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MeCP2 Governs maternal hyperandrogenism-induced cortical defects and behavioral alterations via noncanonical AR-dependent regulation of Mef2c.

Overview

Authors: Yu-Meng Wang1,2, Yanyan Jia3, Yu Wu4, Qiaohang Zhao5, Yumeng Guo6, Li Zhang1, Min Jin5, Yufang Zheng2
ORCID iDs: Yanyan Jia, Li Zhang, Min Jin, Yufang Zheng
  1. Department of Cardiology, Institute for Developmental and Regenerative Cardiovascular Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
  2. Obstetrics and Gynecology Hospital, The institute of Obstetrics and Gynecology, Shanghai key lab of reproduction and development, Shanghai key lab of female reproductive endocrine related diseases, Fudan University, Shanghai, China
  3. ENT Institute and Otorhinolaryngology Department of Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China
  4. Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China
  5. Department of Reproductive Medicine, the Second Affiliated Hospital, Medical School, Zhejiang University, Hangzhou, Zhejiang China
  6. Department of Digestive Diseases, Huashan Hospital, Fudan University, Shanghai, China
Institutions: Shanghai Medical College of Fudan University (China); Shanghai Jiao Tong University (China); Fudan University (China); XinHua Hospital (China); Obstetrics and Gynecology Hospital of Fudan University (China); Eye & ENT Hospital of Fudan University (China); State Key Laboratory of Medical Neurobiology; Frontiers Center for Brain Science of the Ministry of Education (China); Second Affiliated Hospital of Zhejiang University (China); Zhejiang University (China); Huashan Hospital (China)
Journal: Nature communications, volume 17, issue 1, article 4225
Dates: received 23 May 2025; accepted 27 April 2026; published online 13 May 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41467-026-72942-3 · PMID 42129177 · PMCID PMC13171901 · OpenAlex W7161012964
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: mouse (organism), developmental (subfield)
Methods: Statistics
Keywords: Neuronal development, Development of the nervous system, Neurogenesis
MeSH: Androgens*, Cerebral Cortex*, MEF2 Transcription Factors*, Methyl-CpG-Binding Protein 2*, Prenatal Exposure Delayed Effects*, Receptors, Androgen*, Animals, Behavior, Animal, Female, Male, Mice, Neurogenesis, Pregnancy (* major topic)
Topic: Genetics and Neurodevelopmental Disorders (Genetics, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: National Natural Science Foundation of China (National Science Foundation of China) (81901159)
Citations: cited by 1 paper (Europe PMC); 66 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Datasets cited

Code and data availability statement

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Versions

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Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 8 authors, 3 keywords, 13 MeSH terms, 1 funder, 66 references.

Cite

This paper

Wang, Y.-M., Jia, Y., Wu, Y., Zhao, Q., Guo, Y., Zhang, L., Jin, M., & Zheng, Y. (2026). MeCP2 Governs maternal hyperandrogenism-induced cortical defects and behavioral alterations via noncanonical AR-dependent regulation of Mef2c. Nature communications, 17(1), 4225. https://doi.org/10.1038/s41467-026-72942-3

BibTeX

@article{wang2026mecp2,
author = {Wang, Yu-Meng and Jia, Yanyan and Wu, Yu and Zhao, Qiaohang and Guo, Yumeng and Zhang, Li and Jin, Min and Zheng, Yufang},
title = {{MeCP2 Governs maternal hyperandrogenism-induced cortical defects and behavioral alterations via noncanonical AR-dependent regulation of Mef2c}},
journal = {Nature communications},
year = {2026},
month = may,
volume = {17},
number = {1},
pages = {4225},
publisher = {Nature Publishing Group},
issn = {2041-1723},
doi = {10.1038/s41467-026-72942-3},
url = {https://doi.org/10.1038/s41467-026-72942-3},
pmid = {42129177},
pmcid = {PMC13171901}
}

RIS

TY - JOUR
AU - Wang, Yu-Meng
AU - Jia, Yanyan
AU - Wu, Yu
AU - Zhao, Qiaohang
AU - Guo, Yumeng
AU - Zhang, Li
AU - Jin, Min
AU - Zheng, Yufang
TI - MeCP2 Governs maternal hyperandrogenism-induced cortical defects and behavioral alterations via noncanonical AR-dependent regulation of Mef2c
T2 - Nature communications
J2 - Nat Commun
PY - 2026
DA - 2026/05/13
VL - 17
IS - 1
SP - 4225
SN - 2041-1723
PB - Nature Publishing Group
DO - 10.1038/s41467-026-72942-3
UR - https://doi.org/10.1038/s41467-026-72942-3
LA - en
ER -

CSL-JSON

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"container-title": "Nature communications",
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"issue": "1",
"page": "4225",
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"PMID": "42129177",
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"ISSN": "2041-1723",
"publisher": "Nature Publishing Group",
"URL": "https://doi.org/10.1038/s41467-026-72942-3",
"language": "en",
"issued": {
"date-parts": [
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}

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