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Sustained visceral fat loss is associated with attenuated brain atrophy and improved cognitive function in late midlife.

Overview

Authors: Dafna Pachter1, Hadar Klein1, Omer Kamer1, Dana Tamar Goldberg Toren1, Liav Alufer1, Noa Ebstein Karamani1, Tomer Atlas1, Amit Yaary1, Idan Hagbi1, Yoash Chassidim2, Ilan Shelef3, Moti Salti4, Frauke Beyer5, Veronica Witte5, Assaf Rudich6, Uri Yoel3,7, Gal Ben-Arie3, Anat Yaskolka Meir1, Alon Kaplan1, Gal Tsaban1
and 12 other authorsHila Zelicha1, Carmi Bartal8, Lu Qi9,10, Matthias Blüher11, Michael Stumvoll12, Uta Ceglarek13, Berend Isermann13, Dong D Wang10, Meir J Stampfer10, Frank B Hu10, Galia Avidan4,14, Iris Shai1,10,12,15
ORCID iDs: Hadar Klein, Moti Salti, Frauke Beyer, Veronica Witte, Assaf Rudich, Uri Yoel, Anat Yaskolka Meir, Lu Qi, Matthias Blüher, Michael Stumvoll, Berend Isermann, Dong D Wang, Galia Avidan, Iris Shai
15 affiliations
  1. The Health & Nutrition Innovative International Research Center, Department of Epidemiology, Biostatistics and Community Health Sciences, Faculty of Health Sciences, School of Public Health, Ben-Gurion University of the Negev, Beer-Sheva, Israel
  2. Department of Engineering, Sapir Academic College, Shaar Hanegev, Israel
  3. Soroka University Medical Center, Beer-Sheva, Israel
  4. Department of Psychology, Ben-Gurion University of the Negev, Beer-Sheva, Israel
  5. Department of Neurology, Max-Planck-Institute for Human Cognitive and Brain Sciences, and Cognitive Neurology, University of Leipzig Medical Center, Leipzig, Stephanstraße, Leipzig, Germany
  6. Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
  7. Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
  8. Briuta Care Medical Center, Beer-Sheva, Israel
  9. Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA USA
  10. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA USA
  11. Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany
  12. Department of Medicine, University of Leipzig, Leipzig, Germany
  13. University of Leipzig Medical Center, Institute of Laboratory Medicine, Leipzig, Germany
  14. Department of Cognitive and Brain Sciences and The School of Brain Sciences and Cognition, Ben-Gurion University of the Negev, Beer-Sheva, Israel
  15. School of Sustainability, Reichman University, Herzliya, Israel
Institutions: Ben-Gurion University of the Negev (Israel); Sapir College (Israel); Soroka Medical Center (Israel); University Hospital Leipzig (Germany); Max Planck Institute for Human Cognitive and Brain Sciences (Germany); Leipzig University (Germany); Mayanei Hayeshua Medical Center (Israel); Tulane University (United States); Harvard University (United States); Helmholtz Munich (Germany); Reichman University (Israel)
Journal: Nature communications, volume 17, issue 1, article 4434
Dates: received 22 July 2025; accepted 4 March 2026; published online 26 March 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41467-026-71141-4 · PMID 41888134 · PMCID PMC13183986 · OpenAlex W7140479990
Open access: gold, a free copy (OpenAlex)
Status: code on request (how the code is found and verified)
Categories: structural MRI / diffusion (modality), human (organism)
Methods: Statistics, Preprocessing, Machine learning
Keywords: Predictive markers
MeSH: Brain*, Cognition*, Intra-Abdominal Fat*, Aged, Atrophy, Female, Humans, Life Style, Magnetic Resonance Imaging, Male, Middle Aged, Randomized Controlled Trials as Topic, Weight Loss (* major topic)
Topic: Advanced Neuroimaging Techniques and Applications (Radiology, Nuclear Medicine and Imaging, Medicine), according to OpenAlex
Funding: Deutsche Forschungsgemeinschaft (SFB 1052, 209933838, SFB-1052/B11, 533765739); Ben-Gurion University of the Negev
Citations: cited by 2 papers (Europe PMC); 54 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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The paper's code and data availability statement is in the Data section.

