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A biomimetic hybrid membrane vesicle nanoplatform attenuates tendinopathy through neuroinflammation modulation and tendon regeneration.

Overview

Authors: Dongxu Li1, Wei Huang1, Feifei Ni2, Wenbo Yang1, Xiao Lv1, Fashuai Wu1, Fei Gao1, Yu He1, Tingfang Sun1, Wei Yu1, Zekang Xiong1, Chunqing Meng1, Hong Wang1, Yizhong Peng1
  1. Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
  2. Department of Orthopedics, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China
Journal: Cell reports. Medicine, volume 7, issue 8, article 102937
Dates: received 17 October 2025; accepted 26 June 2026; published online 23 July 2026; in print August 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1016/j.xcrm.2026.102937 · PMID 42492519 · PMCID PMC13522776 · OpenAlex W7170135687
Open access: gold, a free copy (OpenAlex)
Status: code on request
Categories: human (organism), cellular / molecular (subfield)
Methods: Statistics
Keywords: tendinopathy, hybrid membrane vesicle, decellularized tendon matrix, tendon regeneration
MeSH: Biomimetic Materials*, Biomimetics*, Neuroinflammatory Diseases*, Regeneration*, Tendinopathy*, Tendons*, Animals, Cell Differentiation, Humans, Inflammation, Macrophages, Male, Sensory Receptor Cells, Stem Cells (* major topic)
Topic: Tendon Structure and Treatment (Orthopedics and Sports Medicine, Medicine), according to OpenAlex
Funding: Hubei Province Natural Science Foundation; National Natural Science Foundation of China
Citations: not cited yet (Europe PMC); 56 references in the paper
Research resources: Rabbit Polyclonal anti-CD206 RRID:AB_10597232, Rabbit Polyclonal anti-TAC1 RRID:AB_10898173, Rabbit Polyclonal anti-CD14 RRID:AB_2074048, Rabbit Polyclonal anti-F4/80 RRID:AB_2716814, Rabbit Polyclonal anti-c-Fos RRID:AB_2764354, Rabbit Polyclonal anti-CGRP RRID:AB_2766323, Mouse Monoclonal anti-GAPDH RRID:AB_2769570, Rabbit Polyclonal anti-TRPV1 RRID:AB_2772734, Rabbit Polyclonal anti-p-JAK2 RRID:AB_2834455, Rabbit Polyclonal anti-Collagen III RRID:AB_2837941, Rabbit Polyclonal anti-p21 RRID:AB_2838386, Rabbit Polyclonal anti-MMP3 RRID:AB_2861563, Rabbit Polyclonal anti-p16 RRID:AB_2861619, Rabbit Polyclonal anti-Na+/K+-ATPase RRID:AB_2861628, Rabbit Polyclonal anti-Neurofilament RRID:AB_2862576, Rabbit Polyclonal anti-TrkA RRID:AB_2863195, Rabbit Polyclonal anti-p-STAT3 RRID:AB_2863810, Mouse Monoclonal anti-CD90 RRID:AB_2882112, Mouse Monoclonal anti-TNC RRID:AB_2882900, Rabbit Polyclonal anti-CD86 RRID:AB_3086387, Rabbit Polyclonal anti-TNMD RRID:AB_3103100, Rabbit Recombinant anti-CD45 RRID:AB_3672366, Mouse Monoclonal anti-STAT3 RRID:AB_3711487, Rabbit Polyclonal anti-JAK2 RRID:AB_3712030, Rabbit Polyclonal anti-COL1A2 RRID:AB_3712537, Rabbit Recombinant anti-CD34 RRID:AB_3746394, Rabbit Recombinant anti-CD90 RRID:AB_3749375, Rabbit Recombinant anti-CD44 RRID:AB_3749551, Rabbit Polyclonal anti-p16 RRID:AB_3751506, Mouse Monoclonal anti-CD68 RRID:AB_627157

Abstract

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Code

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Data

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Code and data availability statement

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Read it in the paper: doi.org/10.1016/j.xcrm.2026.102937.

Versions

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 14 authors, 4 keywords, 14 MeSH terms, 2 funders, 56 references, 30 RRIDs.

Cite

This paper

Li, D., Huang, W., Ni, F., Yang, W., Lv, X., Wu, F., Gao, F., He, Y., Sun, T., Yu, W., Xiong, Z., Meng, C., Wang, H., & Peng, Y. (2026). A biomimetic hybrid membrane vesicle nanoplatform attenuates tendinopathy through neuroinflammation modulation and tendon regeneration. Cell reports. Medicine, 7(8), 102937. https://doi.org/10.1016/j.xcrm.2026.102937

BibTeX

@article{li2026biomimetic,
author = {Li, Dongxu and Huang, Wei and Ni, Feifei and Yang, Wenbo and Lv, Xiao and Wu, Fashuai and Gao, Fei and He, Yu and Sun, Tingfang and Yu, Wei and Xiong, Zekang and Meng, Chunqing and Wang, Hong and Peng, Yizhong},
title = {{A biomimetic hybrid membrane vesicle nanoplatform attenuates tendinopathy through neuroinflammation modulation and tendon regeneration}},
journal = {Cell reports. Medicine},
year = {2026},
month = jul,
volume = {7},
number = {8},
pages = {102937},
publisher = {Elsevier},
issn = {2666-3791},
doi = {10.1016/j.xcrm.2026.102937},
url = {https://doi.org/10.1016/j.xcrm.2026.102937},
pmid = {42492519},
pmcid = {PMC13522776}
}

RIS

TY - JOUR
AU - Li, Dongxu
AU - Huang, Wei
AU - Ni, Feifei
AU - Yang, Wenbo
AU - Lv, Xiao
AU - Wu, Fashuai
AU - Gao, Fei
AU - He, Yu
AU - Sun, Tingfang
AU - Yu, Wei
AU - Xiong, Zekang
AU - Meng, Chunqing
AU - Wang, Hong
AU - Peng, Yizhong
TI - A biomimetic hybrid membrane vesicle nanoplatform attenuates tendinopathy through neuroinflammation modulation and tendon regeneration
T2 - Cell reports. Medicine
J2 - Cell Rep Med
PY - 2026
DA - 2026/07/23
VL - 7
IS - 8
SP - 102937
SN - 2666-3791
PB - Elsevier
DO - 10.1016/j.xcrm.2026.102937
UR - https://doi.org/10.1016/j.xcrm.2026.102937
LA - en
ER -

CSL-JSON

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