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Polymersomes preventing brain infiltration of CD177<sup>+</sup> neutrophils to mitigate hemorrhagic transformation post-tPA thrombolysis.

Overview

Authors: Zhenhua Wang1, Hua Liu2, Zhiyao Xu2, Cheng Huang1, Xing Guo1, Shaobing Zhou1
ORCID iDs: Xing Guo, Shaobing Zhou
  1. Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University,Chengdu, PR China
  2. Department of Neurology, The Third People’s Hospital of Chengdu,Chengdu, PR China
Institutions: Southwest Jiaotong University (China); Third People's Hospital of Chengdu (China)
Journal: Nature communications, volume 17, issue 1, article 4395
Dates: received 5 June 2025; accepted 12 March 2026; published online 25 March 2026
Type: Research article · Language: English
License: CC BY
Identifiers: DOI 10.1038/s41467-026-71076-w · PMID 41881994 · PMCID PMC13181025 · OpenAlex W7140285352
Open access: gold, a free copy (OpenAlex)
Status: data only (how the code is found and verified)
Categories: human (organism), mouse (organism), stroke (population)
Methods: Statistics, Smoothing, state filtering, decompositions, Machine learning
Keywords: Drug delivery, Coagulation system
MeSH: Fibrinolytic Agents*, Hemorrhagic Stroke*, Neutrophils*, Thrombolytic Therapy*, Tissue Plasminogen Activator*, Animals, Brain, Cell Line, Cerebral Hemorrhage, GPI-Linked Proteins, Humans, Isoantigens, Male, Mice, Mice, Inbred C57BL, Polymers, Reactive Oxygen Species, Receptors, Cell Surface, Recombinant Proteins (* major topic)
Topic: Neutrophil, Myeloperoxidase and Oxidative Mechanisms (Immunology, Immunology and Microbiology), according to OpenAlex
Funding: National Natural Science Foundation of China (U22A20161, 52495011, 52473324)
Citations: not cited yet (Europe PMC); 75 references in the paper

Abstract

As an intravenous thrombolytic agent, tissue plasminogen activator (tPA) is limited by hemorrhagic transformation (HT) and a narrow therapeutic time window. Here we develop ROS-triggered polymersomes conjugated with fibrin-targeting CREKA peptide (CP) for tPA encapsulation. achieves efficient thrombosis targeting and enhanced thrombolytic efficacy, however, it has not been able to avert the occurrence of hemorrhage subsequent to thrombolysis. Building from our clinical discovery that stroke patients suffer from tPA-induced HT featured strong expression of CD177, recombinant CD177 protein (rCD177) was loaded into CP polymersomes as nanomedicine and administrated prior to thrombolysis. rCD177 can be released in response to elevated ROS within the obstructed vessels, which binds to endothelial cells through interacting with CD31 and efficiently prevents the migration of CD177+ neutrophils into the brain parenchyma. The reduced CD177+ neutrophils suppress the generation of neutrophil extracellular traps (NETs), thereby dampening the inflammatory activation of microglia and ultimately improving the prognosis of HT. This innovative strategy presents a promising avenue for attenuating hemorrhagic complications post-thrombolysis

Reproduced under the paper's license (CC BY), from the paper cited above.

Code

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Data

Datasets cited

Data availability

All data supporting the results of this study are included in the article and Supplementary Information. The RNA-seq has been deposited to NCBI under accession codes (PRJNA1331951 (https://www.ncbi.nlm.nih.gov/bioproject/PRJNA1331951), PRJNA1332825 (https://www.ncbi.nlm.nih.gov/bioproject/?term=PRJNA1332825)). Source data are provided with this paper.

Reproduced under the paper's license (CC BY), from the paper cited above.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 6 authors, 2 keywords, 19 MeSH terms, 1 funder, 74 references.

Cite

This paper

Wang, Z., Liu, H., Xu, Z., Huang, C., Guo, X., & Zhou, S. (2026). Polymersomes preventing brain infiltration of CD177<sup>+</sup> neutrophils to mitigate hemorrhagic transformation post-tPA thrombolysis. Nature communications, 17(1), 4395. https://doi.org/10.1038/s41467-026-71076-w

BibTeX

@article{wang2026polymersomes,
author = {Wang, Zhenhua and Liu, Hua and Xu, Zhiyao and Huang, Cheng and Guo, Xing and Zhou, Shaobing},
title = {{Polymersomes preventing brain infiltration of CD177\<sup\>+\</sup\> neutrophils to mitigate hemorrhagic transformation post-tPA thrombolysis}},
journal = {Nature communications},
year = {2026},
month = mar,
volume = {17},
number = {1},
pages = {4395},
publisher = {Nature Publishing Group},
issn = {2041-1723},
doi = {10.1038/s41467-026-71076-w},
url = {https://doi.org/10.1038/s41467-026-71076-w},
pmid = {41881994},
pmcid = {PMC13181025}
}

RIS

TY - JOUR
AU - Wang, Zhenhua
AU - Liu, Hua
AU - Xu, Zhiyao
AU - Huang, Cheng
AU - Guo, Xing
AU - Zhou, Shaobing
TI - Polymersomes preventing brain infiltration of CD177<sup>+</sup> neutrophils to mitigate hemorrhagic transformation post-tPA thrombolysis
T2 - Nature communications
J2 - Nat Commun
PY - 2026
DA - 2026/03/25
VL - 17
IS - 1
SP - 4395
SN - 2041-1723
PB - Nature Publishing Group
DO - 10.1038/s41467-026-71076-w
UR - https://doi.org/10.1038/s41467-026-71076-w
LA - en
ER -

CSL-JSON

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"language": "en",
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