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CSNK2B gene replacement rescues autism-related phenotypes and establishes translational EEG biomarkers.

Overview

Authors: Chaodong Ding1, Xiaqing Wang1, Yiting Yuan1, Yuefang Zhang1, Yixin Hu1, Changhe Wang1, Ailian Du1, Zilong Qiu1,2
ORCID iDs: Chaodong Ding
  1. Department of Neurology, Songjiang Research Institute, Shanghai Key Laboratory of Emotions and Affective Disorders, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
  2. MOE-Shanghai Key Laboratory of Children’s Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Institutions: Shanghai Jiao Tong University (China); XinHua Hospital (China)
Journal: Cell reports. Medicine, volume 7, issue 6, article 102832
Dates: received 21 October 2025; accepted 28 April 2026; published online 26 May 2026; in print June 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1016/j.xcrm.2026.102832 · PMID 42190665 · PMCID PMC13293933 · OpenAlex W7162424872
Open access: gold, a free copy (OpenAlex)
Status: code on request
Categories: EEG (modality), human (organism), mouse (organism), epilepsy (population), autism (population)
Methods: Spectral & time-frequency, Preprocessing, Connectivity, Statistics, Evoked potentials, fMRI & imaging, Machine learning
Keywords: CSNK2B mutations, autism, epilepsy, Csnk2b+/− mice, gene therapy
MeSH: Autistic Disorder*, Casein Kinase II*, Electroencephalography*, Animals, Biomarkers, Brain, Disease Models, Animal, Female, Genetic Therapy, Haploinsufficiency, Humans, Male, Mice, Phenotype, Seizures (* major topic)
Topic: Autism Spectrum Disorder Research (Cognitive Neuroscience, Neuroscience), according to OpenAlex
Funding: National Natural Science Foundation of China (82430046, 82301334); National Science and Technology Major Project; Shanghai Municipal Health Commission (2024ZZ1007); National Major Science and Technology Projects of China (2025ZD0214700)
Citations: not cited yet (Europe PMC); 48 references in the paper
Research resources: Goat anti-rabbit IgG - H&L (HRP) RRID:AB_10679369, Rabbit polyclonal anti-NeuN RRID:AB_10807945, Rabbit monoclonal anti-Csnk2b RRID:AB_1523263, Donkey anti-mouse, Alexa Fluor 647 RRID:AB_162542, Donkey anti-rabbit, Alexa Fluor 555 RRID:AB_162543, Rat monoclonal anti-Ctip2 RRID:AB_2064130, Rabbit polyclonal anti-β-Tubulin RRID:AB_2210370, Rabbit monoclonal anti-Parvalbumin RRID:AB_2313773, Donkey anti-rabbit, Alexa Fluor 488 RRID:AB_2535792, Donkey anti-rabbit, Alexa Fluor 647 RRID:AB_2536183, DAPI RRID:AB_2629482, Donkey anti-Rat, Alexa Fluor 647 RRID:AB_2893138, Rabbit monoclonal anti-Tbr1 RRID:AB_2936859, Mouse monoclonal anti-Somatostatin RRID:AB_831726, EthoVision XT RRID:SCR_000441, GraphPad Prism RRID:SCR_002798, ImageJ RRID:SCR_003070

Abstract

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Code

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Data

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Code and data availability statement

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Read it in the paper: doi.org/10.1016/j.xcrm.2026.102832.

Versions

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Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 8 authors, 5 keywords, 15 MeSH terms, 4 funders, 48 references, 17 RRIDs.

Cite

This paper

Ding, C., Wang, X., Yuan, Y., Zhang, Y., Hu, Y., Wang, C., Du, A., & Qiu, Z. (2026). CSNK2B gene replacement rescues autism-related phenotypes and establishes translational EEG biomarkers. Cell reports. Medicine, 7(6), 102832. https://doi.org/10.1016/j.xcrm.2026.102832

BibTeX

@article{ding2026csnk2b,
author = {Ding, Chaodong and Wang, Xiaqing and Yuan, Yiting and Zhang, Yuefang and Hu, Yixin and Wang, Changhe and Du, Ailian and Qiu, Zilong},
title = {{CSNK2B gene replacement rescues autism-related phenotypes and establishes translational EEG biomarkers}},
journal = {Cell reports. Medicine},
year = {2026},
month = may,
volume = {7},
number = {6},
pages = {102832},
publisher = {Elsevier},
issn = {2666-3791},
doi = {10.1016/j.xcrm.2026.102832},
url = {https://doi.org/10.1016/j.xcrm.2026.102832},
pmid = {42190665},
pmcid = {PMC13293933}
}

RIS

TY - JOUR
AU - Ding, Chaodong
AU - Wang, Xiaqing
AU - Yuan, Yiting
AU - Zhang, Yuefang
AU - Hu, Yixin
AU - Wang, Changhe
AU - Du, Ailian
AU - Qiu, Zilong
TI - CSNK2B gene replacement rescues autism-related phenotypes and establishes translational EEG biomarkers
T2 - Cell reports. Medicine
J2 - Cell Rep Med
PY - 2026
DA - 2026/05/26
VL - 7
IS - 6
SP - 102832
SN - 2666-3791
PB - Elsevier
DO - 10.1016/j.xcrm.2026.102832
UR - https://doi.org/10.1016/j.xcrm.2026.102832
LA - en
ER -

CSL-JSON

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