Auxiliary subunits reshape structural asymmetry and functional plasticity in heterotetrameric GluA1/A2 AMPA receptor core.
Overview
- Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY USA
- Cellular and Molecular Physiology and Biophysics Graduate Program, Columbia University Irving Medical Center, New York, NY USA
- Cellular, Molecular, and Biomedical Studies Umbrella Program, Columbia University Irving Medical Center, New York, NY USA
- Department of Chemistry, Carnegie Mellon University, Pittsburgh, PA USA
- Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark
Abstract
AMPA-subtype ionotropic glutamate receptors (AMPARs) mediate the fast component of excitatory neurotransmission. They govern synaptic plasticity that underlies learning and memory, while their dysregulation is implicated in numerous neurological disorders. The functional diversity of AMPARs arises from variations in their subunit composition and also their association with auxiliary subunits. While multiple structures of homomeric AMPARs have been reported, structural information for the heteromeric core – particularly in the absence of auxiliary subunits, which would serve as a functional and structural baseline – has been limited. Here, we report cryo-electron microscopy structures of GluA1/
Reproduced under the paper's license (CC BY), from the paper cited above.
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Data
Datasets cited
- ebi.ac.uk/
pdbe/ , at EMBL-EBI; found in “Data availability”entry - figshare:30015367, at figshare; found in DataCite
Data availability
The cryo-EM density maps have been deposited to the Electron Microscopy Data Bank (EMDB) under the accession codes EMD-70909 (https://
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
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Version 1, 30 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 8 authors, 3 keywords, 8 MeSH terms, 7 funders, 106 references.
Cite
This paper
Yen, L. Y., Newton, T. P., Yelshanskaya, M. V., Aktolun, M., Gangwar, S. P., Clausen, R. P., Kurnikova, M. G., & Sobolevsky, A. I. (2026). Auxiliary subunits reshape structural asymmetry and functional plasticity in heterotetrameric GluA1/
BibTeX
@article{yen2026auxiliar
author = {Yen, Laura Y and Newton, Thomas P and Yelshanskaya, Maria V and Aktolun, Muhammed and Gangwar, Shanti Pal and Clausen, Rasmus P and Kurnikova, Maria G and Sobolevsky, Alexander I},
title = {{Auxiliary subunits reshape structural asymmetry and functional plasticity in heterotetrameric GluA1/
journal = {Nature communications},
year = {2026},
month = mar,
volume = {17},
number = {1},
pages = {4191},
publisher = {Nature Publishing Group},
issn = {2041-1723},
doi = {10.1038/
url = {https://
pmid = {41904128},
pmcid = {PMC13153358}
}
RIS
TY - JOUR
AU - Yen, Laura Y
AU - Newton, Thomas P
AU - Yelshanskaya, Maria V
AU - Aktolun, Muhammed
AU - Gangwar, Shanti Pal
AU - Clausen, Rasmus P
AU - Kurnikova, Maria G
AU - Sobolevsky, Alexander I
TI - Auxiliary subunits reshape structural asymmetry and functional plasticity in heterotetrameric GluA1/
T2 - Nature communications
J2 - Nat Commun
PY - 2026
DA - 2026/
VL - 17
IS - 1
SP - 4191
SN - 2041-1723
PB - Nature Publishing Group
DO - 10.1038/
UR - https://
LA - en
ER -
CSL-JSON
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"language": "en",
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