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Scg2 drives corticospinal circuit reorganization with spinal premotor interneurons and astrocytes for motor recovery after stroke in mice.

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Paper

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The authors' code

MATLAB · 32 lines · 1.2 KB · MIT

  1. cd("path"); %%% path meas the project directory %%%
  3. data = "Test_Sample.csv"; %%% select sample file %%%
  5. %%% Load file %%%
  6. newData = readmatrix(data);
  8. %%% Setting parameters %%%
  9. data_size = size(newData);
  10. samp_freq = 1000; %%% sampling_rate ex) 1000 Hz = 1000 frame/sec = 1/1000 = 0.001 %%%
  11. FR = 1/samp_freq; %%% sampling_rate ex) 1000 Hz = 1000 frame/sec = 1/1000 = 0.001 %%%
  12. trials_size = data_size(1,2);
  13. trials = 1:trials_size;
  14. F0_start = 0.5; %%% this number means "sec" %%%
  15. F0_end = 2.5; %%% this number means "sec" %%%
  16. mov_ave = 10; %%% this number means "msec" %%%
  18. %%%% Moving average filter %%%
  19. w_size_1 = mov_ave;
  20. span = ceil(samp_freq/(1000/w_size_1));
  21. window = ones(span,1)/span;
  22. results_movave_data = convn(newData, window, 'same'); %%% This is moving averaged data matrix %%%
  24. %%% Calculate F0 %%%
  25. f0 = mean(results_movave_data(samp_freq*F0_start+1:samp_freq*F0_end,:),1);
  27. %%% Calculate deltaF/F (%) %%%
  28. for tr = 1:length(trials);
  29. results_movave_data_deltaF(:,tr) = (((results_movave_data(:,tr)-f0(tr))/f0(tr)))*100; %%% Show deltaF/F (%) %%%
  30. end
  32. writematrix(results_movave_data_deltaF, "Processing_data.csv") %%% saving processing data %%%

Custom_Code_NCOMMS-25-05500-T.m, under MIT · at the source

Overview

Authors: Tokiharu Sato1,2, Yuka Nakamura1,2, Kana Hoshina1,2, Ken-ichi Inoue3,4, Masahiko Takada3,5, Masato Yano6,7, Hitoshi Matsuzawa8,9, Masaki Ueno1,2
ORCID iDs: Tokiharu Sato, Yuka Nakamura, Ken-ichi Inoue, Masahiko Takada, Masato Yano, Masaki Ueno
  1. Department of System Pathology for Neurological Disorders, Brain Research Institute, Niigata University, Niigata, Niigata Japan
  2. Department of Systems Neuropathology and Neural Repair, Brain Research Institute, Niigata University, Niigata, Niigata Japan
  3. Institute for the Evolutionary Origins of Human Behavior, Kyoto University, Inuyama, Aichi Japan
  4. Department of Integrative Anatomy, Graduate School of Medical Sciences and Medical School, Nagoya City University, Nagoya, Aichi Japan
  5. Department of Neurology, Graduate School of Medicine, The University of Osaka, Suita, Osaka Japan
  6. Division of Neurobiology and Anatomy, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Niigata Japan
  7. Core Research Facilities for Basic Science Research Center for Medical Science, The Jikei University School of Medicine, Minato-ku, Tokyo Japan
  8. Center for Integrated Human Brain Science, Niigata University, Niigata, Niigata Japan
  9. Center for Advanced Medicine and Clinical Research, Sapporo Hakuyokai Hospital, Sapporo, Hokkaido Japan
Institutions: Niigata University (Japan); Kyoto University (Japan); Nagoya City University (Japan); Institute for the Evolutionary Origins of Human Behavior, Kyoto University (Japan); The University of Osaka (Japan); Jikei University School of Medicine (Japan)
Journal: Nature communications, volume 17, issue 1, article 4880
Dates: received 21 January 2025; accepted 14 May 2026; published online 9 June 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41467-026-73518-x · PMID 42265101 · PMCID PMC13249867 · OpenAlex W7164027467
Open access: gold, a free copy (OpenAlex)
Status: code verified
Categories: mouse (organism), stroke (population)
Methods: Statistics, Smoothing, state filtering, decompositions, Evoked potentials, Connectivity, fMRI & imaging, Single-unit activity, calcium imaging
Keywords: Stroke, Regeneration and repair in the nervous system, Spinal cord, Neural circuits
MeSH: Astrocytes*, Interneurons*, Pyramidal Tracts*, Recovery of Function*, Stroke*, Animals, Axons, Male, Mice, Mice, Inbred C57BL, Spinal Cord (* major topic)
Topic: Neurogenesis and neuroplasticity mechanisms (Developmental Neuroscience, Neuroscience), according to OpenAlex
Funding: Takeda Science Foundation (N/A); Narishige Neuroscience Research Foundation, Ube Industries Foundation, Japan Heart Foundation Research Grant; Japan Agency for Medical Research and Development (JP21gm1210005, JP21zf0127004); Kato Memorial Bioscience Foundation (N/A); Tokyo Biochemical Research Foundation (TBRF) (N/A)
Citations: not cited yet (Europe PMC); 130 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Repository

Its files are read in the Code ↔ Paper reader above.

