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The role of supraoptic hypothalamic arginine vasopressin neurons in aging-associated water balance and thermoregulatory deficits in male mice.

Overview

Authors: Nancy Morones1,2, Predrag Jovanovic1,2, Anna M Sanetra1,2, Kaitlyn Jang1,2, Nareg Keshishian1,2, Zhihan C Cui1,2, Edward Novinbakht1,2, Joshua J Breunig1,2,3, Anders H Berg4, Tamar Pirtskhalava5, Selim Chaib5, S Ananth Karumanchi6, Tamar Tchkonia5, Katlin Silm1,2,7, James L Kirkland5, Celine E Riera1,2,7
ORCID iDs: Nancy Morones, Predrag Jovanovic, Anna M Sanetra, Selim Chaib, S Ananth Karumanchi, Tamar Tchkonia, Katlin Silm, Celine E Riera
  1. Center for Neural Science and Medicine, Department of Biomedical Sciences, Cedars-Sinai Health Sciences University, Los Angeles, CA USA
  2. Board of Governors Regenerative Medicine Institute, Cedars-Sinai Health Sciences University, Los Angeles, CA USA
  3. Cancer Center, Cedars-Sinai Health Sciences University, Los Angeles, CA USA
  4. Department of Pathology, Cedars Sinai Health Sciences University, Los Angeles, CA USA
  5. Center for Advanced Gerotherapeutics, Division of Endocrinology, Diabetes & Metabolism, Department of Medicine, Cedars-Sinai Health Sciences University, Los Angeles, CA USA
  6. Department of Medicine, Cedars-Sinai Health Sciences University, Los Angeles, CA USA
  7. Department of Neurology, Cedars-Sinai Health Sciences University, Los Angeles, CA USA
Institutions: Cedars-Sinai Medical Center (United States)
Journal: Nature communications, volume 17, issue 1, article 8048
Dates: received 5 November 2025; accepted 11 June 2026; published online 27 June 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41467-026-74819-x · PMID 42364986 · PMCID PMC13454442 · OpenAlex W7166342635
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: mouse (organism), cellular / molecular (subfield)
Methods: Connectivity, Statistics, Smoothing, state filtering, decompositions, Graphs, Machine learning, fMRI & imaging, Single-unit activity, calcium imaging
Keywords: Cognitive ageing, Hypothalamus, Molecular neuroscience
MeSH: Aging*, Arginine Vasopressin*, Body Temperature Regulation*, Neurons*, Supraoptic Nucleus*, Water-Electrolyte Balance*, Animals, Energy Metabolism, Homeostasis, Male, Mice, Mice, Inbred C57BL, Receptors, Vasopressin (* major topic)
Topic: Neuroendocrine regulation and behavior (Social Psychology, Psychology), according to OpenAlex
Funding: Larry L. Hillblom Foundation (Start-up Grant); NIA NIH HHS (R37 AG013925, RF1 AG091203); U.S. Department of Health & Human Services | NIH | National Institute on Aging (R37AG013925, RF1AG091203); California Institute for Regenerative Medicine (EDUC-12751); U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) (RF1AG091203, R37AG013925)
Citations: cited by 1 paper (Europe PMC); 77 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Datasets cited

Data availability statement

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Read it in the paper: doi.org/10.1038/s41467-026-74819-x.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 16 authors, 3 keywords, 13 MeSH terms, 5 funders, 76 references.

Cite

This paper

Morones, N., Jovanovic, P., Sanetra, A. M., Jang, K., Keshishian, N., Cui, Z. C., Novinbakht, E., Breunig, J. J., Berg, A. H., Pirtskhalava, T., Chaib, S., Karumanchi, S. A., Tchkonia, T., Silm, K., Kirkland, J. L., & Riera, C. E. (2026). The role of supraoptic hypothalamic arginine vasopressin neurons in aging-associated water balance and thermoregulatory deficits in male mice. Nature communications, 17(1), 8048. https://doi.org/10.1038/s41467-026-74819-x

BibTeX

@article{morones2026role,
author = {Morones, Nancy and Jovanovic, Predrag and Sanetra, Anna M and Jang, Kaitlyn and Keshishian, Nareg and Cui, Zhihan C and Novinbakht, Edward and Breunig, Joshua J and Berg, Anders H and Pirtskhalava, Tamar and Chaib, Selim and Karumanchi, S Ananth and Tchkonia, Tamar and Silm, Katlin and Kirkland, James L and Riera, Celine E},
title = {{The role of supraoptic hypothalamic arginine vasopressin neurons in aging-associated water balance and thermoregulatory deficits in male mice}},
journal = {Nature communications},
year = {2026},
month = jun,
volume = {17},
number = {1},
pages = {8048},
publisher = {Nature Publishing Group},
issn = {2041-1723},
doi = {10.1038/s41467-026-74819-x},
url = {https://doi.org/10.1038/s41467-026-74819-x},
pmid = {42364986},
pmcid = {PMC13454442}
}

RIS

TY - JOUR
AU - Morones, Nancy
AU - Jovanovic, Predrag
AU - Sanetra, Anna M
AU - Jang, Kaitlyn
AU - Keshishian, Nareg
AU - Cui, Zhihan C
AU - Novinbakht, Edward
AU - Breunig, Joshua J
AU - Berg, Anders H
AU - Pirtskhalava, Tamar
AU - Chaib, Selim
AU - Karumanchi, S Ananth
AU - Tchkonia, Tamar
AU - Silm, Katlin
AU - Kirkland, James L
AU - Riera, Celine E
TI - The role of supraoptic hypothalamic arginine vasopressin neurons in aging-associated water balance and thermoregulatory deficits in male mice
T2 - Nature communications
J2 - Nat Commun
PY - 2026
DA - 2026/06/27
VL - 17
IS - 1
SP - 8048
SN - 2041-1723
PB - Nature Publishing Group
DO - 10.1038/s41467-026-74819-x
UR - https://doi.org/10.1038/s41467-026-74819-x
LA - en
ER -

CSL-JSON

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