OSCR

Photoreceptor outer segment disk rim curvature relies on a tetraspanin interaction web.

Overview

Authors: R Casey Boucher1, Michelle L Milstein1, Amirali Hossein2, Breyanna L Cavanaugh1, Alexander J Sodt2, Andrew H Beaven2, Andrew FX Goldberg1,3
ORCID iDs: R Casey Boucher, Amirali Hossein, Breyanna L Cavanaugh, Andrew FX Goldberg
  1. Eye Research Institute, Oakland University, Rochester, Michigan, USA
  2. Eunice Kennedy Shriver National Institutes of Child Health and Human Development, Intramural Research Program, National Institutes of Health, Bethesda, Maryland, USA
  3. Department of Foundational Medical Studies, Oakland University William Beaumont School of Medicine, Rochester, Michigan, USA
Institutions: Oakland University (United States); National Institutes of Health (United States); Eunice Kennedy Shriver National Institute of Child Health and Human Development (United States)
Journal: The Journal of biological chemistry, volume 302, issue 6, article 113136
Dates: received 16 December 2025; published online 11 May 2026; in print June 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1016/j.jbc.2026.113136 · PMID 42119983 · PMCID PMC13264345 · OpenAlex W7160862094
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: computational modeling (no new data) (modality), human (organism), cellular / molecular (subfield)
Keywords: cell biology, computational biology, disk rim, genetic disease, membrane biogenesis, membrane curvature, molecular dynamics, outer segment, photoreceptor, protein-protein interaction, retina, retinal degeneration, scaffold protein, tetraspanin, vision
MeSH: Peripherins*, Retinal Photoreceptor Cell Outer Segment*, Tetraspanins*, Animals, Humans, Molecular Dynamics Simulation (* major topic)
Topic: Cell Adhesion Molecules Research (Immunology and Allergy, Medicine), according to OpenAlex
Funding: National Institutes of Health; NEI NIH HHS (R01 EY025291); Eunice Kennedy Shriver National Institute of Child Health and Human Development (ZIA-HD008955); National Eye Institute (EY025291); Intramural NIH HHS (ZIA HD008955); Foundation Fighting Blindness Inc (TA-GT-0424-0883-OAK)
Citations: not cited yet (Europe PMC); 72 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

The paper links to its data, not to its authors' code: see the Data section.

Tracing map

A tracing map links a paper to the code its authors published: this paper has none, so it has no map.

Data

Datasets cited

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1016/j.jbc.2026.113136.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 2, 28 September 2026

  • Authors: added Breyanna L Cavanaugh (0009-0000-3217-7423); Andrew FX Goldberg (0000-0002-3964-5987); removed Breyanna L Cavanaugh; Andrew FX Goldberg

Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 7 authors, 15 keywords, 6 MeSH terms, 6 funders, 69 references.

Cite

This paper

Boucher, R. C., Milstein, M. L., Hossein, A., Cavanaugh, B. L., Sodt, A. J., Beaven, A. H., & Goldberg, A. F. (2026). Photoreceptor outer segment disk rim curvature relies on a tetraspanin interaction web. The Journal of biological chemistry, 302(6), 113136. https://doi.org/10.1016/j.jbc.2026.113136

BibTeX

@article{boucher2026photoreceptor,
author = {Boucher, R Casey and Milstein, Michelle L and Hossein, Amirali and Cavanaugh, Breyanna L and Sodt, Alexander J and Beaven, Andrew H and Goldberg, Andrew FX},
title = {{Photoreceptor outer segment disk rim curvature relies on a tetraspanin interaction web}},
journal = {The Journal of biological chemistry},
year = {2026},
month = may,
volume = {302},
number = {6},
pages = {113136},
publisher = {American Society for Biochemistry and Molecular Biology},
issn = {0021-9258},
doi = {10.1016/j.jbc.2026.113136},
url = {https://doi.org/10.1016/j.jbc.2026.113136},
pmid = {42119983},
pmcid = {PMC13264345}
}

RIS

TY - JOUR
AU - Boucher, R Casey
AU - Milstein, Michelle L
AU - Hossein, Amirali
AU - Cavanaugh, Breyanna L
AU - Sodt, Alexander J
AU - Beaven, Andrew H
AU - Goldberg, Andrew FX
TI - Photoreceptor outer segment disk rim curvature relies on a tetraspanin interaction web
T2 - The Journal of biological chemistry
J2 - J Biol Chem
PY - 2026
DA - 2026/05/11
VL - 302
IS - 6
SP - 113136
SN - 0021-9258
PB - American Society for Biochemistry and Molecular Biology
DO - 10.1016/j.jbc.2026.113136
UR - https://doi.org/10.1016/j.jbc.2026.113136
LA - en
ER -

