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Targeting ATP11B-YAP axis repairs mitochondrial function and inhibits neuronal ferroptosis to attenuate age-related cognitive decline.

Overview

Authors: Wenxin Qi1,2, Qian Liu1, Naijun Dong1,3, Xiuqiao Sun4, Peiru Wu1, Jianxin Zhou1, Ruiqi Sun1, Yihao Liu5, Robert Chunhua Zhao1,6,7,8, Jiao Wang1,9,10,11
ORCID iDs: Yihao Liu, Robert Chunhua Zhao, Jiao Wang
  1. School of Life Sciences, Shanghai University, Shanghai, China
  2. Shanghai Institute of Nutrition and Health, Chinese Academy of Science, Shanghai, China
  3. Jinan Microecological Biomedicine Shandong Laboratory, Jinan, China
  4. Cancer Institute/Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shangh, China
  5. Department of General Surgery, Pancreatic Disease Center, Research Institute of Pancreatic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
  6. Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China
  7. Centre of Excellence in Tissue Engineering, Chinese Academy of Medical Sciences, Beijing, China
  8. Beijing Key Laboratory of New Drug Development and Clinical Trial of Stem Cell Therapy, Beijing, China
  9. School of Life Science and Technology, Shandong Vocational University of Foreign Affairs, Jinan, China
  10. Department of Rehabilitation Medicine, The Affiliated Taian City Central Hospital of Qingdao University, Taian, China
  11. Key Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission, Northwest Minzu University, Lanzhou, Gansu China
Institutions: Shanghai University (China); Chinese Academy of Sciences (China); Shanghai Institute of Nutrition and Health (China); Shanghai University of Traditional Chinese Medicine (China); Longhua Hospital Shanghai University of Traditional Chinese Medicine (China); Shanghai Jiao Tong University (China); Ruijin Hospital (China); Chinese Academy of Medical Sciences & Peking Union Medical College (China); Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences; Qingdao University (China); Northwest Minzu University (China); Taian City Central Hospital (China); Shandong Vocational University of Foreign Affairs (China)
Journal: Signal transduction and targeted therapy, volume 11, issue 1, article 141
Dates: received 1 August 2025; accepted 13 February 2026; published online 20 April 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41392-026-02652-1 · PMID 42002550 · PMCID PMC13092642 · OpenAlex W7154916568
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: human (organism), mouse (organism), cellular / molecular (subfield)
Keywords: Cell death in the nervous system, Senescence, Epigenetics
MeSH: Aging*, Cognitive Dysfunction*, Ferroptosis*, Mitochondria*, Transcription Factors*, Animals, Hippocampus, Humans, Iron, Kruppel-Like Factor 4, Kruppel-Like Transcription Factors, Mice, Neurons, Reactive Oxygen Species, Signal Transduction, YAP-Signaling Proteins (* major topic)
Topic: Ferroptosis and cancer prognosis (Pulmonary and Respiratory Medicine, Medicine), according to OpenAlex
Funding: National Natural Science Foundation of China (81971324, I2M-1-012, 2018YFA0109800, 82503169); Natural Science Foundation of Shandong Province (ZR2021MH304); National Key Research and Development Program of China (20 18YFA0109800, 2022-I2M-1-012, 20JC1412200, 2020YFA0113000)
Citations: not cited yet (Europe PMC); 41 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

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Data

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Data availability statement

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Read it in the paper: doi.org/10.1038/s41392-026-02652-1.

Versions

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Version 1, 29 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 10 authors, 3 keywords, 16 MeSH terms, 3 funders, 41 references.

Cite

This paper

Qi, W., Liu, Q., Dong, N., Sun, X., Wu, P., Zhou, J., Sun, R., Liu, Y., Zhao, R. C., & Wang, J. (2026). Targeting ATP11B-YAP axis repairs mitochondrial function and inhibits neuronal ferroptosis to attenuate age-related cognitive decline. Signal transduction and targeted therapy, 11(1), 141. https://doi.org/10.1038/s41392-026-02652-1

BibTeX

@article{qi2026targeting,
author = {Qi, Wenxin and Liu, Qian and Dong, Naijun and Sun, Xiuqiao and Wu, Peiru and Zhou, Jianxin and Sun, Ruiqi and Liu, Yihao and Zhao, Robert Chunhua and Wang, Jiao},
title = {{Targeting ATP11B-YAP axis repairs mitochondrial function and inhibits neuronal ferroptosis to attenuate age-related cognitive decline}},
journal = {Signal transduction and targeted therapy},
year = {2026},
month = apr,
volume = {11},
number = {1},
pages = {141},
publisher = {Nature Publishing Group},
issn = {2095-9907},
doi = {10.1038/s41392-026-02652-1},
url = {https://doi.org/10.1038/s41392-026-02652-1},
pmid = {42002550},
pmcid = {PMC13092642}
}

RIS

TY - JOUR
AU - Qi, Wenxin
AU - Liu, Qian
AU - Dong, Naijun
AU - Sun, Xiuqiao
AU - Wu, Peiru
AU - Zhou, Jianxin
AU - Sun, Ruiqi
AU - Liu, Yihao
AU - Zhao, Robert Chunhua
AU - Wang, Jiao
TI - Targeting ATP11B-YAP axis repairs mitochondrial function and inhibits neuronal ferroptosis to attenuate age-related cognitive decline
T2 - Signal transduction and targeted therapy
J2 - Signal Transduct Target Ther
PY - 2026
DA - 2026/04/20
VL - 11
IS - 1
SP - 141
SN - 2095-9907
PB - Nature Publishing Group
DO - 10.1038/s41392-026-02652-1
UR - https://doi.org/10.1038/s41392-026-02652-1
LA - en
ER -

CSL-JSON

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