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The regenerative role of neural crest stem cells in physical stimuli-enhanced peripheral nerve repair.

Overview

Authors: Youyi Tai1, Lu Jin1, Thamidul Islam Tonmoy1, B. Hyle Park1, Jin Nam1
ORCID iDs: Jin Nam
  1. Department of Bioengineering, University of California, Riverside, Riverside, CA 92521, USA
Institutions: University of California, Riverside (United States)
Journal: Stem cell reports, volume 21, issue 4, article 102861
Dates: received 1 July 2025; accepted 24 February 2026; published online 26 March 2026; in print April 2026
Type: Brief report · Language: English
License: CC BY
Identifiers: DOI 10.1016/j.stemcr.2026.102861 · PMID 41895271 · PMCID PMC13083801 · OpenAlex W7140703741
Open access: gold, a free copy (OpenAlex)
Status: code on request (how the code is found and verified)
Categories: developmental (subfield)
Methods: Statistics
Keywords: neural crest stem cell, mechano-electrical stimulation, differentiation, peripheral nerve regeneration, SMAD, neuregulin 1, NFATc3
MeSH: Nerve Regeneration*, Neural Crest*, Neural Stem Cells*, Peripheral Nerve Injuries*, Animals, Bone Morphogenetic Proteins, Cell Differentiation, Electric Stimulation, Neuregulin-1, Neurons, Schwann Cells, Signal Transduction, Smad Proteins (* major topic)
Topic: Nerve injury and regeneration (Cellular and Molecular Neuroscience, Neuroscience), according to OpenAlex
Funding: National Science Foundation; California Institute for Regenerative Medicine
Citations: not cited yet (Europe PMC); 30 references in the paper

Abstract

Neural crest stem cells (NCSCs), capable of differentiating into neurons and Schwann cells, are essential for peripheral nerve regeneration. This study investigates the role of endogenous NCSC-like cells in mechano-electrical stimulation (MES)-enhanced peripheral nerve repair. In a critical-sized nerve injury model, MES leads to complete nerve reconnection, accompanied by a significant increase in NCSC-like cells at the injury sites. In vitro, MES promotes the simultaneous differentiation of NCSC-like cells into neurons and Schwann cells, with elevated neuregulin 1 (NRG1) expression, a key factor in Schwann cell development. Mechanistically, MES activates BMP/Smad signaling, driving neuronal differentiation and subsequent NRG1 secretion, which in turn promotes Schwann cell maturation through the ErBB/NFAT pathway. These findings demonstrate that MES enhances peripheral nerve regeneration by activating and directing stem cell differentiation, supporting a novel therapeutic approach that utilizes physical stimulation for stem cell modulation for nerve repair.

Reproduced under the paper's license (CC BY), from the paper cited above.

Code

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The paper's code and data availability statement is in the Data section.

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Reproduced under the paper's license (CC BY), from the paper cited above.

Versions

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Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 5 authors, 6 keywords, 13 MeSH terms, 2 funders, 30 references.

Cite

This paper

Tai, Y., Jin, L., Tonmoy, T. I., Park, B. H., & Nam, J. (2026). The regenerative role of neural crest stem cells in physical stimuli-enhanced peripheral nerve repair. Stem cell reports, 21(4), 102861. https://doi.org/10.1016/j.stemcr.2026.102861

BibTeX

@article{tai2026regenerative,
author = {Tai, Youyi and Jin, Lu and Tonmoy, Thamidul Islam and Park, B. Hyle and Nam, Jin},
title = {{The regenerative role of neural crest stem cells in physical stimuli-enhanced peripheral nerve repair}},
journal = {Stem cell reports},
year = {2026},
month = mar,
volume = {21},
number = {4},
pages = {102861},
publisher = {Elsevier},
issn = {2213-6711},
doi = {10.1016/j.stemcr.2026.102861},
url = {https://doi.org/10.1016/j.stemcr.2026.102861},
pmid = {41895271},
pmcid = {PMC13083801}
}

RIS

TY - JOUR
AU - Tai, Youyi
AU - Jin, Lu
AU - Tonmoy, Thamidul Islam
AU - Park, B. Hyle
AU - Nam, Jin
TI - The regenerative role of neural crest stem cells in physical stimuli-enhanced peripheral nerve repair
T2 - Stem cell reports
J2 - Stem Cell Reports
PY - 2026
DA - 2026/03/26
VL - 21
IS - 4
SP - 102861
SN - 2213-6711
PB - Elsevier
DO - 10.1016/j.stemcr.2026.102861
UR - https://doi.org/10.1016/j.stemcr.2026.102861
LA - en
ER -

CSL-JSON

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