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Targeting notch signaling to restore neural development and behavior in mouse models of ASD.

Overview

Authors: Yoko Hanno1,2, Moe Nakanishi3, Akinori Takase4, Jun Nomura5, Masami Tanaka1, Yumi Iida4, Masayuki Tanaka4, Hiroyuki Hosokawa6, Masatoshi Ito7, Katsunaka Mikami8, Katsuto Hozumi6, Goichi Miyoshi9, Toru Takumi3,5, Takatoshi Iijima1,10
ORCID iDs: Yoko Hanno, Jun Nomura, Masami Tanaka, Masayuki Tanaka, Hiroyuki Hosokawa, Masatoshi Ito, Goichi Miyoshi, Toru Takumi, Takatoshi Iijima
  1. Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, Isehara, Kanagawa Japan
  2. Present Address: Laboratory for Neural Cell Dynamics, RIKEN Center for Brain Science, Saitama, Japan
  3. RIKEN Center for Brain Science, Wako, Saitama, Japan
  4. The Support Center for Medical Research and Education, Tokai University, Isehara, Kanagawa Japan
  5. Department of Physiology and Cell Biology, Kobe University School of Medicine, Chuo, Kobe, Japan
  6. Department of Immunology, Tokai University School of Medicine, Isehara, Kanagawa Japan
  7. Department of Legal Medicine, St. Marianna University School of Medicine, Kawasaki, Kanagawa Japan
  8. Department of Psychiatry, Tokai University School of Medicine, Isehara, Kanagawa Japan
  9. Department of Developmental Genetics and Behavioral Neuroscience, Gunma University Graduate School of Medicine, Gunma, Japan
  10. Present Address: Department of Anatomy, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, Isehara, Kanagawa Japan
Institutions: Tokai University (Japan); RIKEN Center for Brain Science (Japan); Kobe University (Japan); St. Marianna University School of Medicine (Japan); Gunma University (Japan)
Journal: Nature communications, volume 17, issue 1, article 2587
Dates: received 16 April 2025; accepted 23 February 2026; published online 30 March 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41467-026-70321-6 · PMID 41912527 · PMCID PMC13036009 · OpenAlex W7143442819
Open access: gold, a free copy (OpenAlex)
Status: data only (how the code is found and verified)
Categories: human (organism), mouse (organism), autism (population)
Methods: Preprocessing, Statistics, Smoothing, state filtering, decompositions, Connectivity, Machine learning
Keywords: Autism spectrum disorders, Epigenetics and behaviour, Social behaviour, Cell fate and cell lineage
MeSH: Autism Spectrum Disorder*, Neurogenesis*, Receptor, Notch1*, Receptor, Notch2*, Receptors, Notch*, Amyloid Precursor Protein Secretases, Animals, Behavior, Animal, Disease Models, Animal, Epigenesis, Genetic, Female, GABAergic Neurons, Ganglionic Eminence, Humans, Interneurons, Male, Mice, Neurodevelopment, Signal Transduction, Vasoactive Intestinal Peptide (* major topic)
Topic: Neurogenesis and neuroplasticity mechanisms (Developmental Neuroscience, Neuroscience), according to OpenAlex
Funding: MEXT | Japan Society for the Promotion of Science (21K07327, 20K22913, 24K10716, 15K14355)
Citations: cited by 1 paper (Europe PMC); 70 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Code availability statement

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  • no repository, dataset or request procedure was recognized in it

Read it in the paper: doi.org/10.1038/s41467-026-70321-6.

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Data

Datasets cited

Code and data availability statement

The paper has a code and data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1038/s41467-026-70321-6.

Versions

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Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 14 authors, 4 keywords, 20 MeSH terms, 1 funder, 70 references.

Cite

This paper

Hanno, Y., Nakanishi, M., Takase, A., Nomura, J., Tanaka, M., Iida, Y., Tanaka, M., Hosokawa, H., Ito, M., Mikami, K., Hozumi, K., Miyoshi, G., Takumi, T., & Iijima, T. (2026). Targeting notch signaling to restore neural development and behavior in mouse models of ASD. Nature communications, 17(1), 2587. https://doi.org/10.1038/s41467-026-70321-6

BibTeX

@article{hanno2026targeting,
author = {Hanno, Yoko and Nakanishi, Moe and Takase, Akinori and Nomura, Jun and Tanaka, Masami and Iida, Yumi and Tanaka, Masayuki and Hosokawa, Hiroyuki and Ito, Masatoshi and Mikami, Katsunaka and Hozumi, Katsuto and Miyoshi, Goichi and Takumi, Toru and Iijima, Takatoshi},
title = {{Targeting notch signaling to restore neural development and behavior in mouse models of ASD}},
journal = {Nature communications},
year = {2026},
month = mar,
volume = {17},
number = {1},
pages = {2587},
publisher = {Nature Publishing Group},
issn = {2041-1723},
doi = {10.1038/s41467-026-70321-6},
url = {https://doi.org/10.1038/s41467-026-70321-6},
pmid = {41912527},
pmcid = {PMC13036009}
}

RIS

TY - JOUR
AU - Hanno, Yoko
AU - Nakanishi, Moe
AU - Takase, Akinori
AU - Nomura, Jun
AU - Tanaka, Masami
AU - Iida, Yumi
AU - Tanaka, Masayuki
AU - Hosokawa, Hiroyuki
AU - Ito, Masatoshi
AU - Mikami, Katsunaka
AU - Hozumi, Katsuto
AU - Miyoshi, Goichi
AU - Takumi, Toru
AU - Iijima, Takatoshi
TI - Targeting notch signaling to restore neural development and behavior in mouse models of ASD
T2 - Nature communications
J2 - Nat Commun
PY - 2026
DA - 2026/03/30
VL - 17
IS - 1
SP - 2587
SN - 2041-1723
PB - Nature Publishing Group
DO - 10.1038/s41467-026-70321-6
UR - https://doi.org/10.1038/s41467-026-70321-6
LA - en
ER -

CSL-JSON

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