Bridging molecules and connectome: network biomarkers guided by neurotransmitter architecture in major depressive disorder.

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Paper

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The authors' code

MATLAB · 5 lines · 100 B · no license

function y = aprior(gamma_hat)
m = mean(gamma_hat);
s2 = var(gamma_hat);
y=(2*s2+m^2)/s2;
end

aprior.m at commit 91f8bf3, no license · at the source

Overview

Authors: Qiuyu Lv^1,2, Daifeng Dong^1,2, Shulin Fang^1,2, Xuanyi Wang³, Pan Lin³, the ZIB Consortium, Jianfeng Feng^4,5, Qiang Luo^4,6, Xiang Wang^1,2

ORCID iDs: Qiuyu Lv, Jianfeng Feng, Qiang Luo, Xiang Wang

Medical Psychological Center, The Second Xiangya Hospital of Central South University,Changsha, Hunan 410011 PR China
China National Clinical Research Center for Mental Disorders (Xiangya),Changsha, Hunan 410011 PR China
Center for Mind & Brain Sciences and Institute of Interdisciplinary Studies, Hunan Normal University,Changsha, Hunan 410081 PR China
Institute of Science and Technology for Brain-Inspired Intelligence, Research Institute of Intelligent Complex System, Fudan University,Shanghai, 200433 PR China
Department of Computer Science, University of Warwick,Coventry, UK
State Key Laboratory of Brain Function and Disorders and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University,Shanghai, 200032 China

Institutions: Central South University (China); Second Xiangya Hospital of Central South University (China); Hunan Normal University (China); Fudan University (China); University of Warwick (United Kingdom)

Journal: Translational psychiatry, volume 16, issue 1, article 339

Dates: received 17 September 2025; accepted 30 April 2026; published online 13 May 2026

Type: Research article · Language: English

License: CC BY-NC-ND

Identifiers: DOI 10.1038/s41398-026-04100-8 · PMID 42129144 · PMCID PMC13342443 · OpenAlex W7160986177

Open access: gold, a free copy (OpenAlex)

Status: code verified

Categories: human (organism), depression (population), clinical / translational (subfield)

Methods: Spectral & time-frequency, Statistics, Machine learning, Preprocessing, Connectivity, fMRI & imaging

Keywords: Diagnostic markers, Depression

MeSH: Brain*, Connectome*, Major Depressive Disorder*, Neurotransmitter Agents*, Adult, Biomarkers, Case-Control Studies, Dopamine Plasma Membrane Transport Proteins, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged (* major topic)

Topic: Tryptophan and brain disorders (Biological Psychiatry, Neuroscience), according to OpenAlex

Funding: National Natural Science Foundation of China (National Science Foundation of China) (32371136, 32400916, 32441107, 82272079); National Key Research and Development Program of China (No. 2023YFE0109700); Program of Shanghai Academic Research Leader (No. 23XD1423400)

Citations: not cited yet (Europe PMC); 71 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Repository

Its files are read in the Code ↔ Paper reader above.

Jfortin1/ComBatHarmonization

License: none: the authors keep all their rights

State: the link answers, verified on 26 September 2026

Evidence: files inventoried

Commit: 91f8bf3045381776c79358d2772e6ace135e21ce, 27 July 2021

Languages: MATLAB (8), R (6), Python (2)

Size: 102 files, 16 scripts

Software Heritage: not archived

Found in: “Code availability”

Holds: README

Not found: license file, CITATION.cff, environment file, tests, continuous integration, documentation

Tools: neuroCombat (5 files), NumPy (2 files), pandas (2 files), tidyverse (2 files)

Availability: 1 check, the latest on 26 September 2026: the link answers

26 September 2026: the link answers

17 files

Matlab/scripts/aprior.m, MATLAB, 5 lines
Matlab/scripts/bprior.m, MATLAB, 5 lines
Matlab/scripts/combat.m, MATLAB, 127 lines
Matlab/scripts/inteprior.m, MATLAB, 27 lines
Matlab/scripts/itSol.m, MATLAB, 18 lines
Matlab/scripts/postmean.m, MATLAB, 3 lines
Matlab/scripts/postvar.m, MATLAB, 3 lines
Testing/compare.R, R, 45 lines
Testing/compareToSva.R, R, 75 lines
Testing/compare_training.R, R, 11 lines
Testing/createTestData.R, R, 9 lines
Testing/norm_matlab.m, MATLAB, 20 lines
Testing/norm_python.py, Python, 123 lines
Testing/norm_python_training.py, Python, 51 lines
Testing/norm_r.R, R, 95 lines
Testing/norm_r_training.R, R, 56 lines
README.md, Text, 119 lines

At the source: github.com/Jfortin1/ComBatHarmonization

Code availability statement

The paper has a code availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

it points to the authors' code: Jfortin1/ComBatHarmonization
it says that the code is available on request

Read it in the paper: doi.org/10.1038/s41398-026-04100-8.

