OSCR

Structure of a pH-sensitive pentameric ligand-gated ion channel from the Sarcoptes scabies mite.

Overview

Authors: Jessica Kleiz-Ferreira1, Marijke Brams1, Peter J. Harrison2, Casey I. Gallagher1, Mieke Nys1, Ysaline Donze3, Andrew Quigley2, Daniel Bertrand3, Chris Ulens1
ORCID iDs: Jessica Kleiz-Ferreira, Marijke Brams, Mieke Nys, Ysaline Donze, Andrew Quigley, Daniel Bertrand, Chris Ulens
  1. Laboratory of Structural Neurobiology, Department of Cellular and Molecular Medicine, Faculty of Medicine, KU Leuven,Leuven, Belgium
  2. Membrane Protein Laboratory, Diamond Light Source, Research Complex at Harwell,Didcot, UK
  3. HiQscreen, 1222 Vésenaz,Geneva, Switzerland
Institutions: KU Leuven (Belgium); Research Complex at Harwell (United Kingdom); HiQScreen (Switzerland) (Switzerland)
Journal: Nature communications, volume 17, issue 1, article 3392
Dates: received 19 June 2025; accepted 27 February 2026; published online 13 March 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41467-026-70575-0 · PMID 41820392 · PMCID PMC13065796 · OpenAlex W7135068525
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: histology / microscopy (modality), cellular / molecular (subfield)
Methods: Connectivity, Evoked potentials
Keywords: Cryoelectron microscopy, Ion channels in the nervous system, Ligand-gated ion channels, Ion transport
MeSH: Antiparasitic Agents*, Ivermectin*, Ligand-Gated Ion Channels*, Sarcoptes scabiei*, Animals, Cryoelectron Microscopy, Ion Channel Gating, Protein Structure, Quaternary (* major topic)
Topic: Dermatological diseases and infestations (Infectious Diseases, Medicine), according to OpenAlex
Funding: Wellcome Trust (223727/Z/21/Z)
Citations: cited by 1 paper (Europe PMC); 73 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

The paper links to its data, not to its authors' code: see the Data section.

The paper's code and data availability statement is in the Data section.

Tracing map

A tracing map links a paper to the code its authors published: this paper has none, so it has no map.

Data

Datasets cited

Code and data availability statement

The paper has a code and data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1038/s41467-026-70575-0.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 9 authors, 4 keywords, 8 MeSH terms, 1 funder, 71 references.

Cite

This paper

Kleiz-Ferreira, J., Brams, M., Harrison, P. J., Gallagher, C. I., Nys, M., Donze, Y., Quigley, A., Bertrand, D., & Ulens, C. (2026). Structure of a pH-sensitive pentameric ligand-gated ion channel from the Sarcoptes scabies mite. Nature communications, 17(1), 3392. https://doi.org/10.1038/s41467-026-70575-0

BibTeX

@article{kleizferreira2026structure,
author = {Kleiz-Ferreira, Jessica and Brams, Marijke and Harrison, Peter J. and Gallagher, Casey I. and Nys, Mieke and Donze, Ysaline and Quigley, Andrew and Bertrand, Daniel and Ulens, Chris},
title = {{Structure of a pH-sensitive pentameric ligand-gated ion channel from the Sarcoptes scabies mite}},
journal = {Nature communications},
year = {2026},
month = mar,
volume = {17},
number = {1},
pages = {3392},
publisher = {Nature Publishing Group},
issn = {2041-1723},
doi = {10.1038/s41467-026-70575-0},
url = {https://doi.org/10.1038/s41467-026-70575-0},
pmid = {41820392},
pmcid = {PMC13065796}
}

RIS

TY - JOUR
AU - Kleiz-Ferreira, Jessica
AU - Brams, Marijke
AU - Harrison, Peter J.
AU - Gallagher, Casey I.
AU - Nys, Mieke
AU - Donze, Ysaline
AU - Quigley, Andrew
AU - Bertrand, Daniel
AU - Ulens, Chris
TI - Structure of a pH-sensitive pentameric ligand-gated ion channel from the Sarcoptes scabies mite
T2 - Nature communications
J2 - Nat Commun
PY - 2026
DA - 2026/03/13
VL - 17
IS - 1
SP - 3392
SN - 2041-1723
PB - Nature Publishing Group
DO - 10.1038/s41467-026-70575-0
UR - https://doi.org/10.1038/s41467-026-70575-0
LA - en
ER -

