Mettl3 promotes reprogramming and axonogenesis of induced retinal ganglion cells.

Overview

Authors: Ke Zhang¹, Huilin Liang¹, Shuyi Chen¹

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China

Institutions: State Key Laboratory of Ophthalmology; Zhongshan Ophthalmic Center, Sun Yat-sen University; Sun Yat-sen University (China)

Journal: Stem cell reports, volume 21, issue 4, article 102851

Dates: received 28 August 2025; accepted 6 February 2026; published online 5 March 2026; in print April 2026

Type: Research article · Language: English

License: CC BY-NC-ND

Identifiers: DOI 10.1016/j.stemcr.2026.102851 · PMID 41791385 · PMCID PMC13083793 · OpenAlex W7133922635

Open access: gold, a free copy (OpenAlex)

Status: data only

Categories: mouse (organism), cellular / molecular (subfield)

Methods: Statistics, Evoked potentials

Keywords: Mettl3, m⁶A modification, neural fate reprogramming, axonogenesis, induced retinal ganglion cells, somatic cell reprogramming

MeSH: Axons*, Cellular Reprogramming*, Methyltransferases*, Neurogenesis*, Retinal Ganglion Cells*, Adenosine, Animals, Cell Differentiation, Epitranscriptome, Epitranscriptomics, Mice, RNA Methylation (* major topic)

Topic: Neurofibromatosis and Schwannoma Cases (Neurology, Medicine), according to OpenAlex

Funding: Department of Science and Technology of Guangdong Province (2024A1515012938); National Natural Science Foundation of China (32470848)

Citations: cited by 2 papers (Europe PMC); 50 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Datasets cited

geo:GSE305553, at NCBI GEO; found in “Data and code availability”

Code and data availability statement

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it points to a dataset: NCBI GEO GSE305553

Read it in the paper: doi.org/10.1016/j.stemcr.2026.102851.

Versions

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Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 3 authors, 6 keywords, 12 MeSH terms, 2 funders, 50 references.

Cite

This paper

Zhang, K., Liang, H., & Chen, S. (2026). Mettl3 promotes reprogramming and axonogenesis of induced retinal ganglion cells. Stem cell reports, 21(4), 102851. https://doi.org/10.1016/j.stemcr.2026.102851

BibTeX

@article{zhang2026mettl3, author = {Zhang, Ke and Liang, Huilin and Chen, Shuyi}, title = {{Mettl3 promotes reprogramming and axonogenesis of induced retinal ganglion cells}}, journal = {Stem cell reports}, year = {2026}, month = mar, volume = {21}, number = {4}, pages = {102851}, publisher = {Elsevier}, issn = {2213-6711}, doi = {10.1016/j.stemcr.2026.102851}, url = {https://doi.org/10.1016/j.stemcr.2026.102851}, pmid = {41791385}, pmcid = {PMC13083793} }

RIS

TY - JOUR AU - Zhang, Ke AU - Liang, Huilin AU - Chen, Shuyi TI - Mettl3 promotes reprogramming and axonogenesis of induced retinal ganglion cells T2 - Stem cell reports J2 - Stem Cell Reports PY - 2026 DA - 2026/03/05 VL - 21 IS - 4 SP - 102851 SN - 2213-6711 PB - Elsevier DO - 10.1016/j.stemcr.2026.102851 UR - https://doi.org/10.1016/j.stemcr.2026.102851 LA - en ER -

CSL-JSON

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