OSCR

Functional and structural basis of a negative allostery within GABA<sub>B</sub> hetero-tetramers.

Overview

Authors: Cangsong Shen1,2, Hongyang Ding1,2, Shenlan Zhang2, Chanjuan Xu1,2, Binqian Zou3,4, Suyu Ji5, Yi-Ru Liu1,2, Yizhong Li1,2, Rui Zhou1,2, Jiayin Liang3,4, Dan-dan Shen5, Yuxuan Liu1, Xuan Chen1, Philippe Rondard6, Jun He3,4, Yan Zhang5, Jean-Philippe Pin6, Jianfeng Liu1,2
ORCID iDs: Chanjuan Xu, Yi-Ru Liu, Yuxuan Liu, Philippe Rondard, Jun He, Yan Zhang, Jean-Philippe Pin, Jianfeng Liu
  1. Key Laboratory of Molecular Biophysics of MOE, International Research Center for Sensory Biology and Technology of MOST, College of Life Science and Technology, Huazhong University of Science and Technology (HUST),Wuhan, China
  2. Bioland Laboratory, Guangzhou Regenerative Medicine and Health Guangdong Laboratory,Guangzhou, China
  3. State Key Laboratory of Respiratory Disease, Center for Biomedical Digital Science, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, GIBH-CUHK Joint Research Laboratory on Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences,Guangzhou, China
  4. State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University,Guangzhou, China
  5. Department of Pathology of Sir Run Run Shaw Hospital, Department of Pharmacology, MOE Frontier Science Center for Brain Research and Brain-Machine Integration, and Liangzhu Laboratory, Zhejiang University School of Medicine,Hangzhou, China
  6. Institut de Génomique Fonctionnelle (IGF), University of Montpellier, CNRS, INSERM,Montpellier, France
Institutions: Huazhong University of Science and Technology (China); Guangzhou Regenerative Medicine and Health Guangdong Laboratory (China); Chinese Academy of Sciences (China); First Affiliated Hospital of Guangzhou Medical University (China); Sir Run Run Shaw Hospital (China); Université de Montpellier (France)
Journal: Nature communications, volume 17, issue 1, article 4284
Dates: received 25 July 2025; accepted 24 February 2026; published online 20 March 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41467-026-70640-8 · PMID 41862465 · PMCID PMC13168656 · OpenAlex W7139918398
Open access: gold, a free copy (OpenAlex)
Status: data only (how the code is found and verified)
Categories: histology / microscopy (modality), human (organism), cellular / molecular (subfield)
Methods: Spectral & time-frequency, Statistics, fMRI & imaging
Keywords: Cryoelectron microscopy, Molecular neuroscience, G protein-coupled receptors, Molecular conformation
MeSH: Protein Multimerization*, Receptors, GABA-B*, Allosteric Regulation, Animals, Baclofen, Cryoelectron Microscopy, gamma-Aminobutyric Acid, HEK293 Cells, Humans, Models, Molecular, Mutation, Neurons (* major topic)
Topic: Nicotinic Acetylcholine Receptors Study (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: fondation recherche médicale - EQU202303016470
Citations: not cited yet (Europe PMC); 81 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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The paper's code and data availability statement is in the Data section.

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Data

Datasets cited

Code and data availability statement

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Read it in the paper: doi.org/10.1038/s41467-026-70640-8.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 18 authors, 4 keywords, 12 MeSH terms, 1 funder, 81 references.

Cite

This paper

Shen, C., Ding, H., Zhang, S., Xu, C., Zou, B., Ji, S., Liu, Y.-R., Li, Y., Zhou, R., Liang, J., Shen, D.-d., Liu, Y., Chen, X., Rondard, P., He, J., Zhang, Y., Pin, J.-P., & Liu, J. (2026). Functional and structural basis of a negative allostery within GABA<sub>B</sub> hetero-tetramers. Nature communications, 17(1), 4284. https://doi.org/10.1038/s41467-026-70640-8

BibTeX

@article{shen2026functional,
author = {Shen, Cangsong and Ding, Hongyang and Zhang, Shenlan and Xu, Chanjuan and Zou, Binqian and Ji, Suyu and Liu, Yi-Ru and Li, Yizhong and Zhou, Rui and Liang, Jiayin and Shen, Dan-dan and Liu, Yuxuan and Chen, Xuan and Rondard, Philippe and He, Jun and Zhang, Yan and Pin, Jean-Philippe and Liu, Jianfeng},
title = {{Functional and structural basis of a negative allostery within GABA\<sub\>B\</sub\> hetero-tetramers}},
journal = {Nature communications},
year = {2026},
month = mar,
volume = {17},
number = {1},
pages = {4284},
publisher = {Nature Publishing Group},
issn = {2041-1723},
doi = {10.1038/s41467-026-70640-8},
url = {https://doi.org/10.1038/s41467-026-70640-8},
pmid = {41862465},
pmcid = {PMC13168656}
}

RIS

TY - JOUR
AU - Shen, Cangsong
AU - Ding, Hongyang
AU - Zhang, Shenlan
AU - Xu, Chanjuan
AU - Zou, Binqian
AU - Ji, Suyu
AU - Liu, Yi-Ru
AU - Li, Yizhong
AU - Zhou, Rui
AU - Liang, Jiayin
AU - Shen, Dan-dan
AU - Liu, Yuxuan
AU - Chen, Xuan
AU - Rondard, Philippe
AU - He, Jun
AU - Zhang, Yan
AU - Pin, Jean-Philippe
AU - Liu, Jianfeng
TI - Functional and structural basis of a negative allostery within GABA<sub>B</sub> hetero-tetramers
T2 - Nature communications
J2 - Nat Commun
PY - 2026
DA - 2026/03/20
VL - 17
IS - 1
SP - 4284
SN - 2041-1723
PB - Nature Publishing Group
DO - 10.1038/s41467-026-70640-8
UR - https://doi.org/10.1038/s41467-026-70640-8
LA - en
ER -

CSL-JSON

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"language": "en",
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