OSCR

Dynamic interactions with neuroblasts promote oligodendrocyte progenitor migration to injured cortex.

Overview

Authors: Yuriko Sobu1, Nodoka Ito1, Edward William Ko Uy1, Mayaka Hashimoto2, Kazuya Kuboyama2, Chihiro Akazawa3, Shinsuke Shibata4, Hirohide Takebayashi5, Hideyuki Okano6, Vicente Herranz-Pérez7, Kazunobu Sawamoto2,8, Naoko Kaneko1
  1. Laboratory of Neuronal Regeneration, Graduate School of Brain Science, Doshisha University, Kyotanabe 610-0394, Japan
  2. Department of Developmental and Regenerative Neurobiology, Institute of Brain Science, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan
  3. Intractable Disease Research Center, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan
  4. Division of Microscopic Anatomy, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
  5. Center for Anatomical Studies, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan
  6. Keio University Regenerative Medicine Research Center, Research Gate Building TONOMACHI 2-4F, 3-25-10 Tonomachi, Kawasaki-Ku, Kawasaki, Kanagawa 210-0821, Japan
  7. Department of Cell Biology, Functional Biology and Physical Anthropology, University of Valencia, Burjassot, Spain
  8. Division of Neural Development and Regeneration, National Institute of Physiological Sciences, Okazaki 444-8585, Japan
Journal: iScience, volume 29, issue 9, article 117318
Dates: received 23 March 2026; accepted 7 August 2026; published online 24 August 2026
Type: Research article · Language: English
License: CC BY
Identifiers: DOI 10.1016/j.isci.2026.117318 · PMID 42698966 · PMCID PMC13542502 · OpenAlex W7204140218
Open access: gold, a free copy (OpenAlex)
Status: code on request
Methods: Spectral & time-frequency, Statistics, Graphs
Keywords: oligodendrocyte progenitor cell, neonatal brain injury, ventricular-subventricular zone, remyelination, adherens junction, collective cell migration
Topic: Neurogenesis and neuroplasticity mechanisms (Developmental Neuroscience, Neuroscience), according to OpenAlex
Funding: Max Planck Institute; Kochi Medical School; Beckman Research Institute; Mutant Mouse Resource and Research Center; RIKEN; Japan Society for the Promotion of Science (20H03565, 21H05106, 23H02579, 23K27270, 24K18282, 25H01040, 25H02507); Core-to-Core Program (JPJSCCA20230007); JST FOREST (JPMJFR2146); Japan Agency for Medical Research and Development (24gm1210007); Nagoya City University (2401101); Valencian Council for Education, Culture, University and Employment (CIPROM/2023/053)
Citations: not cited yet (Europe PMC); 64 references in the paper
Research resources: Chicken anti-Neurofilament RRID:AB_10002431, Rabbit anti-MBP RRID:AB_1141521, RRID:AB_141607, Guinea pig anti-Dcx RRID:AB_1586992, RRID:AB_162542, Mouse anti-APC RRID:AB_2057371, Armenian Hamster anti-CD31 RRID:AB_2161039, Chicken anti-Nestin RRID:AB_2314882, RRID:AB_2339001, RRID:AB_2340363, Rabbit anti-NeuN RRID:AB_2532109, RRID:AB_2536183, RRID:AB_2687445, RRID:AB_2715515, RRID:AB_2827755, Rabbit anti-Olig2 RRID:AB_3697072, Mouse anti-N-Cadherin RRID:AB_398236, Mouse anti-S100β RRID:AB_477499, Mouse anti-βIII-tubulin RRID:AB_477590, pcDNA3.1-mCherry RRID:Addgene_128744, Mouse: Nestin-Cre RRID:IMSR_JAX:003771, Mouse: Rosa26R-tdTomato RRID:IMSR_JAX:007914, Mouse: Dcx-EGFP RRID:MMRRC_000244-MU

