OSCR

Anisodine hydrobromide targets matk and prevents delayed rtPA thrombolysis-induced vasogenic cerebral edema in ischemic stroke.

Overview

Authors: Song Guo1,2,3,4,5, An-Qing Li1,2,3,4,5, Fan-Kai Chen1,2,3,4,5, Ding-Zhou Weng1,2,3,4,5, Zheng Wang1,2,3,4,5, Chong Yang1,2,3,4,5, Yu-Jie Zhang1,2,3,4,5, Yi Zhang1,2,3,4,5, Xin Chang1,2,3,4,5, Hong-Biao Liang1,2,3,4,5, Jian Liu1,2,3,4,5
ORCID iDs: Jian Liu
  1. Department of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, Peking University, Beijing, China
  2. Academy of Integration of Chinese and Western Medicine, Peking University Health Science Center, Beijing, China
  3. The Key Discipline for Integration of Chinese and Western Basic Medicine (Microcirculation) of the National Administration of Traditional Chinese Medicine, Beijing, China
  4. Key Laboratory of Stasis and Phlegm, State Administration of Traditional Chinese Medicine of the People’s Republic of China, Beijing, China
  5. Beijing Microvascular Institute of Integration of Chinese and Western Medicine, Beijing, China
Institutions: Peking University (China); State Administration of Traditional Chinese Medicine of the People's Republic of China (China)
Journal: Nature communications, volume 17, issue 1, article 7250
Dates: received 10 July 2025; accepted 27 May 2026; published online 8 June 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41467-026-73995-0 · PMID 42259802 · PMCID PMC13396228 · OpenAlex W7163921535
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: human (organism), mouse (organism), stroke (population)
Methods: Statistics, Smoothing, state filtering, decompositions, Physiology & signal measures
Keywords: Target identification, Stroke
MeSH: Brain Edema*, Ischemic Stroke*, Thrombolytic Therapy*, Tissue Plasminogen Activator*, Animals, Blood-Brain Barrier, Disease Models, Animal, Humans, Male, Mice, Mice, Inbred C57BL, Protein-Tyrosine Kinases, Signal Transduction, src-Family Kinases (* major topic)
Topic: Acute Ischemic Stroke Management (Epidemiology, Medicine), according to OpenAlex
Citations: cited by 1 paper (Europe PMC); 46 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

The paper links to its data, not to its authors' code: see the Data section.

The paper's code and data availability statement is in the Data section.

Tracing map

A tracing map links a paper to the code its authors published: this paper has none, so it has no map.

Data

Datasets cited

Code and data availability statement

The paper has a code and data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1038/s41467-026-73995-0.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 11 authors, 2 keywords, 14 MeSH terms, 46 references.

Cite

This paper

Guo, S., Li, A.-Q., Chen, F.-K., Weng, D.-Z., Wang, Z., Yang, C., Zhang, Y.-J., Zhang, Y., Chang, X., Liang, H.-B., & Liu, J. (2026). Anisodine hydrobromide targets matk and prevents delayed rtPA thrombolysis-induced vasogenic cerebral edema in ischemic stroke. Nature communications, 17(1), 7250. https://doi.org/10.1038/s41467-026-73995-0

BibTeX

@article{guo2026anisodine,
author = {Guo, Song and Li, An-Qing and Chen, Fan-Kai and Weng, Ding-Zhou and Wang, Zheng and Yang, Chong and Zhang, Yu-Jie and Zhang, Yi and Chang, Xin and Liang, Hong-Biao and Liu, Jian},
title = {{Anisodine hydrobromide targets matk and prevents delayed rtPA thrombolysis-induced vasogenic cerebral edema in ischemic stroke}},
journal = {Nature communications},
year = {2026},
month = jun,
volume = {17},
number = {1},
pages = {7250},
publisher = {Nature Publishing Group},
issn = {2041-1723},
doi = {10.1038/s41467-026-73995-0},
url = {https://doi.org/10.1038/s41467-026-73995-0},
pmid = {42259802},
pmcid = {PMC13396228}
}

RIS

TY - JOUR
AU - Guo, Song
AU - Li, An-Qing
AU - Chen, Fan-Kai
AU - Weng, Ding-Zhou
AU - Wang, Zheng
AU - Yang, Chong
AU - Zhang, Yu-Jie
AU - Zhang, Yi
AU - Chang, Xin
AU - Liang, Hong-Biao
AU - Liu, Jian
TI - Anisodine hydrobromide targets matk and prevents delayed rtPA thrombolysis-induced vasogenic cerebral edema in ischemic stroke
T2 - Nature communications
J2 - Nat Commun
PY - 2026
DA - 2026/06/08
VL - 17
IS - 1
SP - 7250
SN - 2041-1723
PB - Nature Publishing Group
DO - 10.1038/s41467-026-73995-0
UR - https://doi.org/10.1038/s41467-026-73995-0
LA - en
ER -

