OSCR

Swine reporter model for preclinical evaluation and characterization of gene delivery vectors.

Overview

Authors: Jarryd M. Campbell1, Derek M. Korpela1, Hesong Han2,3, Sheng Zhao2,3, Dennis A. Webster1, Yen Anh H. Nguyen4, Nicholas Koes1, Robyn O. Aune1, Hinsoukpo Dagan1, Rebecca Milliken1, Jonathan K. Watts4,5, Niren Murthy2,3, Daniel F. Carlson1
ORCID iDs: Jarryd M. Campbell
  1. Recombinetics, New Brighton, MN 55112, USA
  2. Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94720, USA
  3. Department of Bioengineering, University of California, Berkeley, Berkeley, CA 94720, USA
  4. RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA
  5. Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Medical School, Worcester, MA 01605, USA
Institutions: Recombinetics (United States) (United States); Innovative Genomics Institute (United States); University of California, Berkeley (United States); University of Massachusetts Chan Medical School (United States)
Journal: Molecular therapy. Advances, volume 34, issue 2, article 201729
Dates: received 8 April 2025; accepted 31 March 2026; published online 3 April 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1016/j.omta.2026.201729 · PMID 42137606 · PMCID PMC13148913 · OpenAlex W7148746065
Open access: hybrid, a free copy (OpenAlex)
Status: code on request (how the code is found and verified)
Categories: cellular / molecular (subfield)
Methods: Evoked potentials, Physiology & signal measures
Keywords: animal models, AAV vectors, non-viral gene delivery, CRISPR-Cas9, gene therapy, routes of administration, swine, biodistribution, reporter, mRNA delivery
Topic: Virus-based gene therapy research (Genetics, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: Somatic Cell Genome Engineering Consortium; national institutes of health; Office of the Director (U24OD026641)
Citations: not cited yet (Europe PMC); 55 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

The paper says that its authors' code is available on request: it was not published with the paper, so there is nothing to verify.

The paper's code and data availability statement is in the Data section.

Tracing map

A tracing map links a paper to the code its authors published: this paper has none (its code is available on request), so it has no map.

Data

No dataset and no data link were found in the paper.

Code and data availability statement

The paper has a code and data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • it says that the data are available on request
  • it says that the code is available on request

Read it in the paper: doi.org/10.1016/j.omta.2026.201729.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 2, 28 September 2026

  • Authors: added Jarryd M. Campbell (0009-0006-5591-2260); removed Jarryd M. Campbell

Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 13 authors, 10 keywords, 3 funders, 54 references.

Cite

This paper

Campbell, J. M., Korpela, D. M., Han, H., Zhao, S., Webster, D. A., Nguyen, Y. A. H., Koes, N., Aune, R. O., Dagan, H., Milliken, R., Watts, J. K., Murthy, N., & Carlson, D. F. (2026). Swine reporter model for preclinical evaluation and characterization of gene delivery vectors. Molecular therapy. Advances, 34(2), 201729. https://doi.org/10.1016/j.omta.2026.201729

BibTeX

@article{campbell2026swine,
author = {Campbell, Jarryd M. and Korpela, Derek M. and Han, Hesong and Zhao, Sheng and Webster, Dennis A. and Nguyen, Yen Anh H. and Koes, Nicholas and Aune, Robyn O. and Dagan, Hinsoukpo and Milliken, Rebecca and Watts, Jonathan K. and Murthy, Niren and Carlson, Daniel F.},
title = {{Swine reporter model for preclinical evaluation and characterization of gene delivery vectors}},
journal = {Molecular therapy. Advances},
year = {2026},
month = apr,
volume = {34},
number = {2},
pages = {201729},
publisher = {American Society of Gene \& Cell Therapy},
issn = {3117-387X},
doi = {10.1016/j.omta.2026.201729},
url = {https://doi.org/10.1016/j.omta.2026.201729},
pmid = {42137606},
pmcid = {PMC13148913}
}

RIS

TY - JOUR
AU - Campbell, Jarryd M.
AU - Korpela, Derek M.
AU - Han, Hesong
AU - Zhao, Sheng
AU - Webster, Dennis A.
AU - Nguyen, Yen Anh H.
AU - Koes, Nicholas
AU - Aune, Robyn O.
AU - Dagan, Hinsoukpo
AU - Milliken, Rebecca
AU - Watts, Jonathan K.
AU - Murthy, Niren
AU - Carlson, Daniel F.
TI - Swine reporter model for preclinical evaluation and characterization of gene delivery vectors
T2 - Molecular therapy. Advances
J2 - Mol Ther Adv
PY - 2026
DA - 2026/04/03
VL - 34
IS - 2
SP - 201729
SN - 3117-387X
PB - American Society of Gene & Cell Therapy
DO - 10.1016/j.omta.2026.201729
UR - https://doi.org/10.1016/j.omta.2026.201729
LA - en
ER -