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Data

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Code and data availability statement

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Read it in the paper: doi.org/10.1038/s41467-026-71141-4.

Versions

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Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 32 authors, 1 keyword, 13 MeSH terms, 2 funders, 43 references.

Cite

This paper

Pachter, D., Klein, H., Kamer, O., Goldberg Toren, D. T., Alufer, L., Ebstein Karamani, N., Atlas, T., Yaary, A., Hagbi, I., Chassidim, Y., Shelef, I., Salti, M., Beyer, F., Witte, V., Rudich, A., Yoel, U., Ben-Arie, G., Yaskolka Meir, A., Kaplan, A., . . . Shai, I. (2026). Sustained visceral fat loss is associated with attenuated brain atrophy and improved cognitive function in late midlife. Nature communications, 17(1), 4434. https://doi.org/10.1038/s41467-026-71141-4

BibTeX

@article{pachter2026sustained,
author = {Pachter, Dafna and Klein, Hadar and Kamer, Omer and Goldberg Toren, Dana Tamar and Alufer, Liav and Ebstein Karamani, Noa and Atlas, Tomer and Yaary, Amit and Hagbi, Idan and Chassidim, Yoash and Shelef, Ilan and Salti, Moti and Beyer, Frauke and Witte, Veronica and Rudich, Assaf and Yoel, Uri and Ben-Arie, Gal and Yaskolka Meir, Anat and Kaplan, Alon and Tsaban, Gal and Zelicha, Hila and Bartal, Carmi and Qi, Lu and Blüher, Matthias and Stumvoll, Michael and Ceglarek, Uta and Isermann, Berend and Wang, Dong D and Stampfer, Meir J and Hu, Frank B and Avidan, Galia and Shai, Iris},
title = {{Sustained visceral fat loss is associated with attenuated brain atrophy and improved cognitive function in late midlife}},
journal = {Nature communications},
year = {2026},
month = mar,
volume = {17},
number = {1},
pages = {4434},
publisher = {Nature Publishing Group},
issn = {2041-1723},
doi = {10.1038/s41467-026-71141-4},
url = {https://doi.org/10.1038/s41467-026-71141-4},
pmid = {41888134},
pmcid = {PMC13183986}
}

RIS

TY - JOUR
AU - Pachter, Dafna
AU - Klein, Hadar
AU - Kamer, Omer
AU - Goldberg Toren, Dana Tamar
AU - Alufer, Liav
AU - Ebstein Karamani, Noa
AU - Atlas, Tomer
AU - Yaary, Amit
AU - Hagbi, Idan
AU - Chassidim, Yoash
AU - Shelef, Ilan
AU - Salti, Moti
AU - Beyer, Frauke
AU - Witte, Veronica
AU - Rudich, Assaf
AU - Yoel, Uri
AU - Ben-Arie, Gal
AU - Yaskolka Meir, Anat
AU - Kaplan, Alon
AU - Tsaban, Gal
AU - Zelicha, Hila
AU - Bartal, Carmi
AU - Qi, Lu
AU - Blüher, Matthias
AU - Stumvoll, Michael
AU - Ceglarek, Uta
AU - Isermann, Berend
AU - Wang, Dong D
AU - Stampfer, Meir J
AU - Hu, Frank B
AU - Avidan, Galia
AU - Shai, Iris
TI - Sustained visceral fat loss is associated with attenuated brain atrophy and improved cognitive function in late midlife
T2 - Nature communications
J2 - Nat Commun
PY - 2026
DA - 2026/03/26
VL - 17
IS - 1
SP - 4434
SN - 2041-1723
PB - Nature Publishing Group
DO - 10.1038/s41467-026-71141-4
UR - https://doi.org/10.1038/s41467-026-71141-4
LA - en
ER -

CSL-JSON

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"issued": {
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}

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