CSL-JSON

{
"id": "10.1016/j.jbc.2026.113136",
"type": "article-journal",
"title": "Photoreceptor outer segment disk rim curvature relies on a tetraspanin interaction web",
"container-title": "The Journal of biological chemistry",
"author": [
{
"family": "Boucher",
"given": "R Casey"
},
{
"family": "Milstein",
"given": "Michelle L"
},
{
"family": "Hossein",
"given": "Amirali"
},
{
"family": "Cavanaugh",
"given": "Breyanna L"
},
{
"family": "Sodt",
"given": "Alexander J"
},
{
"family": "Beaven",
"given": "Andrew H"
},
{
"family": "Goldberg",
"given": "Andrew FX"
}
],
"container-title-short": "J Biol Chem",
"volume": "302",
"issue": "6",
"page": "113136",
"DOI": "10.1016/j.jbc.2026.113136",
"PMID": "42119983",
"PMCID": "PMC13264345",
"ISSN": "0021-9258",
"publisher": "American Society for Biochemistry and Molecular Biology",
"URL": "https://doi.org/10.1016/j.jbc.2026.113136",
"language": "en",
"issued": {
"date-parts": [
[
2026,
5,
11
]
]
}
}

Similar papers

The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.

[1] doi:10.1083/jcb.202509110
The missing link: Piccolino is essential for tethering synaptic vesicles to rod photoreceptor ribbons.
Journal: The Journal of cell biology
In common: cellular / molecular, 3 references
[2] doi:10.1038/s44321-026-00426-4
Systemic delivery of AAV-GFM1 corrects COXPD1 molecular alterations in Gfm1<sup>R671C/-</sup> mice.
Journal: EMBO molecular medicine
In common: cellular / molecular, 1 reference
[3] doi:10.21037/qims-2025-aw-2093 [code]
Outer retinal band segmentation in healthy subjects: comparative study between human grading and deep convolutional neural networks.
Journal: Quantitative imaging in medicine and surgery
In common: 1 reference
[4] doi:10.1021/acs.jcim.6c01299 [code]
Targeting BCL-2 through Deep Learning-Based Drug Repurposing: A Multimodal Approach Combining Diffusion-Based Generative Modeling, Neural Relational Inference, and In Vitro Validation.
Journal: Journal of chemical information and modeling
In common: computational modeling (no new data), cellular / molecular
[5] doi:10.1111/cbdd.70354
In Silico Drug Repositioning Identifies SYK Kinase Inhibitors as Potential Neuroprotective Agents for Ataxia-Telangiectasia.
Journal: Chemical biology & drug design
In common: computational modeling (no new data), cellular / molecular
[6] doi:10.1111/ejn.70604 [code]
The Role of the Glutamate-Glutamine Cycle in Synaptic Transmission During Ischemia and Recovery.
Journal: The European journal of neuroscience
In common: computational modeling (no new data), cellular / molecular
[7] doi:10.3389/fimmu.2026.1852083
Astrocyte-derived HMGB1 compromises the integrity of the blood-brain barrier through the CaM/CaMKII/AQP4 pathway and the protective function of trifluoperazine.
Journal: Frontiers in immunology
In common: computational modeling (no new data), cellular / molecular
[8] doi:10.1111/jnc.70470 [code]
Calcium Buffering in Astrocytes and Its Relevance for Experimental Data Interpretation and Computational Modeling.
Journal: Journal of neurochemistry
In common: computational modeling (no new data), cellular / molecular
[9] doi:10.1038/s41598-026-53415-5 [code]
Computational design and immunoinformatics validation of a T cell multi-epitope vaccine targeting glioblastoma stem cells.
Journal: Scientific reports
In common: computational modeling (no new data), cellular / molecular
[10] doi:10.1038/s41598-026-50523-0 [code]
Mechanistic multiscale modeling identifies putative natural tri-target candidates of MAO-B, LRRK2 and A₂A for Parkinson's disease.
Journal: Scientific reports
In common: computational modeling (no new data), cellular / molecular

Contribute

The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.

Sign in with ORCID to claim this paper as one of its authors, correct its record or validate its tracing map: when the paper's metadata lists your ORCID iD, you are recognized at once. Maintainers of its code: sign in with GitHub, then claim the repository on your account page.

Request its removal

To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).

Discussion, reproductions, activity

Discussion: questions and error reports about this paper and its code, from signed-in readers and its authors. It opens with sign-in.

Reproductions: reports from readers who ran the authors' code: what they reproduced, with which environment, commit and data. It opens with sign-in.

Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.