Abstract

Oligodendrocyte progenitor cells (OPCs) generated in the ventricular-subventricular zone (V-SVZ) migrate long distances to sites of brain injury to contribute to remyelination, but the mechanisms guiding their efficient recruitment remain unclear. Using a neonatal cortical injury model combined with live imaging and three-dimensional culture, we show that V-SVZ-derived OPCs migrate toward lesions by interacting with migrating neuroblasts that share the same route. Neuroblast contact significantly enhances OPC motility even in the absence of external scaffolds. High-resolution imaging reveals that these heterotypic interactions are associated with punctate adherens junctions that form and dissolve dynamically during migration. These findings uncover a previously unrecognized mechanism in which transient, dynamic adherens junctions support cooperative migration between neuronal and glial progenitors to facilitate efficient recruitment of OPCs to injured brain tissue.

Reproduced under the paper's license (CC BY), from the paper cited above.

Code

The paper says that its authors' code is available on request: it was not published with the paper, so there is nothing to verify.

The paper's code and data availability statement is in the Data section.

Tracing map

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Data

No dataset and no data link were found in the paper.

Data and code availability

• All data reported in this paper will be shared by the lead contact upon request. • This paper does not report original code. • Any additional information required to reanalyze the data reported in this paper is available from the lead contact upon request.

Reproduced under the paper's license (CC BY), from the paper cited above.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 2, 28 September 2026

  • Authors: added Kazuya Kuboyama (0000-0002-9878-1209); Naoko Kaneko (0000-0003-3121-7117); removed Kazuya Kuboyama; Naoko Kaneko

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 12 authors, 6 keywords, 11 funders, 64 references, 23 RRIDs.

Cite

This paper

Sobu, Y., Ito, N., Uy, E. W. K., Hashimoto, M., Kuboyama, K., Akazawa, C., Shibata, S., Takebayashi, H., Okano, H., Herranz-Pérez, V., Sawamoto, K., & Kaneko, N. (2026). Dynamic interactions with neuroblasts promote oligodendrocyte progenitor migration to injured cortex. iScience, 29(9), 117318. https://doi.org/10.1016/j.isci.2026.117318

BibTeX

@article{sobu2026dynamic,
author = {Sobu, Yuriko and Ito, Nodoka and Uy, Edward William Ko and Hashimoto, Mayaka and Kuboyama, Kazuya and Akazawa, Chihiro and Shibata, Shinsuke and Takebayashi, Hirohide and Okano, Hideyuki and Herranz-Pérez, Vicente and Sawamoto, Kazunobu and Kaneko, Naoko},
title = {{Dynamic interactions with neuroblasts promote oligodendrocyte progenitor migration to injured cortex}},
journal = {iScience},
year = {2026},
month = aug,
volume = {29},
number = {9},
pages = {117318},
publisher = {Elsevier},
issn = {2589-0042},
doi = {10.1016/j.isci.2026.117318},
url = {https://doi.org/10.1016/j.isci.2026.117318},
pmid = {42698966},
pmcid = {PMC13542502}
}

RIS

TY - JOUR
AU - Sobu, Yuriko
AU - Ito, Nodoka
AU - Uy, Edward William Ko
AU - Hashimoto, Mayaka
AU - Kuboyama, Kazuya
AU - Akazawa, Chihiro
AU - Shibata, Shinsuke
AU - Takebayashi, Hirohide
AU - Okano, Hideyuki
AU - Herranz-Pérez, Vicente
AU - Sawamoto, Kazunobu
AU - Kaneko, Naoko
TI - Dynamic interactions with neuroblasts promote oligodendrocyte progenitor migration to injured cortex
T2 - iScience
J2 - iScience
PY - 2026
DA - 2026/08/24
VL - 29
IS - 9
SP - 117318
SN - 2589-0042
PB - Elsevier
DO - 10.1016/j.isci.2026.117318
UR - https://doi.org/10.1016/j.isci.2026.117318
LA - en
ER -

CSL-JSON

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