Tracing map

Proposed by the machine: these links were found in the paper and verified at the source, without human review. The map will receive a Zenodo DOI once one of the paper's authors has validated it with their ORCID.

What the map holds:

1 repository of the authors' code, each at its verified commit, with its license and how the link was found in the paper;
16 scripts, each with its path and the digest of its content;
no match between paragraphs and code yet;
neither the text of the paper nor the code itself.

Its JSON (tracing-map.json) is deposited on Zenodo with its DOI once the map is validated.

Data

No dataset and no data link were found in the paper.

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

it says that the data are available on request

Read it in the paper: doi.org/10.1038/s41398-026-04100-8.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 9 authors, 2 keywords, 13 MeSH terms, 3 funders, 71 references.

Cite

This paper

Lv, Q., Dong, D., Fang, S., Wang, X., Lin, P., the ZIB Consortium, Feng, J., Luo, Q., & Wang, X. (2026). Bridging molecules and connectome: network biomarkers guided by neurotransmitter architecture in major depressive disorder. Translational psychiatry, 16(1), 339. https://doi.org/10.1038/s41398-026-04100-8

BibTeX

@article{lv2026bridging, author = {Lv, Qiuyu and Dong, Daifeng and Fang, Shulin and Wang, Xuanyi and Lin, Pan and {the ZIB Consortium} and Feng, Jianfeng and Luo, Qiang and Wang, Xiang}, title = {{Bridging molecules and connectome: network biomarkers guided by neurotransmitter architecture in major depressive disorder}}, journal = {Translational psychiatry}, year = {2026}, month = may, volume = {16}, number = {1}, pages = {339}, publisher = {Nature Publishing Group}, issn = {2158-3188}, doi = {10.1038/s41398-026-04100-8}, url = {https://doi.org/10.1038/s41398-026-04100-8}, pmid = {42129144}, pmcid = {PMC13342443} }

RIS

TY - JOUR AU - Lv, Qiuyu AU - Dong, Daifeng AU - Fang, Shulin AU - Wang, Xuanyi AU - Lin, Pan AU - the ZIB Consortium AU - Feng, Jianfeng AU - Luo, Qiang AU - Wang, Xiang TI - Bridging molecules and connectome: network biomarkers guided by neurotransmitter architecture in major depressive disorder T2 - Translational psychiatry J2 - Transl Psychiatry PY - 2026 DA - 2026/05/13 VL - 16 IS - 1 SP - 339 SN - 2158-3188 PB - Nature Publishing Group DO - 10.1038/s41398-026-04100-8 UR - https://doi.org/10.1038/s41398-026-04100-8 LA - en ER -

CSL-JSON

{ "id": "10.1038/s41398-026-04100-8", "type": "article-journal", "title": "Bridging molecules and connectome: network biomarkers guided by neurotransmitter architecture in major depressive disorder", "container-title": "Translational psychiatry", "author": [ { "family": "Lv", "given": "Qiuyu" }, { "family": "Dong", "given": "Daifeng" }, { "family": "Fang", "given": "Shulin" }, { "family": "Wang", "given": "Xuanyi" }, { "family": "Lin", "given": "Pan" }, { "literal": "the ZIB Consortium" }, { "family": "Feng", "given": "Jianfeng" }, { "family": "Luo", "given": "Qiang" }, { "family": "Wang", "given": "Xiang" } ], "container-title-short": "Transl Psychiatry", "volume": "16", "issue": "1", "page": "339", "DOI": "10.1038/s41398-026-04100-8", "PMID": "42129144", "PMCID": "PMC13342443", "ISSN": "2158-3188", "publisher": "Nature Publishing Group", "URL": "https://doi.org/10.1038/s41398-026-04100-8", "language": "en", "issued": { "date-parts": [ [ 2026, 5, 13 ] ] } }

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