Multiscale characterization of cortical signatures in positive and negative schizotypy: a worldwide ENIGMA study.

1. Department of Psychiatry, University Hospitals of Geneva,Geneva, Switzerland
2. McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University,Montreal, QC Canada
3. Synapsy Center for Neuroscience and Mental Health Research, University of Geneva,Geneva, Switzerland
4. Psychiatric University Hospital Zurich, University of Zurich,Zurich, Switzerland
5. Department of Psychiatry, University of California San Diego,San Diego, CA USA
6. Children’s Hospital of Philadelphia, University of Pennsylvania,Philadelphia, USA
7. Center for Biomedical Image Computing and Analytics, Perelman School of Medicine, University of Pennsylvania,Philadelphia, PA USA
8. University of Marburg,Marburg, Germany
9. Department of Psychiatry and Psychotherapy, University Hospital Bonn,Bonn, Germany
10. Institute for Translational Psychiatry, University of Münster,Münster, Germany
11. Department of Psychiatry, Medical School and University Medical Center OWL, Protestant Hospital of the Bethel Foundation, Bielefeld University,Bielefeld, Germany
12. German Center for Mental Health (DZPG), Site Jena Magdeburg Halle,Jena, Germany
13. Center for Intervention and Research on Adaptive and Maladaptive Brain Circuits Underlying Mental Health (C-I-R-C), Site Jena Magdeburg Halle, Jena, Germany
14. Institute for Translational Neuroscience, University of Münster,Münster, Germany
15. Department of Psychiatry and Psychotherapy, Charité University Medicine,Berlin, Germany
16. Turner Institute for Brain and Mental Health, School of Psychological Sciences and Monash Biomedical Imaging, Monash University,Melbourne, VIC Australia
17. Stony Brook University,Stony Brook, NY USA
18. Division of Psychiatry Research, Zucker Hillside Hospital, Northwell Health,Glen Oaks, NY USA
19. The Feinstein Institutes for Medical Research, Center for Psychiatric Neuroscience,Manhasset, NY USA
20. Department of Psychiatry, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell,Hempstead, NY USA
21. School of Clinical Medicine, University of New South Wales (UNSW),Sydney, NSW Australia
22. School of Psychology, The University of New South Wales (UNSW),Sydney, NSW Australia
23. Neuroscience Research Australia (NeuRA),Randwick, NSW Australia
24. Department of Psychiatry, University of Melbourne,Carlton South, VIC Australia
25. State Key Laboratory of Cognitive Science and Mental Health, Institute of Psychology, Chinese Academy of Sciences,Beijing, China
26. University of Bonn,Bonn, Germany
27. Faculty of Psychology and Educational Sciences, University of Geneva,Geneva, Switzerland
28. Research Department of Clinical, Educational and Health Psychology, University College London,London, UK
29. Department of Psychiatry and Psychotherapy, Jena University Hospital,Jena, Germany
30. Department of Neurology, Jena University Hospital,Jena, Germany
31. Department of Psychosis Studies, King’s College London,London, UK
32. Department of Psychiatry, University of Melbourne and Mental Services, Northern Health,Victoria, Australia
33. FIDMAG Germanes Hospitalàries Research Foundation & CIBERSAM, ISCIII,Barcelona, Spain
34. Institute of Psychiatry, School of Medicine, University of Sao Paulo,Sao Paulo, Brazil
35. Brunel University London,Uxbridge, UK
36. School of Psychology, University of Auckland,Auckland, New Zealand
37. Vrije Universiteit Amsterdam,Amsterdam, the Netherlands
38. University of Manchester,Manchester, UK
39. Neuroimaging, Institute of Psychiatry, Psychology, Neuroscience, King’s College London,London, UK
40. Department of Biomedical Sciences of Cells and Systems, University Medical Center Groningen, University of Groningen,Groningen, the Netherlands
41. Mental Health Research Center,Moscow, Russian Federation
42. Department of Psychology and Neuroscience, City St George’s, University of London, School of Health and Medical Sciences,London, UK
43. Fresenius University of Applied Sciences,Frankfurt am Main, Germany
44. Department of Psychiatry & Neuropsychology, Mental Health and Neuroscience (MHeNs) Research Institute, Maastricht University,Maastricht, Netherlands
45. Department of Psychiatry and Behavioral Sciences, Boston Children’s Hospital,Boston, MA USA
46. Department of Psychiatry, Harvard Medical School,MA Boston, USA
47. Institute of Neuroscience and Medicine (INM-7: Brain & Behaviour) Research Centre Jülich,Jülich, Germany
48. Department of Medical Imaging and Radiation Sciences, Université de Sherbrooke,Sherbrooke, QC Canada
49. Max Planck Institute for Human Cognitive and Brain Sciences,Leipzig, Germany
50. Institute of Systems Neuroscience, Heinrich Heine University Düsseldorf,Düsseldorf, Germany
51. Clinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, University of California Irvine,Irvine, CA USA
52. Center for the Neurobiology of Learning and Memory, University of California Irvine,Irvine, CA USA
53. Department of Psychiatry and Behavioral Health, the Ohio State University,Columbus, OH USA
54. Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of the University of Southern California,Marina del Rey, CA USA
55. Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University,Maastricht, the Netherlands
56. Department of Psychological Medicine, Institute of Psychiatry, Psychology, and Neuroscience, King’s College London,London, UK
57. MRC Centre for Neurodevelopmental Disorders, King’s College London,London, UK

