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Sex-specific neurodevelopmental pathways to depressive symptoms.

Overview

Authors: Shi Yu Chan1, Pei Huang1, Zhen Ming Ngoh1, Joanne S M Chia1, Janice Lee1, Aisleen M A Manahan1, Jasmine S M Chuah1, Marielle V Fortier1,2,3, Fabian Yap3,4,5, Yap-Seng Chong1,6,7, Peter Gluckman1,8, Johan Eriksson1,6,7,9,10, Michael J Meaney11, Ai Peng Tan1,6,12
ORCID iDs: Shi Yu Chan, Janice Lee, Jasmine S M Chuah, Peter Gluckman, Michael J Meaney, Ai Peng Tan
  1. Institute for Human Development and Potential, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore
  2. Department of Diagnostic and Interventional Imaging, KK Women’s and Children’s Hospital, Singapore, Singapore
  3. Duke-NUS Medical School, Singapore, Singapore
  4. Department of Paediatrics, KK Women’s and Children’s Hospital, Singapore, Singapore
  5. Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore
  6. Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
  7. Department of Obstetrics & Gynaecology, National University Health System, Singapore, Singapore
  8. Liggins Institute, University of Auckland, Auckland, New Zealand
  9. Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
  10. Folkhälsan Research Centre, Folkhälsan, Helsinki, Finland
  11. Douglas Hospital Research Centre, Department of Psychiatry, McGill University, Montreal, Canada
  12. Department of Diagnostic Imaging, National University Health System, Singapore, Singapore
Institutions: Agency for Science, Technology and Research (Singapore); KK Women's and Children's Hospital (Singapore); Duke-NUS Medical School (Singapore); Nanyang Technological University (Singapore); National University of Singapore (Singapore); National University Health System (Singapore); University of Auckland (New Zealand); University of Helsinki (Finland); Helsinki University Hospital (Finland); Folkhälsans Forskningscentrum (Finland); Douglas Mental Health University Institute (Canada); McGill University (Canada)
Journal: Molecular psychiatry, volume 31, issue 8, pages 4563-4575
Dates: received 11 September 2025; accepted 20 March 2026; published online 1 April 2026; in print 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41380-026-03576-6 · PMID 41922795 · PMCID PMC13364716 · OpenAlex W7147180215
Open access: hybrid, a free copy (OpenAlex)
Status: code on request
Categories: human (organism), depression (population)
Methods: Statistics, Smoothing, state filtering, decompositions, Connectivity, fMRI & imaging
Keywords: Predictive markers, Depression
MeSH: Depression*, Adolescent, Brain, Brain Mapping, Cerebral Cortex, Child, Child, Preschool, Female, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Neurodevelopment, Neuroimaging, Sex Characteristics, Sex Factors (* major topic)
Topic: Functional Brain Connectivity Studies (Cognitive Neuroscience, Neuroscience), according to OpenAlex
Funding: MOH | National Medical Research Council (NMRC) (MOH-001149-00, MOH-001273-00); Agency for Science Technology and Research, Singapore; Agency for Science, Technology and Research (C222812035)
Citations: cited by 1 paper (Europe PMC); 72 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Code availability statement

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  • it says that the code is available on request

Read it in the paper: doi.org/10.1038/s41380-026-03576-6.

Tracing map

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Data

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Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • it says that the data are available on request

Read it in the paper: doi.org/10.1038/s41380-026-03576-6.

Versions

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Version 2, 28 September 2026

  • Publisher: n/a → Springer Nature

Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 14 authors, 2 keywords, 16 MeSH terms, 3 funders, 62 references.

Cite

This paper

Chan, S. Y., Huang, P., Ngoh, Z. M., Chia, J. S. M., Lee, J., Manahan, A. M. A., Chuah, J. S. M., Fortier, M. V., Yap, F., Chong, Y.-S., Gluckman, P., Eriksson, J., Meaney, M. J., & Tan, A. P. (2026). Sex-specific neurodevelopmental pathways to depressive symptoms. Molecular psychiatry, 31(8), 4563-4575. https://doi.org/10.1038/s41380-026-03576-6

BibTeX

@article{chan2026sex,
author = {Chan, Shi Yu and Huang, Pei and Ngoh, Zhen Ming and Chia, Joanne S M and Lee, Janice and Manahan, Aisleen M A and Chuah, Jasmine S M and Fortier, Marielle V and Yap, Fabian and Chong, Yap-Seng and Gluckman, Peter and Eriksson, Johan and Meaney, Michael J and Tan, Ai Peng},
title = {{Sex-specific neurodevelopmental pathways to depressive symptoms}},
journal = {Molecular psychiatry},
year = {2026},
month = apr,
volume = {31},
number = {8},
pages = {4563--4575},
publisher = {Springer Nature},
issn = {1359-4184},
doi = {10.1038/s41380-026-03576-6},
url = {https://doi.org/10.1038/s41380-026-03576-6},
pmid = {41922795},
pmcid = {PMC13364716}
}

RIS

TY - JOUR
AU - Chan, Shi Yu
AU - Huang, Pei
AU - Ngoh, Zhen Ming
AU - Chia, Joanne S M
AU - Lee, Janice
AU - Manahan, Aisleen M A
AU - Chuah, Jasmine S M
AU - Fortier, Marielle V
AU - Yap, Fabian
AU - Chong, Yap-Seng
AU - Gluckman, Peter
AU - Eriksson, Johan
AU - Meaney, Michael J
AU - Tan, Ai Peng
TI - Sex-specific neurodevelopmental pathways to depressive symptoms
T2 - Molecular psychiatry
J2 - Mol Psychiatry
PY - 2026
DA - 2026/04/01
VL - 31
IS - 8
SP - 4563
EP - 4575
SN - 1359-4184
PB - Springer Nature
DO - 10.1038/s41380-026-03576-6
UR - https://doi.org/10.1038/s41380-026-03576-6
LA - en
ER -

CSL-JSON

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