Multisensory integration in peripersonal space indexes consciousness states in sleep and disorders of consciousness.
Overview
- MySpace Lab, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
- Translational Neural Engineering Lab, Neuro-X Institute, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
- Sleep and Dreams Group, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands
- Acute Neurorehabilitation Unit, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
- Center for Investigation and Research on Sleep, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
- MANIBUS Lab, Psychology Department, University of Turin, Turin, Italy
- Department of Medical Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
- Laboratoire de Recherche en Neuroimagerie (LREN), Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
- Department of Neuroscience, University of Minnesota, Minneapolis, MN, USA
- Department of Electrical, Electronic, and Information Engineering “Guglielmo Marconi”, University of Bologna, Cesena Campus, Cesena, Italy
Abstract
Reliably detecting consciousness in unresponsive patients remains an urgent ethical and clinical challenge, as no behavior-independent marker is currently accepted in clinical practice. We characterize consciousness as linked to a representation of the embodied subject of experience, mediated by multisensory integration within the peripersonal space (PPS) system. We test whether a neural marker of PPS representation could detect consciousness and predict clinical outcome in disorders of consciousness (DoC) patients. Using high-density electroencephalography (EEG) during a task-free audiotactile task, we derive a PPS index based on high-beta oscillations. In healthy participants, the PPS index is present during wakefulness and dreaming, but absent in dreamless sleep. In 72 DoC patients, the PPS index correlates with behavioral measures of consciousness and predicts recovery at discharge. The index is associated with forebrain mesocircuit integrity. These findings highlight a bedside-compatible electrophysiological marker with potential clinical utility for detecting covert consciousness and predicting outcomes in non-responsive patients.
Reproduced under the paper's license (CC BY), from the paper cited above.
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• The EEG and questionnaire/
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Versions
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Version 1, 30 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 20 authors, 7 keywords, 12 MeSH terms, 2 funders, 105 references, 3 RRIDs.
Cite
This paper
Bertoni, T., Ricci, G., Jöhr, J., Donno, B., Cataldi, J., Fellrath, J., Stephan, A., Foglia, C., Lecci, S., Dauvin, F., Lopes Da Silva, M., Galigani, M., Pozeg, P., Dunet, V., De Lucia, M., Noel, J.-P., Magosso, E., Diserens, K., Siclari, F., & Serino, A. (2026). Multisensory integration in peripersonal space indexes consciousness states in sleep and disorders of consciousness. Cell reports. Medicine, 7(4), 102705. https://
BibTeX
@article{bertoni2026mult
author = {Bertoni, Tommaso and Ricci, Giulia and Jöhr, Jane and Donno, Brunella and Cataldi, Jacinthe and Fellrath, Julia and Stephan, Aurelie and Foglia, Carolina and Lecci, Sandro and Dauvin, Floriane and Lopes Da Silva, Marina and Galigani, Mattia and Pozeg, Polona and Dunet, Vincent and De Lucia, Marzia and Noel, Jean-Paul and Magosso, Elisa and Diserens, Karin and Siclari, Francesca and Serino, Andrea},
title = {{Multisensory integration in peripersonal space indexes consciousness states in sleep and disorders of consciousness}},
journal = {Cell reports. Medicine},
year = {2026},
month = mar,
volume = {7},
number = {4},
pages = {102705},
publisher = {Elsevier},
issn = {2666-3791},
doi = {10.1016/
url = {https://
pmid = {41923621},
pmcid = {PMC13130652}
}
RIS
TY - JOUR
AU - Bertoni, Tommaso
AU - Ricci, Giulia
AU - Jöhr, Jane
AU - Donno, Brunella
AU - Cataldi, Jacinthe
AU - Fellrath, Julia
AU - Stephan, Aurelie
AU - Foglia, Carolina
AU - Lecci, Sandro
AU - Dauvin, Floriane
AU - Lopes Da Silva, Marina
AU - Galigani, Mattia
AU - Pozeg, Polona
AU - Dunet, Vincent
AU - De Lucia, Marzia
AU - Noel, Jean-Paul
AU - Magosso, Elisa
AU - Diserens, Karin
AU - Siclari, Francesca
AU - Serino, Andrea
TI - Multisensory integration in peripersonal space indexes consciousness states in sleep and disorders of consciousness
T2 - Cell reports. Medicine
J2 - Cell Rep Med
PY - 2026
DA - 2026/
VL - 7
IS - 4
SP - 102705
SN - 2666-3791
PB - Elsevier
DO - 10.1016/
UR - https://
LA - en
ER -
CSL-JSON
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