CSL-JSON

{
"id": "10.1038/s41467-026-73995-0",
"type": "article-journal",
"title": "Anisodine hydrobromide targets matk and prevents delayed rtPA thrombolysis-induced vasogenic cerebral edema in ischemic stroke",
"container-title": "Nature communications",
"author": [
{
"family": "Guo",
"given": "Song"
},
{
"family": "Li",
"given": "An-Qing"
},
{
"family": "Chen",
"given": "Fan-Kai"
},
{
"family": "Weng",
"given": "Ding-Zhou"
},
{
"family": "Wang",
"given": "Zheng"
},
{
"family": "Yang",
"given": "Chong"
},
{
"family": "Zhang",
"given": "Yu-Jie"
},
{
"family": "Zhang",
"given": "Yi"
},
{
"family": "Chang",
"given": "Xin"
},
{
"family": "Liang",
"given": "Hong-Biao"
},
{
"family": "Liu",
"given": "Jian"
}
],
"container-title-short": "Nat Commun",
"volume": "17",
"issue": "1",
"page": "7250",
"DOI": "10.1038/s41467-026-73995-0",
"PMID": "42259802",
"PMCID": "PMC13396228",
"ISSN": "2041-1723",
"publisher": "Nature Publishing Group",
"URL": "https://doi.org/10.1038/s41467-026-73995-0",
"language": "en",
"issued": {
"date-parts": [
[
2026,
6,
8
]
]
}
}

Similar papers

The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.

[1] doi:10.1038/s41598-026-48239-2 [code]
LigGen-a GEN-AI based ligand generation approach for de-novo drug design.
Journal: Scientific reports
In common: 2 references
[2] doi:10.3390/biomedicines14050998 [code]
Integrative Multi-Omics and Machine Learning Analysis Identifies Therapeutic Targets and Drug Repurposing Candidates for Alzheimer's Disease.
Journal: Biomedicines
In common: 2 references
[3] doi:10.1186/s13293-026-00941-6
Prenatal BPA exposure perturbs RNA-binding protein-mediated splicing regulation and synaptogenesis in the developing cerebellum in a sex-dependent manner.
Journal: Biology of sex differences
In common: 2 references
[4] doi:10.1186/s12929-026-01271-w
Lack of cortistatin drives neuroimmune and vascular dysfunction in brain ischemia.
Journal: Journal of biomedical science
In common: stroke, mouse, 1 reference
[5] doi:10.1021/acsptsci.5c00821
Blood-Brain Barrier (BBB)-Penetrable Androgen Receptor (AR) Degrader as a Potential Therapeutic Agent for Glioblastoma.
Journal: ACS pharmacology & translational science
In common: 2 references
[6] doi:10.1161/jaha.125.046088 [code]
Systematic Identification of Therapeutic Targets and Repurposed Drugs for Stroke: From Genome Causal Analysis to Multilevel Validation.
Journal: Journal of the American Heart Association
In common: stroke, mouse, 1 reference
[7] doi:10.1038/s41598-026-66143-7
Recombinant CXCL16 reduces brain injury by modulating microglial phenotype and attenuating apoptosis in acute ischemic stroke.
Journal: Scientific reports
In common: stroke, mouse, 1 reference
[8] doi:10.1016/j.neurot.2026.e00977
Exosome-mediated delivery of 3-n-butylphthalide rescues microglial energy crisis and ameliorates neuroinflammation in ischemic stroke.
Journal: Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
In common: stroke, mouse, 1 reference
[9] doi:10.1016/j.redox.2026.104210
Vespakinin-M delineates an AMPK/mTOR-arginine-TCA cycle axis to act as an immunometabolic switch in post-stroke microglia.
Journal: Redox biology
In common: stroke, mouse, 1 reference
[10] doi:10.1016/j.isci.2026.115779
Propranolol alleviates cerebral infarction through the β2-AR-mediated ERK/NLRP3 pathway.
Journal: iScience
In common: stroke, mouse, 1 reference

Contribute

The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.

Sign in with ORCID to claim this paper as one of its authors, correct its record or validate its tracing map: when the paper's metadata lists your ORCID iD, you are recognized at once. Maintainers of its code: sign in with GitHub, then claim the repository on your account page.

Request its removal

To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).

Discussion, reproductions, activity

Discussion: questions and error reports about this paper and its code, from signed-in readers and its authors. It opens with sign-in.

Reproductions: reports from readers who ran the authors' code: what they reproduced, with which environment, commit and data. It opens with sign-in.

Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.