CSL-JSON

{
"id": "10.1038/s41467-026-70575-0",
"type": "article-journal",
"title": "Structure of a pH-sensitive pentameric ligand-gated ion channel from the Sarcoptes scabies mite",
"container-title": "Nature communications",
"author": [
{
"family": "Kleiz-Ferreira",
"given": "Jessica"
},
{
"family": "Brams",
"given": "Marijke"
},
{
"family": "Harrison",
"given": "Peter J."
},
{
"family": "Gallagher",
"given": "Casey I."
},
{
"family": "Nys",
"given": "Mieke"
},
{
"family": "Donze",
"given": "Ysaline"
},
{
"family": "Quigley",
"given": "Andrew"
},
{
"family": "Bertrand",
"given": "Daniel"
},
{
"family": "Ulens",
"given": "Chris"
}
],
"container-title-short": "Nat Commun",
"volume": "17",
"issue": "1",
"page": "3392",
"DOI": "10.1038/s41467-026-70575-0",
"PMID": "41820392",
"PMCID": "PMC13065796",
"ISSN": "2041-1723",
"publisher": "Nature Publishing Group",
"URL": "https://doi.org/10.1038/s41467-026-70575-0",
"language": "en",
"issued": {
"date-parts": [
[
2026,
3,
13
]
]
}
}

Similar papers

The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.

[1] doi:10.1038/s41467-026-71629-z
Extracellular K<sup>+</sup> modulates the pore conformations of Cys-loop receptor anion channels.
Journal: Nature communications
In common: cellular / molecular, 9 references
[2] doi:10.1038/s41467-026-76831-7
Structural origins of species-specific differences in TRPV2 activation.
Journal: Nature communications
In common: ebi.ac.uk/pdbe/entry, histology / microscopy, cellular / molecular, 6 references
[3] doi:10.1038/s41467-026-74814-2
Structural mechanism of Necrocide 1 activation of human TRPM4 that triggers necrosis by sodium overload.
Journal: Nature communications
In common: ebi.ac.uk/pdbe/entry, histology / microscopy, cellular / molecular, 6 references
[4] doi:10.1038/s41467-026-75444-4 [code]
Structural insights enable drug discovery for the neuronal NBCn2 carbonate transporter.
Journal: Nature communications
In common: ebi.ac.uk/pdbe/entry, histology / microscopy, cellular / molecular, 6 references
[5] doi:10.1038/s41467-026-75564-x
Cooperative mechanism of neurotransmitter recognition and transport by the human vesicular polyamine transporter.
Journal: Nature communications
In common: ebi.ac.uk/pdbe/entry, histology / microscopy, cellular / molecular, 5 references
[6] doi:10.1085/jgp.202513926
Characterization of an open-channel structure and lateral conduction pathway in the cation-selective pentameric ligand-gated ion channel, ELIC.
Journal: The Journal of general physiology
In common: cellular / molecular, 7 references
[7] doi:10.1038/s41594-026-01845-0
Conformational plasticity of human acid-sensing ion channel 1a.
Journal: Nature structural & molecular biology
In common: ebi.ac.uk/pdbe/entry, histology / microscopy, cellular / molecular, 5 references
[8] doi:10.1038/s41467-026-72780-3
Structural basis for the transport mechanism and cholesterol modulation of the human proline transporter.
Journal: Nature communications
In common: ebi.ac.uk/pdbe/entry, histology / microscopy, cellular / molecular, 5 references
[9] doi:10.1038/s41467-026-74087-9 [code]
Cryo-EM structures of heteromeric Kir4.1/5.1 channel suggest mechanisms of inward rectification and channel blockage.
Journal: Nature communications
In common: ebi.ac.uk/pdbe/entry, histology / microscopy, cellular / molecular, 4 references
[10] doi:10.1038/s41467-026-75941-6
Structural and functional studies of inward rectifier Kir7.1 and its regulation by the Melanocortin-4 receptor.
Journal: Nature communications
In common: ebi.ac.uk/pdbe/entry, histology / microscopy, cellular / molecular, 4 references

Contribute

The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.

Sign in with ORCID to claim this paper as one of its authors, correct its record or validate its tracing map: when the paper's metadata lists your ORCID iD, you are recognized at once. Maintainers of its code: sign in with GitHub, then claim the repository on your account page.

Request its removal

To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).

Discussion, reproductions, activity

Discussion: questions and error reports about this paper and its code, from signed-in readers and its authors. It opens with sign-in.

Reproductions: reports from readers who ran the authors' code: what they reproduced, with which environment, commit and data. It opens with sign-in.

Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.