OSCR

Microglia and its P2RY12 receptors regulate seizure severity.

Overview

Authors: Leigh Ellen Fremuth1,2,3, Synphane Gibbs-Shelton1,4, Madison Doceti5, Aida Oryza Lopez-Ortiz1,2,5,6, Abigayle Duffy1,2,3,5,6, William A Mills III1,2,3, Ronald P Gaykema4, Kiran Singh4, Audrey Nguyen2, Sophia Cheng2, Edward Perez-Reyes4, Ukpong B Eyo1,2,3,5,6
ORCID iDs: Ukpong B Eyo
  1. Brain Immunology and Glia Center, University of Virginia, Charlottesville, VA, USA
  2. Department of Neuroscience, University of Virginia, Charlottesville, VA, USA
  3. Cardiovascular Research Center, University of Virginia, Charlottesville, VA, USA
  4. Department of Pharmacology, University of Virginia, Charlottesville, VA, USA
  5. Department of Microbiology, Immunology and Cancer, University of Virginia, Charlottesville, VA, USA
  6. Neuroscience Graduate Program, University of Virginia, Charlottesville, VA, USA
Institutions: University of Virginia (United States)
Journal: iScience, volume 29, issue 7, article 116563
Dates: received 13 January 2026; accepted 9 June 2026; published online 2 July 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1016/j.isci.2026.116563 · PMID 42491696 · PMCID PMC13378365 · OpenAlex W4417309907
Open access: gold, a free copy (OpenAlex)
Preprint: doi:10.64898/2025.12.11.693689
Status: code on request
Categories: mouse (organism), epilepsy (population), cellular / molecular (subfield)
Methods: Statistics, Evoked potentials, fMRI & imaging
Keywords: microglia, seizures, P2RY12, FIRE mice, border-associated macrophages, excitability, neuronal activity
Topic: Neuroinflammation and Neurodegeneration Mechanisms (Neurology, Neuroscience), according to OpenAlex
Funding: NINDS NIH HHS (R01 NS119243, R61 NS112549, R33 NS112549); National Institutes of Health; NHLBI NIH HHS (T32 HL007284); HHMI; NIGMS NIH HHS (T32 GM148379); The Owens Family Foundation
Citations: not cited yet (Europe PMC); 60 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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The paper's code and data availability statement is in the Data section.

Tracing map

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Data

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Code and data availability statement

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  • it says that the data are available on request
  • it says that the code is available on request

Read it in the paper: doi.org/10.1016/j.isci.2026.116563.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 2, 28 September 2026

  • Authors: added Ukpong B Eyo (0000-0002-1294-475X); removed Ukpong B Eyo

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 12 authors, 7 keywords, 6 funders, 60 references.

Cite

This paper

Fremuth, L. E., Gibbs-Shelton, S., Doceti, M., Lopez-Ortiz, A. O., Duffy, A., Mills, W. A., Gaykema, R. P., Singh, K., Nguyen, A., Cheng, S., Perez-Reyes, E., & Eyo, U. B. (2026). Microglia and its P2RY12 receptors regulate seizure severity. iScience, 29(7), 116563. https://doi.org/10.1016/j.isci.2026.116563

BibTeX

@article{fremuth2026microglia,
author = {Fremuth, Leigh Ellen and Gibbs-Shelton, Synphane and Doceti, Madison and Lopez-Ortiz, Aida Oryza and Duffy, Abigayle and Mills, William A and Gaykema, Ronald P and Singh, Kiran and Nguyen, Audrey and Cheng, Sophia and Perez-Reyes, Edward and Eyo, Ukpong B},
title = {{Microglia and its P2RY12 receptors regulate seizure severity}},
journal = {iScience},
year = {2026},
month = jul,
volume = {29},
number = {7},
pages = {116563},
publisher = {Elsevier},
issn = {2589-0042},
doi = {10.1016/j.isci.2026.116563},
url = {https://doi.org/10.1016/j.isci.2026.116563},
pmid = {42491696},
pmcid = {PMC13378365}
}

RIS

TY - JOUR
AU - Fremuth, Leigh Ellen
AU - Gibbs-Shelton, Synphane
AU - Doceti, Madison
AU - Lopez-Ortiz, Aida Oryza
AU - Duffy, Abigayle
AU - Mills, William A
AU - Gaykema, Ronald P
AU - Singh, Kiran
AU - Nguyen, Audrey
AU - Cheng, Sophia
AU - Perez-Reyes, Edward
AU - Eyo, Ukpong B
TI - Microglia and its P2RY12 receptors regulate seizure severity
T2 - iScience
J2 - iScience
PY - 2026
DA - 2026/07/02
VL - 29
IS - 7
SP - 116563
SN - 2589-0042
PB - Elsevier
DO - 10.1016/j.isci.2026.116563
UR - https://doi.org/10.1016/j.isci.2026.116563
LA - en
ER -

CSL-JSON

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