@article{kirschner2026multiscale,
author = {Kirschner, Matthias and Hodzic-Santor, Benazir and Kennedy, Leda and Hansen, Justine Y. and Antoniades, Mathilde and Nenadić, Igor and Kircher, Tilo and Krug, Axel and Meller, Tina and Dannlowski, Udo and Grotegerd, Dominik and Flinkenflügel, Kira and Meinert, Susanne and Borgers, Tiana and Goltermann, Janik and Hahn, Tim and Böhnlein, Joscha and Leehr, Elisabeth J. and Barkhau, Carlotta and Fornito, Alex and Arnatkeviciute, Aurina and Bellgrove, Mark A. and Tiego, Jeggan and DeRosse, Pamela and Green, Melissa and Quidé, Yann and Pantelis, Christos and Chan, Raymond C. K. and Wang, Yi and Ettinger, Ulrich and Debbané, Martin and Derome, Melodie and Gaser, Christian and Besteher, Bianca and Diederen, Kelly and Spencer, Tom J. and Houenou, Josselin and Pomarol-Clotet, Edith and Salvador, Raymond and Rössler, Wulf and Smigielski, Lukasz and Kumari, Veena and Premkumar, Preethi and Park, Haeme R. P. and Wiebels, Kristina and Jansen, Imke and Gilleen, James and Allen, Paul and Marsman, Jan-Bernard and Lebedeva, Irina and Tomyshev, Alexander and Fett, Anne-Kathrin and Sommer, Iris and Koops, Sanne and Grant, Phillip and Ferrari, Asia and Wan, Bin and Bègue, Indrit and Hernaus, Dennis and Jalbrzikowski, Maria and Paquola, Casey and Larivière, Sara and Bernhardt, Boris and Valk, Sofie L. and Misic, Bratislav and van Erp, Theo G. M. and Turner, Jessica A. and Thompson, Paul M. and Aleman, Andre and Dagher, Alain and Kaiser, Stefan and Modinos, Gemma},
title = {{Multiscale characterization of cortical signatures in positive and negative schizotypy: a worldwide ENIGMA study}},
journal = {Molecular psychiatry},
year = {2026},
month = apr,
volume = {31},
number = {9},
pages = {4846--4860},
publisher = {Springer Nature},
issn = {1359-4184},
doi = {10.1038/s41380-026-03547-x},
url = {https://doi.org/10.1038/s41380-026-03547-x},
pmid = {42000906},
pmcid = {PMC13441894}
}

TY - JOUR
AU - Kirschner, Matthias
AU - Hodzic-Santor, Benazir
AU - Kennedy, Leda
AU - Hansen, Justine Y.
AU - Antoniades, Mathilde
AU - Nenadić, Igor
AU - Kircher, Tilo
AU - Krug, Axel
AU - Meller, Tina
AU - Dannlowski, Udo
AU - Grotegerd, Dominik
AU - Flinkenflügel, Kira
AU - Meinert, Susanne
AU - Borgers, Tiana
AU - Goltermann, Janik
AU - Hahn, Tim
AU - Böhnlein, Joscha
AU - Leehr, Elisabeth J.
AU - Barkhau, Carlotta
AU - Fornito, Alex
AU - Arnatkeviciute, Aurina
AU - Bellgrove, Mark A.
AU - Tiego, Jeggan
AU - DeRosse, Pamela
AU - Green, Melissa
AU - Quidé, Yann
AU - Pantelis, Christos
AU - Chan, Raymond C. K.
AU - Wang, Yi
AU - Ettinger, Ulrich
AU - Debbané, Martin
AU - Derome, Melodie
AU - Gaser, Christian
AU - Besteher, Bianca
AU - Diederen, Kelly
AU - Spencer, Tom J.
AU - Houenou, Josselin
AU - Pomarol-Clotet, Edith
AU - Salvador, Raymond
AU - Rössler, Wulf
AU - Smigielski, Lukasz
AU - Kumari, Veena
AU - Premkumar, Preethi
AU - Park, Haeme R. P.
AU - Wiebels, Kristina
AU - Jansen, Imke
AU - Gilleen, James
AU - Allen, Paul
AU - Marsman, Jan-Bernard
AU - Lebedeva, Irina
AU - Tomyshev, Alexander
AU - Fett, Anne-Kathrin
AU - Sommer, Iris
AU - Koops, Sanne
AU - Grant, Phillip
AU - Ferrari, Asia
AU - Wan, Bin
AU - Bègue, Indrit
AU - Hernaus, Dennis
AU - Jalbrzikowski, Maria
AU - Paquola, Casey
AU - Larivière, Sara
AU - Bernhardt, Boris
AU - Valk, Sofie L.
AU - Misic, Bratislav
AU - van Erp, Theo G. M.
AU - Turner, Jessica A.
AU - Thompson, Paul M.
AU - Aleman, Andre
AU - Dagher, Alain
AU - Kaiser, Stefan
AU - Modinos, Gemma
TI - Multiscale characterization of cortical signatures in positive and negative schizotypy: a worldwide ENIGMA study
T2 - Molecular psychiatry
J2 - Mol Psychiatry
PY - 2026
DA - 2026/04/18
VL - 31
IS - 9
SP - 4846
EP - 4860
SN - 1359-4184
PB - Springer Nature
DO - 10.1038/s41380-026-03547-x
UR - https://doi.org/10.1038/s41380-026-03547-x
LA - en
ER -

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