OSCR

A nucleus accumbens-projecting prefrontal cortex circuit underlies chronic social stress-induced depression-like behaviors.

Overview

Authors: Xiaokuang Ma1, Heedae Kim1, Le Zhang1, Peng Chen1, Jing Wei1, Yuehua Cui1, Lishu Chen1, Yuan Xu1, John Zhang1, Zhiyu Dai2, Deveroux Ferguson1, Shenfeng Qiu1,3
ORCID iDs: Xiaokuang Ma, Zhiyu Dai, Shenfeng Qiu
  1. Basic Medical Sciences, University of Arizona College of Medicine-Phoenix, Phoenix, AZ 85004 USA
  2. Department of Medicine, University of Arizona College of Medicine-Phoenix, Phoenix, AZ 85004 USA
  3. Translational Neuroscience, University of Arizona College of Medicine-Phoenix, Phoenix, AZ 85004 USA
Institutions: University of Arizona College of Medicine- Phoenix (United States)
Journal: Translational psychiatry, volume 16, issue 1, article 403
Dates: received 29 September 2025; accepted 19 May 2026; published online 4 June 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41398-026-04128-w · PMID 42243077 · PMCID PMC13454594 · OpenAlex W7163580670
Open access: gold, a free copy (OpenAlex)
Status: code on request
Categories: mouse (organism), depression (population), systems (subfield)
Methods: Statistics, Evoked potentials
Keywords: Molecular neuroscience, Physiology
MeSH: Major Depressive Disorder*, Nucleus Accumbens*, Prefrontal Cortex*, Stress, Psychological*, Animals, Behavior, Animal, Excitatory Postsynaptic Potentials, Male, Mice, Mice, Inbred C57BL, Neural Pathways, Neurons, Optogenetics, Social Defeat (* major topic)
Topic: Neurotransmitter Receptor Influence on Behavior (Cellular and Molecular Neuroscience, Neuroscience), according to OpenAlex
Funding: U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (MH128192); NIMH NIH HHS (R01 MH128192); U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) (MH128192); ADHS | Arizona Biomedical Research Commission
Citations: not cited yet (Europe PMC); 39 references in the paper
Research resources: we used GABA antibody RRID:AB_477652

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

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Code and data availability statement

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  • it says that the code is available on request

Read it in the paper: doi.org/10.1038/s41398-026-04128-w.

Versions

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 12 authors, 2 keywords, 14 MeSH terms, 4 funders, 39 references, 1 RRID.

Cite

This paper

Ma, X., Kim, H., Zhang, L., Chen, P., Wei, J., Cui, Y., Chen, L., Xu, Y., Zhang, J., Dai, Z., Ferguson, D., & Qiu, S. (2026). A nucleus accumbens-projecting prefrontal cortex circuit underlies chronic social stress-induced depression-like behaviors. Translational psychiatry, 16(1), 403. https://doi.org/10.1038/s41398-026-04128-w

BibTeX

@article{ma2026nucleus,
author = {Ma, Xiaokuang and Kim, Heedae and Zhang, Le and Chen, Peng and Wei, Jing and Cui, Yuehua and Chen, Lishu and Xu, Yuan and Zhang, John and Dai, Zhiyu and Ferguson, Deveroux and Qiu, Shenfeng},
title = {{A nucleus accumbens-projecting prefrontal cortex circuit underlies chronic social stress-induced depression-like behaviors}},
journal = {Translational psychiatry},
year = {2026},
month = jun,
volume = {16},
number = {1},
pages = {403},
publisher = {Nature Publishing Group},
issn = {2158-3188},
doi = {10.1038/s41398-026-04128-w},
url = {https://doi.org/10.1038/s41398-026-04128-w},
pmid = {42243077},
pmcid = {PMC13454594}
}

RIS

TY - JOUR
AU - Ma, Xiaokuang
AU - Kim, Heedae
AU - Zhang, Le
AU - Chen, Peng
AU - Wei, Jing
AU - Cui, Yuehua
AU - Chen, Lishu
AU - Xu, Yuan
AU - Zhang, John
AU - Dai, Zhiyu
AU - Ferguson, Deveroux
AU - Qiu, Shenfeng
TI - A nucleus accumbens-projecting prefrontal cortex circuit underlies chronic social stress-induced depression-like behaviors
T2 - Translational psychiatry
J2 - Transl Psychiatry
PY - 2026
DA - 2026/06/04
VL - 16
IS - 1
SP - 403
SN - 2158-3188
PB - Nature Publishing Group
DO - 10.1038/s41398-026-04128-w
UR - https://doi.org/10.1038/s41398-026-04128-w
LA - en
ER -

CSL-JSON

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