CSL-JSON

{
"id": "10.1016/j.omta.2026.201729",
"type": "article-journal",
"title": "Swine reporter model for preclinical evaluation and characterization of gene delivery vectors",
"container-title": "Molecular therapy. Advances",
"author": [
{
"family": "Campbell",
"given": "Jarryd M."
},
{
"family": "Korpela",
"given": "Derek M."
},
{
"family": "Han",
"given": "Hesong"
},
{
"family": "Zhao",
"given": "Sheng"
},
{
"family": "Webster",
"given": "Dennis A."
},
{
"family": "Nguyen",
"given": "Yen Anh H."
},
{
"family": "Koes",
"given": "Nicholas"
},
{
"family": "Aune",
"given": "Robyn O."
},
{
"family": "Dagan",
"given": "Hinsoukpo"
},
{
"family": "Milliken",
"given": "Rebecca"
},
{
"family": "Watts",
"given": "Jonathan K."
},
{
"family": "Murthy",
"given": "Niren"
},
{
"family": "Carlson",
"given": "Daniel F."
}
],
"container-title-short": "Mol Ther Adv",
"volume": "34",
"issue": "2",
"page": "201729",
"DOI": "10.1016/j.omta.2026.201729",
"PMID": "42137606",
"PMCID": "PMC13148913",
"ISSN": "3117-387X",
"publisher": "American Society of Gene & Cell Therapy",
"URL": "https://doi.org/10.1016/j.omta.2026.201729",
"language": "en",
"issued": {
"date-parts": [
[
2026,
4,
3
]
]
}
}

Similar papers

The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.

[1] doi:10.1016/j.ymthe.2025.03.057
Current trends in gene therapy to treat inherited disorders of the brain.
Journal: Molecular therapy : the journal of the American Society of Gene Therapy
In common: 6 references
[2] doi:10.1038/s44321-026-00426-4
Systemic delivery of AAV-GFM1 corrects COXPD1 molecular alterations in Gfm1<sup>R671C/-</sup> mice.
Journal: EMBO molecular medicine
In common: cellular / molecular, 5 references
[3] doi:10.1038/s41598-026-38039-z [code]
Comparison of AAV9-driven motor neuron transduction following different CNS-directed delivery methods in mice.
Journal: Scientific reports
In common: 5 references
[4] doi:10.1126/science.adg6518 [code]
Base editing rescue of spinal muscular atrophy in cells and in mice.
Journal: Science (New York, N.Y.)
In common: cellular / molecular, 5 references
[5] doi:10.1038/s41467-024-48974-y
Engineering viral vectors for acoustically targeted gene delivery.
Journal: Nature communications
In common: cellular / molecular, 4 references
[6] doi:10.3390/ijms262311645 [code]
An AAV-Based Therapy Approach for Neurological Phenotypes of X-Linked Adrenoleukodystrophy.
Journal: International journal of molecular sciences
In common: 4 references
[7] doi:10.1016/j.medj.2022.11.002 [code]
Systemic administration of novel engineered AAV capsids facilitates enhanced transgene expression in the macaque CNS.
Journal: Med (New York, N.Y.)
In common: 4 references
[8] doi:10.1021/acsnano.4c15013 [code]
AI-Validated Brain Targeted mRNA Lipid Nanoparticles with Neuronal Tropism.
Journal: ACS nano
In common: cellular / molecular, 3 references
[9] doi:10.1073/pnas.2506257122
TIGER: A tdTomato in vivo genome-editing reporter mouse for investigating precision-editor delivery approaches.
Journal: Proceedings of the National Academy of Sciences of the United States of America
In common: cellular / molecular, 3 references
[10] doi:10.1038/s41467-026-73545-8
Long-term comparative analysis of AAV9-mediated gene replacement therapies for spinal muscular atrophy in mice.
Journal: Nature communications
In common: 3 references

Contribute

The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.

Sign in with ORCID to claim this paper as one of its authors, correct its record or validate its tracing map: when the paper's metadata lists your ORCID iD, you are recognized at once. Maintainers of its code: sign in with GitHub, then claim the repository on your account page.

Request its removal

To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).

Discussion, reproductions, activity

Discussion: code errors and mismatches between the code and the paper about this paper and its code, from readers and its authors, beside the paper and its tracing map.

Reproductions: reports from readers who ran the authors' code and did not get the paper's result, what they ran, with which environment, commit and data.

Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.