Zenodo 18042248

License: MIT
State: the link answers, verified on 27 September 2026
Evidence: files inventoried
Size: 1 file
Software Heritage: not checked
Found in: “Code availability”
Not found: README, license file, CITATION.cff, environment file, tests, continuous integration, documentation
Availability: 1 check, the latest on 27 September 2026: the link answers (HTTP 200)
  • 27 September 2026: the link answers (HTTP 200)
1 file
At the source:

Code availability statement

The paper has a code availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • it points to the authors' code: Zenodo 18042248

Read it in the paper: doi.org/10.1038/s41467-026-73518-x.

Tracing map

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What the map holds:

  • 1 repository of the authors' code, each at its verified commit, with its license and how the link was found in the paper;
  • 1 script, each with its path and the digest of its content;
  • no match between paragraphs and code yet;
  • neither the text of the paper nor the code itself.

Its JSON (tracing-map.json) is deposited on Zenodo with its DOI once the map is validated.

Data

Datasets cited

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1038/s41467-026-73518-x.

Versions

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 8 authors, 4 keywords, 11 MeSH terms, 5 funders, 127 references.

Cite

This paper

Sato, T., Nakamura, Y., Hoshina, K., Inoue, K.-i., Takada, M., Yano, M., Matsuzawa, H., & Ueno, M. (2026). Scg2 drives corticospinal circuit reorganization with spinal premotor interneurons and astrocytes for motor recovery after stroke in mice. Nature communications, 17(1), 4880. https://doi.org/10.1038/s41467-026-73518-x

BibTeX

@article{sato2026scg2,
author = {Sato, Tokiharu and Nakamura, Yuka and Hoshina, Kana and Inoue, Ken-ichi and Takada, Masahiko and Yano, Masato and Matsuzawa, Hitoshi and Ueno, Masaki},
title = {{Scg2 drives corticospinal circuit reorganization with spinal premotor interneurons and astrocytes for motor recovery after stroke in mice}},
journal = {Nature communications},
year = {2026},
month = jun,
volume = {17},
number = {1},
pages = {4880},
publisher = {Nature Publishing Group},
issn = {2041-1723},
doi = {10.1038/s41467-026-73518-x},
url = {https://doi.org/10.1038/s41467-026-73518-x},
pmid = {42265101},
pmcid = {PMC13249867}
}

RIS

TY - JOUR
AU - Sato, Tokiharu
AU - Nakamura, Yuka
AU - Hoshina, Kana
AU - Inoue, Ken-ichi
AU - Takada, Masahiko
AU - Yano, Masato
AU - Matsuzawa, Hitoshi
AU - Ueno, Masaki
TI - Scg2 drives corticospinal circuit reorganization with spinal premotor interneurons and astrocytes for motor recovery after stroke in mice
T2 - Nature communications
J2 - Nat Commun
PY - 2026
DA - 2026/06/09
VL - 17
IS - 1
SP - 4880
SN - 2041-1723
PB - Nature Publishing Group
DO - 10.1038/s41467-026-73518-x
UR - https://doi.org/10.1038/s41467-026-73518-x
LA - en
ER -

CSL-JSON

{
"id": "10.1038/s41467-026-73518-x",
"type": "article-journal",
"title": "Scg2 drives corticospinal circuit reorganization with spinal premotor interneurons and astrocytes for motor recovery after stroke in mice",
"container-title": "Nature communications",
"author": [
{
"family": "Sato",
"given": "Tokiharu"
},
{
"family": "Nakamura",
"given": "Yuka"
},
{
"family": "Hoshina",
"given": "Kana"
},
{
"family": "Inoue",
"given": "Ken-ichi"
},
{
"family": "Takada",
"given": "Masahiko"
},
{
"family": "Yano",
"given": "Masato"
},
{
"family": "Matsuzawa",
"given": "Hitoshi"
},
{
"family": "Ueno",
"given": "Masaki"
}
],
"container-title-short": "Nat Commun",
"volume": "17",
"issue": "1",
"page": "4880",
"DOI": "10.1038/s41467-026-73518-x",
"PMID": "42265101",
"PMCID": "PMC13249867",
"ISSN": "2041-1723",
"publisher": "Nature Publishing Group",
"URL": "https://doi.org/10.1038/s41467-026-73518-x",
"language": "en",
"issued": {
"date-parts": [
[
2026,
6,
9
]
]
}
}

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