozaki, N., & Inoue, H. (2026). Phenotypic screening of human iPSC-derived neurons identifies thienopyridones as neuritogenic small molecules. iScience, 29(5), 115529. https://doi.org/10.1016/j.isci.2026.115529

BibTeX

@article{imamura2026phenotypic,
author = {Imamura, Keiko and Yukikate, Hiroshi and Hioki, Takeshi and Okusa, Aya and Shibata, Keisuke and Narvaiza, Iñigo and Kaieda, Akira and Saito, Bunnai and Sakai, Nozomu and Anh Suong, Dang Ngoc and Niki, Takeshi and Arioka, Yuko and Ozaki, Norio and Inoue, Haruhisa},
title = {{Phenotypic screening of human iPSC-derived neurons identifies thienopyridones as neuritogenic small molecules}},
journal = {iScience},
year = {2026},
month = mar,
volume = {29},
number = {5},
pages = {115529},
publisher = {Elsevier},
issn = {2589-0042},
doi = {10.1016/j.isci.2026.115529},
url = {https://doi.org/10.1016/j.isci.2026.115529},
pmid = {42028031},
pmcid = {PMC13099497}
}

RIS

TY - JOUR
AU - Imamura, Keiko
AU - Yukikate, Hiroshi
AU - Hioki, Takeshi
AU - Okusa, Aya
AU - Shibata, Keisuke
AU - Narvaiza, Iñigo
AU - Kaieda, Akira
AU - Saito, Bunnai
AU - Sakai, Nozomu
AU - Anh Suong, Dang Ngoc
AU - Niki, Takeshi
AU - Arioka, Yuko
AU - Ozaki, Norio
AU - Inoue, Haruhisa
TI - Phenotypic screening of human iPSC-derived neurons identifies thienopyridones as neuritogenic small molecules
T2 - iScience
J2 - iScience
PY - 2026
DA - 2026/03/30
VL - 29
IS - 5
SP - 115529
SN - 2589-0042
PB - Elsevier
DO - 10.1016/j.isci.2026.115529
UR - https://doi.org/10.1016/j.isci.2026.115529
LA - en
ER -

CSL-JSON

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