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HuR coordinates systemic aging through platelet infiltration.

Overview

Authors: Cihang Liu1,2, Ying Wang2, Tianjiao Xia3, Jing Lin4, Qianzan Liao2, Yanyan Li5, Yiqiang Zhang5, Congxiu Miao5, Xia Yi2, Luyang Sun2, Zhengliang Ma1, Xiaolei Cheng1, Bin Jiang2, Feng Tian6, Zhenyu Ju7, Baohua Liu8, Wei Kong9, Yi Fu9, Zhongzhou Yang3, Junling Liu10, Hao Tang11, Xiaoping Gu1, Wengong Wang2,5,12
ORCID iDs: Congxiu Miao, Luyang Sun, Xiaolei Cheng, Bin Jiang, Zhenyu Ju, Baohua Liu, Wei Kong, Yi Fu, Zhongzhou Yang, Junling Liu, Hao Tang, Xiaoping Gu, Wengong Wang
  1. Department of Anesthesiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University,Nanjing, China
  2. Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center,Beijing, China
  3. State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Key Laboratory of Molecular Medicine, Medical School, Nanjing University,Nanjing, China
  4. Department of laboratory medicine, the Fourth Medical Center, Chinese PLA General Hospital,Beijing, China
  5. Center for Healthy Aging, Changzhi Medical College,Changzhi, China
  6. Department of Laboratory Animal Science, Peking University Health Science Center,Beijing, China
  7. Key Laboratory of Regenerative Medicine of Ministry of Education, Institute of Aging and Regenerative Medicine, Jinan University,Guangzhou, China
  8. Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Shenzhen University Health Science Center,Shenzhen, China
  9. Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University,Beijing, China
  10. Department of Biochemistry and Molecular Cell Biology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine,Shanghai, China
  11. National Health Commission Key Laboratory of Cardiovascular Regenerative Medicine, Heart Center of Henan Provincial People’s Hospital, Central China Fuwai Hospital of Zhengzhou University, Central China Fuwai Hospital & Central China Branch of National Center for Cardiovascular Diseases,Henan Zhengzhou, China
  12. College of Basic Medical Science, Jinzhou Medical University,Jinzhou, China
Institutions: Nanjing University (China); Peking University (China); Chinese PLA General Hospital (China); Changzhi Medical College (China); Jinan University (China); Shenzhen University Health Science Center (China); Shanghai Jiao Tong University (China); Henan Provincial People's Hospital (China); Jinzhou Medical University (China)
Journal: Nature communications, volume 17, issue 1, article 6225
Dates: received 7 July 2025; accepted 13 April 2026; published online 7 May 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41467-026-72481-x · PMID 42098101 · PMCID PMC13370026 · OpenAlex W7160557441
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: mouse (organism), cellular / molecular (subfield)
Methods: Statistics, Smoothing, state filtering, decompositions, Evoked potentials, Connectivity, Machine learning
Keywords: RNA metabolism, Experimental models of disease, Stress signalling
MeSH: Aging*, Blood Platelets*, ELAV-Like Protein 1*, Animals, Brain, Inflammation, Kidney, Liver, Lung, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Signal Transduction, Tumor Suppressor Protein p53 (* major topic)
Topic: RNA Research and Splicing (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: National Natural Science Foundation of China (81930035, 92249303, 82230048, 91749208); Peking University; National Key Research and Development Program of China (2024YFA0918700, 92249303)
Citations: cited by 1 paper (Europe PMC); 53 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

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Data availability statement

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  • no repository, dataset or request procedure was recognized in it

Read it in the paper: doi.org/10.1038/s41467-026-72481-x.

Versions

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Version 2, 28 September 2026

  • Funding: added National Natural Science Foundation of China: 81930035, 92249303, 82230048, 91749208; Peking University; National Key Research and Development Program of China: 2024YFA0918700, 92249303

Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 23 authors, 3 keywords, 15 MeSH terms, 53 references.

Cite

This paper

Liu, C., Wang, Y., Xia, T., Lin, J., Liao, Q., Li, Y., Zhang, Y., Miao, C., Yi, X., Sun, L., Ma, Z., Cheng, X., Jiang, B., Tian, F., Ju, Z., Liu, B., Kong, W., Fu, Y., Yang, Z., . . . Wang, W. (2026). HuR coordinates systemic aging through platelet infiltration. Nature communications, 17(1), 6225. https://doi.org/10.1038/s41467-026-72481-x

BibTeX

@article{liu2026hur,
author = {Liu, Cihang and Wang, Ying and Xia, Tianjiao and Lin, Jing and Liao, Qianzan and Li, Yanyan and Zhang, Yiqiang and Miao, Congxiu and Yi, Xia and Sun, Luyang and Ma, Zhengliang and Cheng, Xiaolei and Jiang, Bin and Tian, Feng and Ju, Zhenyu and Liu, Baohua and Kong, Wei and Fu, Yi and Yang, Zhongzhou and Liu, Junling and Tang, Hao and Gu, Xiaoping and Wang, Wengong},
title = {{HuR coordinates systemic aging through platelet infiltration}},
journal = {Nature communications},
year = {2026},
month = may,
volume = {17},
number = {1},
pages = {6225},
publisher = {Nature Publishing Group},
issn = {2041-1723},
doi = {10.1038/s41467-026-72481-x},
url = {https://doi.org/10.1038/s41467-026-72481-x},
pmid = {42098101},
pmcid = {PMC13370026}
}

RIS

TY - JOUR
AU - Liu, Cihang
AU - Wang, Ying
AU - Xia, Tianjiao
AU - Lin, Jing
AU - Liao, Qianzan
AU - Li, Yanyan
AU - Zhang, Yiqiang
AU - Miao, Congxiu
AU - Yi, Xia
AU - Sun, Luyang
AU - Ma, Zhengliang
AU - Cheng, Xiaolei
AU - Jiang, Bin
AU - Tian, Feng
AU - Ju, Zhenyu
AU - Liu, Baohua
AU - Kong, Wei
AU - Fu, Yi
AU - Yang, Zhongzhou
AU - Liu, Junling
AU - Tang, Hao
AU - Gu, Xiaoping
AU - Wang, Wengong
TI - HuR coordinates systemic aging through platelet infiltration
T2 - Nature communications
J2 - Nat Commun
PY - 2026
DA - 2026/05/07
VL - 17
IS - 1
SP - 6225
SN - 2041-1723
PB - Nature Publishing Group
DO - 10.1038/s41467-026-72481-x
UR - https://doi.org/10.1038/s41467-026-72481-x
LA - en
ER -

CSL-JSON

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