OSCR

Huntingtin polyglutamine expansions misdirect axonal transport by perturbing motor and adaptor recruitment.

Code ↔ Paper

7 matches between paragraphs of the paper and lines of its authors' code, computed by the harvester (lexical-v1). Click a colored paragraph or line to see its counterpart.

The 7 matches
  1. [1] § STAR★Methods › Quantification and statistical analysis › Flux analysis ↔ Organelle_motility_TrackMate/TrackMate_to_kymo_and_flux_v4.m, lines 112–195 · score 0.85 · somal side, distal side, trajectory entered, anterograde flux, retrograde flux, box width
  2. [2] § STAR★Methods › Quantification and statistical analysis › Flux analysis ↔ Organelle_motility_KymoButler/TrackMate_to_kymo_and_flux_v4_KB.m, lines 138–223 · score 0.84 · somal side, distal side, trajectory entered, anterograde flux, retrograde flux, box width
  3. [3] § Results › Pathogenic HTT-polyQ increases the fraction of anterograde-directed lysosomes ↔ Organelle_motility_TrackMate/TrackMate_to_kymo_and_flux_v4.m, lines 112–195 · score 0.66 · somal side, soma side, distal side, KymoButler, TrackMate, exited
  4. [4] § Results › Pathogenic HTT-polyQ increases the fraction of anterograde-directed lysosomes ↔ Organelle_motility_KymoButler/TrackMate_to_kymo_and_colour_coded_flux_KB.m, lines 163–247 · score 0.64 · somal side, soma side, distal side, KymoButler, exited, flux
  5. [5] § STAR★Methods › Method details › Endosome immunofluorescence and imaging ↔ Organelle_motility_TrackMate/Plot_xk_yk_per_cell_stationary_track_v2.m, lines 305–383 · score 0.55 · Gaussian mixture, Gaussian fits, density, cell, fraction
  6. [6] § STAR★Methods › Method details › Endosome immunofluorescence and imaging ↔ Organelle_motility_KymoButler/Analyze_processive_motility_em_bstrp_4kchoose.m, lines 951–1035 · score 0.54 · Gaussian mixture, Gaussian fits, density
  7. [7] § STAR★Methods › Quantification and statistical analysis › TrackMate analysis parameters ↔ Organelle_motility_TrackMate/Analyze_Trackmate_motility_v2_em_master.m, lines 79–167 · score 0.50 · Weka Segmentation, TrackMate, mitochondria, trajectories, cargoes

Paper

Loaded from Europe PMC by your browser, not stored by OSCR: doi.org · Europe PMC

The paper is loaded when this pane is shown.

The authors' code

MATLAB · 573 lines · 33 KB · no license · 2 matches

The registry keeps no copy of this file: its repository has no license, so its authors keep all their rights to it. Your browser shows it from its source, with JavaScript.

It can be read at the source: Organelle_motility_TrackMate/TrackMate_to_kymo_and_flux_v4.m.

Overview

Authors: Emily NP Prowse1, Brooke A Turkalj1, Muriel Sébastien1,2, Lale Gursu1, Daniel Beaudet1, Jia Feng3, Chengqian Zhou1, Heidi M McBride4, Gary J Brouhard2,5, Mahmoud A Pouladi3, Adam G Hendricks1,5
ORCID iDs: Muriel Sébastien, Jia Feng, Adam G Hendricks
  1. Department of Bioengineering, McGill University, Montréal, QC, Canada
  2. Department of Biology, McGill University, Montréal, QC, Canada
  3. Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada
  4. Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montréal, QC, Canada
  5. Centre de Recherche en Biologie Structurale, McGill University, Montréal, QC, Canada
Institutions: McGill University (Canada); University of British Columbia (Canada); Montreal Neurological Institute and Hospital (Canada)
Journal: iScience, volume 29, issue 6, article 115748
Dates: received 10 April 2024; accepted 13 April 2026; published online 17 April 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1016/j.isci.2026.115748 · PMID 42181265 · PMCID PMC13194641 · OpenAlex W4394785919
Open access: gold, a free copy (OpenAlex)
Preprint: doi:10.1101/2024.04.12.589210
Status: code verified
Categories: cellular / molecular (subfield)
Methods: Statistics, Evoked potentials, fMRI & imaging, Smoothing, state filtering, decompositions
Keywords: Molecular network, Molecular neuroscience, Cellular neuroscience
Topic: Genetic Neurodegenerative Diseases (Cellular and Molecular Neuroscience, Neuroscience), according to OpenAlex
Funding: Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Quebec Health Research Fund
Citations: not cited yet (Europe PMC); 73 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Repository

