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Repurposing <i>T‑614</i> for Gout: An In Silico Framework Integrating Network Pharmacology, Mendelian Randomization, and Single-Cell and Molecular Dynamics Analyses.

Overview

Authors: Huiqiong Zeng1, Songqing Lin2, Zebin Liu3, Junda Lai4, Wei Liu5,6, Ye Zhang2
ORCID iDs: Ye Zhang
  1. Department of Rheumatology, Women and Children Health Institute of Futian, Shenzhen 518000, China
  2. Traditional Chinese Medicine Department of Immunology, Women & Children Health Institute Futian Shenzhen, #2002 Jintian Road, Shenzhen 518000, China
  3. Department of Laboratory Medicine, Women and Children Health Institute of Futian, Shenzhen 518000, China
  4. Department of Human Life Sciences, Beijing Sport University, #48 Xinxi Road, Haidian District, Beijing 100029, China
  5. Department of Rheumatism and Immunity, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
  6. National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China
Institutions: Fujian Women and Children Hospital (China); Beijing Sport University (China); First Teaching Hospital of Tianjin University of Traditional Chinese Medicine (China)
Journal: ACS omega, volume 11, issue 25, pages 36608-36626
Dates: received 12 November 2025; accepted 9 June 2026; published online 16 June 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1021/acsomega.5c11807 · PMID 42396032 · PMCID PMC13325085 · OpenAlex W7164943766
Open access: gold, a free copy (OpenAlex)
Status: code on request
Categories: genetics / omics (modality), none (in silico) (organism), cellular / molecular (subfield)
Methods: Statistics, Smoothing, state filtering, decompositions, Machine learning
Topic: Gout, Hyperuricemia, Uric Acid (Nephrology, Medicine), according to OpenAlex
Citations: not cited yet (Europe PMC); 96 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Datasets cited

Code and data availability statement

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  • it says that the data are available on request
  • it says that the code is available on request

Read it in the paper: doi.org/10.1021/acsomega.5c11807.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 6 authors, 96 references.

Cite

This paper

Zeng, H., Lin, S., Liu, Z., Lai, J., Liu, W., & Zhang, Y. (2026). Repurposing <i>T‑614</i> for Gout: An In Silico Framework Integrating Network Pharmacology, Mendelian Randomization, and Single-Cell and Molecular Dynamics Analyses. ACS omega, 11(25), 36608-36626. https://doi.org/10.1021/acsomega.5c11807

BibTeX

@article{zeng2026repurposing,
author = {Zeng, Huiqiong and Lin, Songqing and Liu, Zebin and Lai, Junda and Liu, Wei and Zhang, Ye},
title = {{Repurposing \<i\>T‑614\</i\> for Gout: An In Silico Framework Integrating Network Pharmacology, Mendelian Randomization, and Single-Cell and Molecular Dynamics Analyses}},
journal = {ACS omega},
year = {2026},
month = jun,
volume = {11},
number = {25},
pages = {36608--36626},
publisher = {American Chemical Society},
issn = {2470-1343},
doi = {10.1021/acsomega.5c11807},
url = {https://doi.org/10.1021/acsomega.5c11807},
pmid = {42396032},
pmcid = {PMC13325085}
}

RIS

TY - JOUR
AU - Zeng, Huiqiong
AU - Lin, Songqing
AU - Liu, Zebin
AU - Lai, Junda
AU - Liu, Wei
AU - Zhang, Ye
TI - Repurposing <i>T‑614</i> for Gout: An In Silico Framework Integrating Network Pharmacology, Mendelian Randomization, and Single-Cell and Molecular Dynamics Analyses
T2 - ACS omega
J2 - ACS Omega
PY - 2026
DA - 2026/06/16
VL - 11
IS - 25
SP - 36608
EP - 36626
SN - 2470-1343
PB - American Chemical Society
DO - 10.1021/acsomega.5c11807
UR - https://doi.org/10.1021/acsomega.5c11807
LA - en
ER -

CSL-JSON

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"title": "Repurposing <i>T‑614</i> for Gout: An In Silico Framework Integrating Network Pharmacology, Mendelian Randomization, and Single-Cell and Molecular Dynamics Analyses",
"container-title": "ACS omega",
"author": [
{
"family": "Zeng",
"given": "Huiqiong"
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{
"family": "Lin",
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{
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{
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"container-title-short": "ACS Omega",
"volume": "11",
"issue": "25",
"page": "36608-36626",
"DOI": "10.1021/acsomega.5c11807",
"PMID": "42396032",
"PMCID": "PMC13325085",
"ISSN": "2470-1343",
"publisher": "American Chemical Society",
"URL": "https://doi.org/10.1021/acsomega.5c11807",
"language": "en",
"issued": {
"date-parts": [
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]
}
}

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