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High intensity 40 Hz flicker improves amyloid pathology and cognition with autophagy in 3xTg mice.

Overview

Authors: Zhongya Gu1, Yufeng Fu1, Yaqi Huang1, Chengchao Zuo2, Yu Song1, Yu Guo1, Huan Cao1, Yongsheng Jiang3, Furong Wang1,4,5
ORCID iDs: Furong Wang
  1. Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China
  2. Department of Rehabilitation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China
  3. Cancer Center of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China
  4. School of Nursing, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China
  5. Key Laboratory of Vascular Aging (HUST), Ministry of Education, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China
Journal: iScience, volume 29, issue 6, article 115994
Dates: received 23 October 2025; accepted 30 April 2026; published online 25 May 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1016/j.isci.2026.115994 · PMID 42239728 · PMCID PMC13226788 · OpenAlex W7162305481
Open access: gold, a free copy (OpenAlex)
Status: code on request
Categories: mouse (organism), Alzheimer's / dementia (population)
Methods: Statistics, fMRI & imaging
Keywords: photomedicine, biological sciences, neuroscience, cognitive neuroscience, techniques in neuroscience
Topic: Planarian Biology and Electrostimulation (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: Huazhong University of Science and Technology; National Natural Science Foundation of China (81974218); National Key Research and Development Program of China; Tongji Hospital; Hubei Province Department of Science and Technology (2020BCA089)
Citations: not cited yet (Europe PMC); 75 references in the paper
Research resources: RRID:AB_10624872, RRID:AB_10888105, Chicken polyclonal Anti-NeuN antibody RRID:AB_11205760, Rabbit Polyclonal Anti-NMDAR2B antibody RRID:AB_1658870, Rabbit monoclonal Anti-NMDAR1 antibody RRID:AB_1904067, RRID:AB_2070042, Mouse monoclonal Anti-GAPDH antibody RRID:AB_2107436, RRID:AB_2112295, RRID:AB_228307, RRID:AB_228341, RRID:AB_2286949, RRID:AB_2534069, RRID:AB_2534079, RRID:AB_2564653, Rabbit monoclonal Anti-Bcl-2 antibody RRID:AB_2715467, RRID:AB_2810880, Mouse monoclonal Anti-β-actin antibody RRID:AB_2814866, Rabbit monoclonal Anti-LC3 antibody RRID:AB_2827794, RRID:AB_2832244, Mouse monoclonal Anti-Bax antibody RRID:AB_2848213, RRID:AB_2895158, Rabbit polyclonal GFAP antibody RRID:AB_305808, RRID:AB_3081853, RRID:AB_330330, RRID:AB_330331, Rabbit monoclonal Anti-mTOR antibody RRID:AB_330978, RRID:AB_344892, Hoechst 33342 RRID:AB_3591810, Rabbit polyclonal Anti-LC3B antibody RRID:AB_796155, RRID:MMRRC_034830-JAX

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

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Code and data availability statement

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Read it in the paper: doi.org/10.1016/j.isci.2026.115994.

Versions

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Version 2, 28 September 2026

  • Authors: added Furong Wang (0000-0001-8693-7301); removed Furong Wang

Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 9 authors, 5 keywords, 5 funders, 75 references, 30 RRIDs.

Cite

This paper

Gu, Z., Fu, Y., Huang, Y., Zuo, C., Song, Y., Guo, Y., Cao, H., Jiang, Y., & Wang, F. (2026). High intensity 40 Hz flicker improves amyloid pathology and cognition with autophagy in 3xTg mice. iScience, 29(6), 115994. https://doi.org/10.1016/j.isci.2026.115994

BibTeX

@article{gu2026high,
author = {Gu, Zhongya and Fu, Yufeng and Huang, Yaqi and Zuo, Chengchao and Song, Yu and Guo, Yu and Cao, Huan and Jiang, Yongsheng and Wang, Furong},
title = {{High intensity 40 Hz flicker improves amyloid pathology and cognition with autophagy in 3xTg mice}},
journal = {iScience},
year = {2026},
month = may,
volume = {29},
number = {6},
pages = {115994},
publisher = {Elsevier},
issn = {2589-0042},
doi = {10.1016/j.isci.2026.115994},
url = {https://doi.org/10.1016/j.isci.2026.115994},
pmid = {42239728},
pmcid = {PMC13226788}
}

RIS

TY - JOUR
AU - Gu, Zhongya
AU - Fu, Yufeng
AU - Huang, Yaqi
AU - Zuo, Chengchao
AU - Song, Yu
AU - Guo, Yu
AU - Cao, Huan
AU - Jiang, Yongsheng
AU - Wang, Furong
TI - High intensity 40 Hz flicker improves amyloid pathology and cognition with autophagy in 3xTg mice
T2 - iScience
J2 - iScience
PY - 2026
DA - 2026/05/25
VL - 29
IS - 6
SP - 115994
SN - 2589-0042
PB - Elsevier
DO - 10.1016/j.isci.2026.115994
UR - https://doi.org/10.1016/j.isci.2026.115994
LA - en
ER -

CSL-JSON

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