OSCR

Dysregulation of macrophage lipid metabolism underlies intracellular bacterial neuroinvasion.

Overview

Authors: Zhou Sha1, Kun Yang2, Shoupeng Fu3, Xiaoyong Tong4, Hui Yang1, Huiling Fang1, Qianqian He1, Ning Li5,6, Xinyu Shu5,6, Qi Liu1, Beibei Fu1, Jin Liu4, Qian Li7, Hao Zeng8, Xiaokai Zhang8, Rui Yao9, Xushuo Zhang10, Wenjin Guo3, Xuhu Mao7, Mian Long5,6, Xiaoyuan Lin7,11, Quanming Zou8, Haibo Wu1
ORCID iDs: Qian Li, Xiaokai Zhang, Xuhu Mao, Mian Long, Quanming Zou, Haibo Wu
  1. School of Life Sciences, Chongqing University, Chongqing, China
  2. Chongqing Public Health Medical Center, Chongqing, China
  3. School of Veterinary Medicine, Jilin University, Changchun, China
  4. School of Pharmaceutical Sciences, Chongqing University, Chongqing, China
  5. Center of Biomechanics and Bioengineering, Key Laboratory of Microgravity (National Microgravity Laboratory), Beijing Key Laboratory of Engineered Construction and Mechanobiology, Institute of Mechanics, Chinese Academy of Sciences, Beijing, China
  6. School of Engineering Sciences, University of Chinese Academy of Sciences, Beijing, China
  7. Department of Clinical Microbiology and Immunology, College of Pharmacy and Laboratory Medicine, Army Medical University (Third Military Medical University), Chongqing, China
  8. National Engineering Research Center of Immunological, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy and Laboratory Medicine, Army Medical University (Third Military Medical University), Chongqing, China
  9. Department of Pathology, Chongqing Hygeia Hospital, Chongqing, China
  10. Zhejiang Toyouvax Biopharming, Hangzhou, China
  11. Institut für Virologie, Freie Universität Berlin, Berlin, Germany
Institutions: Chongqing University (China); Chongqing Public Health Medical Center (China); Jilin University (China); Chinese Academy of Sciences (China); Institute of Mechanics (China); University of Chinese Academy of Sciences (China); Army Medical University (China); Freie Universität Berlin (Germany)
Journal: Nature communications, volume 17, issue 1, article 5202
Dates: received 15 July 2025; accepted 25 March 2026; published online 14 April 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41467-026-71791-4 · PMID 41980980 · PMCID PMC13253848 · OpenAlex W4392291920
Open access: gold, a free copy (OpenAlex)
Preprint: doi:10.1101/2024.02.28.582462
Status: data only
Categories: mouse (organism), cellular / molecular (subfield)
Methods: Statistics, Smoothing, state filtering, decompositions, Connectivity, Machine learning
Keywords: Monocytes and macrophages, Bacterial host response, Neuroimmunology, Glycolipids
MeSH: Brain*, Central Nervous System Infections*, Lipid Metabolism*, Macrophages*, 3-Hydroxybutyric Acid, Animals, Blood-Brain Barrier, CD36 Antigens, Fatty Acid-Binding Proteins, Glucose, Mice, Mice, Inbred C57BL, PPAR gamma (* major topic)
Topic: Diet and metabolism studies (Physiology, Medicine), according to OpenAlex
Funding: National Natural Science Foundation of China (92469110, 92369115, 82422048); Natural Science Foundation of Chongqing (CSTB2023NSCQMSX0402)
Citations: cited by 1 paper (Europe PMC); 66 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

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Read it in the paper: doi.org/10.1038/s41467-026-71791-4.

Versions

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Version 1, 29 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 23 authors, 4 keywords, 13 MeSH terms, 2 funders, 65 references.

Cite

This paper

Sha, Z., Yang, K., Fu, S., Tong, X., Yang, H., Fang, H., He, Q., Li, N., Shu, X., Liu, Q., Fu, B., Liu, J., Li, Q., Zeng, H., Zhang, X., Yao, R., Zhang, X., Guo, W., Mao, X., . . . Wu, H. (2026). Dysregulation of macrophage lipid metabolism underlies intracellular bacterial neuroinvasion. Nature communications, 17(1), 5202. https://doi.org/10.1038/s41467-026-71791-4

BibTeX

@article{sha2026dysregulation,
author = {Sha, Zhou and Yang, Kun and Fu, Shoupeng and Tong, Xiaoyong and Yang, Hui and Fang, Huiling and He, Qianqian and Li, Ning and Shu, Xinyu and Liu, Qi and Fu, Beibei and Liu, Jin and Li, Qian and Zeng, Hao and Zhang, Xiaokai and Yao, Rui and Zhang, Xushuo and Guo, Wenjin and Mao, Xuhu and Long, Mian and Lin, Xiaoyuan and Zou, Quanming and Wu, Haibo},
title = {{Dysregulation of macrophage lipid metabolism underlies intracellular bacterial neuroinvasion}},
journal = {Nature communications},
year = {2026},
month = apr,
volume = {17},
number = {1},
pages = {5202},
publisher = {Nature Publishing Group},
issn = {2041-1723},
doi = {10.1038/s41467-026-71791-4},
url = {https://doi.org/10.1038/s41467-026-71791-4},
pmid = {41980980},
pmcid = {PMC13253848}
}

RIS

TY - JOUR
AU - Sha, Zhou
AU - Yang, Kun
AU - Fu, Shoupeng
AU - Tong, Xiaoyong
AU - Yang, Hui
AU - Fang, Huiling
AU - He, Qianqian
AU - Li, Ning
AU - Shu, Xinyu
AU - Liu, Qi
AU - Fu, Beibei
AU - Liu, Jin
AU - Li, Qian
AU - Zeng, Hao
AU - Zhang, Xiaokai
AU - Yao, Rui
AU - Zhang, Xushuo
AU - Guo, Wenjin
AU - Mao, Xuhu
AU - Long, Mian
AU - Lin, Xiaoyuan
AU - Zou, Quanming
AU - Wu, Haibo
TI - Dysregulation of macrophage lipid metabolism underlies intracellular bacterial neuroinvasion
T2 - Nature communications
J2 - Nat Commun
PY - 2026
DA - 2026/04/14
VL - 17
IS - 1
SP - 5202
SN - 2041-1723
PB - Nature Publishing Group
DO - 10.1038/s41467-026-71791-4
UR - https://doi.org/10.1038/s41467-026-71791-4
LA - en
ER -

CSL-JSON

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