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Selective Ca<sub>v</sub>1.3 inhibition promotes survival of transplanted dopaminergic neurons via the CaMKII-p65-p53 pathway.

Overview

Authors: Qingyuan Tang1,2, Jing Sun2, Jun Xue3, Chen Qiu2, Tian Wang2, Tatyana Matveeva2, Yifan Wu3, Xiaoying Li1, Tianlin Cheng4, Hyemyung Seo5, Mingtao Li1, Shanshan Ma1, Jeffrey S Schweitzer2, Bin Song2
ORCID iDs: Chen Qiu, Tian Wang, Bin Song
  1. Guangdong Provincial Key Laboratory of Brain Function and Disease, Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China
  2. George A. “Doc” Lopez, MD Laboratory for Regenerative Cell Therapy, Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
  3. Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China
  4. Institutes for Translational Brain Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai 200032, China
  5. Department of Molecular Medicine, School of Bio-Pharmaceutical Convergence, Institute for Precision Therapeutics, Hanyang University, Ansan 15588, South Korea
Institutions: Sun Yat-sen University (China); Massachusetts General Hospital (United States); Harvard University (United States); Fudan University (China); Huashan Hospital (China); Frontiers Center for Brain Science of the Ministry of Education (China); Hanyang University (South Korea)
Journal: Stem cell reports, volume 21, issue 4, article 102830
Dates: received 26 August 2025; accepted 3 February 2026; published online 5 March 2026; in print April 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1016/j.stemcr.2026.102830 · PMID 41791389 · PMCID PMC13083790 · OpenAlex W7133615522
Open access: gold, a free copy (OpenAlex)
Status: code on request
Categories: human (organism), mouse (organism), Parkinson's (population)
Methods: Statistics
Keywords: Parkinson's disease, cell therapy, hPSCs, dopaminergic neurons, graft survival, Cav1.3, CaMKII-p65-p53 pathway
MeSH: Calcium Channel Blockers*, Calcium Channels, L-Type*, Calcium-Calmodulin-Dependent Protein Kinase Type 2*, Dopaminergic Neurons*, Signal Transduction*, Tumor Suppressor Protein p53*, Animals, Apoptosis, Cell Survival, Human Embryonic Stem Cells, Humans, Mesencephalon, Mice, Parkinson Disease (* major topic)
Topic: Cancer-related Molecular Pathways (Oncology, Medicine), according to OpenAlex
Funding: Fudan University; National Key Research and Development Program of China (2022YFE0139000); Sun Yat-Sen University; National Research Foundation of Korea (RS-2022-NR066718); Hanyang University
Citations: not cited yet (Europe PMC); 48 references in the paper

Abstract

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Code

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Data

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Code and data availability statement

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Read it in the paper: doi.org/10.1016/j.stemcr.2026.102830.

Versions

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Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 14 authors, 7 keywords, 14 MeSH terms, 5 funders, 48 references.

Cite

This paper

Tang, Q., Sun, J., Xue, J., Qiu, C., Wang, T., Matveeva, T., Wu, Y., Li, X., Cheng, T., Seo, H., Li, M., Ma, S., Schweitzer, J. S., & Song, B. (2026). Selective Ca<sub>v</sub>1.3 inhibition promotes survival of transplanted dopaminergic neurons via the CaMKII-p65-p53 pathway. Stem cell reports, 21(4), 102830. https://doi.org/10.1016/j.stemcr.2026.102830

BibTeX

@article{tang2026selective,
author = {Tang, Qingyuan and Sun, Jing and Xue, Jun and Qiu, Chen and Wang, Tian and Matveeva, Tatyana and Wu, Yifan and Li, Xiaoying and Cheng, Tianlin and Seo, Hyemyung and Li, Mingtao and Ma, Shanshan and Schweitzer, Jeffrey S and Song, Bin},
title = {{Selective Ca\<sub\>v\</sub\>1.3 inhibition promotes survival of transplanted dopaminergic neurons via the CaMKII-p65-p53 pathway}},
journal = {Stem cell reports},
year = {2026},
month = mar,
volume = {21},
number = {4},
pages = {102830},
publisher = {Elsevier},
issn = {2213-6711},
doi = {10.1016/j.stemcr.2026.102830},
url = {https://doi.org/10.1016/j.stemcr.2026.102830},
pmid = {41791389},
pmcid = {PMC13083790}
}

RIS

TY - JOUR
AU - Tang, Qingyuan
AU - Sun, Jing
AU - Xue, Jun
AU - Qiu, Chen
AU - Wang, Tian
AU - Matveeva, Tatyana
AU - Wu, Yifan
AU - Li, Xiaoying
AU - Cheng, Tianlin
AU - Seo, Hyemyung
AU - Li, Mingtao
AU - Ma, Shanshan
AU - Schweitzer, Jeffrey S
AU - Song, Bin
TI - Selective Ca<sub>v</sub>1.3 inhibition promotes survival of transplanted dopaminergic neurons via the CaMKII-p65-p53 pathway
T2 - Stem cell reports
J2 - Stem Cell Reports
PY - 2026
DA - 2026/03/05
VL - 21
IS - 4
SP - 102830
SN - 2213-6711
PB - Elsevier
DO - 10.1016/j.stemcr.2026.102830
UR - https://doi.org/10.1016/j.stemcr.2026.102830
LA - en
ER -

CSL-JSON

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