Its files are read in the Code ↔ Paper reader above, with 7 matches between paragraphs and lines of code.

hendricks-lab/emily-codes

License: none: the authors keep all their rights
State: the link answers, verified on 29 September 2026
Evidence: files inventoried
Commit: 6f57e0abe77a1ab2e09da46bb5c6023c589c09db, 30 April 2024
Languages: MATLAB (40)
Size: 47 files, 40 scripts
Software Heritage: not archived
Found in: “Data and code availability”
Holds: README
Not found: license file, CITATION.cff, environment file, tests, continuous integration, documentation
Tools: Statistics and Machine Learning Toolbox (17 files), Optimization Toolbox (5 files), Signal Processing Toolbox (3 files), Curve Fitting Toolbox (1 file)
Availability: 1 check, the latest on 29 September 2026: the link answers
  • 29 September 2026: the link answers
41 files, not copied: shown from their source

OSCR keeps no copy of these files: this repository has no license that allows it. The reader above shows each one from its source, fetched by your browser at commit 6f57e0a, when its fingerprint is the one OSCR verified. How this works.

At the source: github.com/hendricks-lab/emily-codes/releases

The paper's code and data availability statement is in the Data section.

Tracing map

Proposed by the machine: these links were found in the paper and verified at the source, without human review. The map will receive a Zenodo DOI once one of the paper's authors has validated it with their ORCID.

What the map holds:

  • 1 repository of the authors' code, each at its verified commit, with its license and how the link was found in the paper;
  • 40 scripts, each with its path and the digest of its content;
  • 7 matches between paragraphs of the paper and lines of the code (method lexical-v1);
  • neither the text of the paper nor the code itself.

Its JSON (tracing-map.json) is deposited on Zenodo with its DOI once the map is validated.

Data

No dataset and no data link were found in the paper.

Code and data availability statement

The paper has a code and data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • it points to the authors' code: hendricks-lab/emily-codes
  • it says that the data are available on request
  • it says that the code is available on request

Read it in the paper: doi.org/10.1016/j.isci.2026.115748.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 29 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 11 authors, 3 keywords, 3 funders, 72 references.

Cite

This paper

Prowse, E. N., Turkalj, B. A., Sébastien, M., Gursu, L., Beaudet, D., Feng, J., Zhou, C., McBride, H. M., Brouhard, G. J., Pouladi, M. A., & Hendricks, A. G. (2026). Huntingtin polyglutamine expansions misdirect axonal transport by perturbing motor and adaptor recruitment. iScience, 29(6), 115748. https://doi.org/10.1016/j.isci.2026.115748

BibTeX

@article{prowse2026huntingtin,
author = {Prowse, Emily NP and Turkalj, Brooke A and Sébastien, Muriel and Gursu, Lale and Beaudet, Daniel and Feng, Jia and Zhou, Chengqian and McBride, Heidi M and Brouhard, Gary J and Pouladi, Mahmoud A and Hendricks, Adam G},
title = {{Huntingtin polyglutamine expansions misdirect axonal transport by perturbing motor and adaptor recruitment}},
journal = {iScience},
year = {2026},
month = apr,
volume = {29},
number = {6},
pages = {115748},
publisher = {Elsevier},
issn = {2589-0042},
doi = {10.1016/j.isci.2026.115748},
url = {https://doi.org/10.1016/j.isci.2026.115748},
pmid = {42181265},
pmcid = {PMC13194641}
}

RIS

TY - JOUR
AU - Prowse, Emily NP
AU - Turkalj, Brooke A
AU - Sébastien, Muriel
AU - Gursu, Lale
AU - Beaudet, Daniel
AU - Feng, Jia
AU - Zhou, Chengqian
AU - McBride, Heidi M
AU - Brouhard, Gary J
AU - Pouladi, Mahmoud A
AU - Hendricks, Adam G
TI - Huntingtin polyglutamine expansions misdirect axonal transport by perturbing motor and adaptor recruitment
T2 - iScience
J2 - iScience
PY - 2026
DA - 2026/04/17
VL - 29
IS - 6
SP - 115748
SN - 2589-0042
PB - Elsevier
DO - 10.1016/j.isci.2026.115748
UR - https://doi.org/10.1016/j.isci.2026.115748
LA - en
ER -

CSL-JSON

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