The calcium-binding protein S100β regulates synaptic plasticity in the visual cortex.

Overview

Authors: Yanis Inglebert^1,2, Rafael Sanz-Gálvez^1,2, Arlette Kolta^1,2,3

ORCID iDs: Arlette Kolta

Department of Neurosciences, Université de Montréal, Montréal, QC H3T 1J4, Canada
Centre Interdisciplinaire de recherche sur le cerveau et l’apprentissage (CIRCA), Montréal, QC H3T1J4, Canada
Faculté de Médecine Dentaire, Université de Montréal, Montréal, QC H3T 1J4, Canada

Institutions: Université de Montréal (Canada)

Journal: iScience, volume 29, issue 5, article 115793

Dates: received 13 August 2025; accepted 15 April 2026; published online 17 April 2026

Type: Research article · Language: English

License: CC BY-NC

Identifiers: DOI 10.1016/j.isci.2026.115793 · PMID 42111179 · PMCID PMC13157013 · OpenAlex W7154716387

Open access: gold, a free copy (OpenAlex)

Status: code on request

Categories: cellular / molecular (subfield)

Methods: Statistics

Keywords: neuroscience, systems neuroscience, cell biology

Topic: S100 Proteins and Annexins (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex

Funding: Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research

Citations: not cited yet (Europe PMC); 72 references in the paper

Research resources: Rabbit anti Kv4.2 RRID:AB_2040176, Mouse anti-S100β RRID:AB_477499, RRID:IMSR_EM:05301, Mouse: C57BL/6J RRID:IMSR_JAX:000664, Igor Pro RRID:SCR_000325, SPSS 26-29 RRID:SCR_002865, ImageJ RRID:SCR_003070, Axopatch RRID:SCR_018866

Abstract

Synaptic plasticity is a fundamental mechanism of memory storage in the brain. Among the rules governing changes in synaptic strength, spike timing-dependent plasticity (STDP) stands out for its physiological relevance in vivo. Ubiquitous across brain regions and neuronal types, STDP is influenced by factors, such as neuromodulation, extracellular calcium levels, and activity patterns. However, the role of astrocytes remains relatively understudied, despite their involvement in regulating synaptic transmission and neuronal excitability through gliotransmitter release. S100β is a calcium-binding protein, mainly found in glial cells, allowing it to influence extracellular Ca2+ concentration and potentially all Ca2+-dependent plasticity processes. Building on our previous research in the visual cortex, where we examined the regulation of neuronal excitability by S100β, we chose to further investigate the role of astrocytes and S100β in synaptic plasticity at layer 2/3–layer 5 synapses in the visual cortex. We demonstrated that S100β is an important regulator of long-term potentiation.

Reproduced under the paper's license (CC BY-NC), from the paper cited above.

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Version 1, 29 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 3 authors, 3 keywords, 2 funders, 72 references, 8 RRIDs.

Cite

This paper

Inglebert, Y., Sanz-Gálvez, R., & Kolta, A. (2026). The calcium-binding protein S100β regulates synaptic plasticity in the visual cortex. iScience, 29(5), 115793. https://doi.org/10.1016/j.isci.2026.115793

BibTeX

@article{inglebert2026calcium, author = {Inglebert, Yanis and Sanz-Gálvez, Rafael and Kolta, Arlette}, title = {{The calcium-binding protein S100β regulates synaptic plasticity in the visual cortex}}, journal = {iScience}, year = {2026}, month = apr, volume = {29}, number = {5}, pages = {115793}, publisher = {Elsevier}, issn = {2589-0042}, doi = {10.1016/j.isci.2026.115793}, url = {https://doi.org/10.1016/j.isci.2026.115793}, pmid = {42111179}, pmcid = {PMC13157013} }

RIS

TY - JOUR AU - Inglebert, Yanis AU - Sanz-Gálvez, Rafael AU - Kolta, Arlette TI - The calcium-binding protein S100β regulates synaptic plasticity in the visual cortex T2 - iScience J2 - iScience PY - 2026 DA - 2026/04/17 VL - 29 IS - 5 SP - 115793 SN - 2589-0042 PB - Elsevier DO - 10.1016/j.isci.2026.115793 UR - https://doi.org/10.1016/j.isci.2026.115793 LA - en ER -

CSL-JSON

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