OSCR

NADPH oxidase-1 suppression prolongs the antidepressant-like effect of ketamine.

Overview

Authors: Waki Nakajima1, Tetsu Arisawa2, Susumu Jitsuki3, Tomomi Yamanoue1, Kaoru Fujikawa1, Megumi Hara1, Akane Sano1, Yuuki Takada1, Ryunosuke Iai1, Kimito Kimura1, Masataka Suzuki4, Mai Hatano1, Shariful A Syed1, Ayano Yajima1, Minami Nagata1, Taisuke Yatomi1, Hiroki Abe1, Takuya Takahashi1,5
ORCID iDs: Tetsu Arisawa, Shariful A Syed, Takuya Takahashi
  1. Department of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, 236-0004 Japan
  2. Radioisotope Research Center, Yokohama City University Graduate School of Medicine, Yokohama, 236-0004 Japan
  3. Department of Biochemistry, Mie University Graduate School of Medicine, Tsu, Mie 514-8507 Japan
  4. Department of Microbiology, Harvard Medical School, Division of Infectious Diseases, Brigham & Women’s Hospital, Boston, MA 02115 USA
  5. The International Research Center for Neurointelligence, Institutes for Advanced Study, University of Tokyo, Tokyo, 113-8654 Japan
Institutions: Yokohama City University (Japan); Mie University (Japan); Brigham and Women's Hospital (United States); Harvard University (United States); The University of Tokyo (Japan)
Journal: Molecular psychiatry, volume 31, issue 7, pages 4192-4204
Dates: received 17 July 2025; accepted 10 March 2026; published online 23 March 2026; in print 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41380-026-03527-1 · PMID 41872515 · PMCID PMC13269138 · OpenAlex W7140127544
Open access: hybrid, a free copy (OpenAlex)
Status: data only (how the code is found and verified)
Categories: rat (organism), depression (population)
Methods: Statistics, Physiology & signal measures
Keywords: Neuroscience, Depression
MeSH: Ketamine*, NADPH Oxidases*, Animals, Antidepressive Agents, Depression, Depressive Disorder, Treatment-Resistant, Disease Models, Animal, Male, Prefrontal Cortex, Rats, Rats, Inbred WKY, Receptors, AMPA, Receptors, N-Methyl-D-Aspartate (* major topic)
Topic: Treatment of Major Depression (Pharmacology (medical), Medicine), according to OpenAlex
Funding: MEXT | Japan Society for the Promotion of Science (JSPS) (JP25K22755, JP23K10432, JP20H05922, JP20H00549, JP24K02781); Japan Agency for Medical Research and Development (JP24wm0625304, JP19dm0207072); Takeda Medical Research Foundation; Takeda Science Foundation
Citations: not cited yet (Europe PMC); 71 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Datasets cited

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • it says that the data are available on request

Read it in the paper: doi.org/10.1038/s41380-026-03527-1.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 18 authors, 2 keywords, 13 MeSH terms, 4 funders, 69 references.

Cite

This paper

Nakajima, W., Arisawa, T., Jitsuki, S., Yamanoue, T., Fujikawa, K., Hara, M., Sano, A., Takada, Y., Iai, R., Kimura, K., Suzuki, M., Hatano, M., Syed, S. A., Yajima, A., Nagata, M., Yatomi, T., Abe, H., & Takahashi, T. (2026). NADPH oxidase-1 suppression prolongs the antidepressant-like effect of ketamine. Molecular psychiatry, 31(7), 4192-4204. https://doi.org/10.1038/s41380-026-03527-1

BibTeX

@article{nakajima2026nadph,
author = {Nakajima, Waki and Arisawa, Tetsu and Jitsuki, Susumu and Yamanoue, Tomomi and Fujikawa, Kaoru and Hara, Megumi and Sano, Akane and Takada, Yuuki and Iai, Ryunosuke and Kimura, Kimito and Suzuki, Masataka and Hatano, Mai and Syed, Shariful A and Yajima, Ayano and Nagata, Minami and Yatomi, Taisuke and Abe, Hiroki and Takahashi, Takuya},
title = {{NADPH oxidase-1 suppression prolongs the antidepressant-like effect of ketamine}},
journal = {Molecular psychiatry},
year = {2026},
month = mar,
volume = {31},
number = {7},
pages = {4192--4204},
publisher = {Springer Nature},
issn = {1359-4184},
doi = {10.1038/s41380-026-03527-1},
url = {https://doi.org/10.1038/s41380-026-03527-1},
pmid = {41872515},
pmcid = {PMC13269138}
}

RIS

TY - JOUR
AU - Nakajima, Waki
AU - Arisawa, Tetsu
AU - Jitsuki, Susumu
AU - Yamanoue, Tomomi
AU - Fujikawa, Kaoru
AU - Hara, Megumi
AU - Sano, Akane
AU - Takada, Yuuki
AU - Iai, Ryunosuke
AU - Kimura, Kimito
AU - Suzuki, Masataka
AU - Hatano, Mai
AU - Syed, Shariful A
AU - Yajima, Ayano
AU - Nagata, Minami
AU - Yatomi, Taisuke
AU - Abe, Hiroki
AU - Takahashi, Takuya
TI - NADPH oxidase-1 suppression prolongs the antidepressant-like effect of ketamine
T2 - Molecular psychiatry
J2 - Mol Psychiatry
PY - 2026
DA - 2026/03/23
VL - 31
IS - 7
SP - 4192
EP - 4204
SN - 1359-4184
PB - Springer Nature
DO - 10.1038/s41380-026-03527-1
UR - https://doi.org/10.1038/s41380-026-03527-1
LA - en
ER -

CSL-JSON

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"language": "en",
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