OSCR

Engineered zwitterion-nanodelivery for precision targeting of brain metastases.

Overview

Authors: Haibao Peng1,2, Youming Zeng1,2, Yang Huang1,2, Chenyu Lin1,2, Zeyu Lei1,2, Peixin Sun2, Jiahui Yang1,2, Shaoqi Sheng3, Yuxin Huang3, Xiaohui Li1,2, Jiaxu Zhao2, Rui Zeng2, Cheng Li1,2, Wanqi Yang1,2, Xiangjie Di4, Sisi He5, Yongsheng Wang4, Hanting Yang2,6, Wuli Yang3, Yudan Chi1,2
ORCID iDs: Haibao Peng, Rui Zeng, Sisi He, Hanting Yang, Wuli Yang, Yudan Chi
  1. Department of Radiology, Huadong Hospital, Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai Institute of Geriatrics and Gerontology, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University,Shanghai, China
  2. Department of Neurosurgery, Huashan Hospital, Institute for Translational Brain Research, MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases, Fudan University,Shanghai, China
  3. State Key Laboratory of Molecular Engineering of Polymers and Department of Macromolecular Science, Fudan University,Shanghai, China
  4. Thoracic Oncology Ward, Cancer Center, and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University,Chengdu, China
  5. Department of Oncology, The Second Affiliated Hospital of Zunyi Medical University,Guizhou, China
  6. Zhongshan Hospital, Fudan University,Shanghai, China
Institutions: Frontiers Center for Brain Science of the Ministry of Education (China); Fudan University (China); State Key Laboratory of Biotherapy; Zunyi Medical University (China)
Journal: Nature communications, volume 17, issue 1, article 8483
Dates: received 14 July 2025; accepted 14 June 2026; published online 9 July 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41467-026-74888-y · PMID 42425968 · PMCID PMC13478204 · OpenAlex W7167792804
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: human (organism), mouse (organism), other condition (population)
Methods: Statistics, Evoked potentials
Keywords: CNS cancer, Biomedical materials, Drug delivery, Chemotherapy
MeSH: Betaine*, Brain Neoplasms*, Drug Delivery Systems*, Nanoparticles*, Acrylamides, Aniline Compounds, Animals, Antineoplastic Agents, Blood-Brain Barrier, Cell Line, Tumor, Cisplatin, Female, Humans, Indoles, Mice, Mice, Nude, Tumor Microenvironment, Xenograft Model Antitumor Assays (* major topic)
Topic: Nanoplatforms for cancer theranostics (Biomedical Engineering, Engineering), according to OpenAlex
Funding: Chinese Ministry of Science and Technology | Department of S and T for Social Development (Department of S&T for Social Development) (2022YFA1106400); National Natural Science Foundation of China (National Science Foundation of China) (82573109, 82273304, 51933002, 82403445, 32171216, 52373130,51933002); he National Science and Technology Innovation 2030 Major Projects of China (STI2030-Major Projects 2022ZD0212600, H.Y.)
Citations: not cited yet (Europe PMC); 72 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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The paper's code and data availability statement is in the Data section.

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Data

Datasets cited

Code and data availability statement

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Read it in the paper: doi.org/10.1038/s41467-026-74888-y.

Versions

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 20 authors, 4 keywords, 18 MeSH terms, 3 funders, 72 references.

Cite

This paper

Peng, H., Zeng, Y., Huang, Y., Lin, C., Lei, Z., Sun, P., Yang, J., Sheng, S., Huang, Y., Li, X., Zhao, J., Zeng, R., Li, C., Yang, W., Di, X., He, S., Wang, Y., Yang, H., Yang, W., & Chi, Y. (2026). Engineered zwitterion-nanodelivery for precision targeting of brain metastases. Nature communications, 17(1), 8483. https://doi.org/10.1038/s41467-026-74888-y

BibTeX

@article{peng2026engineered,
author = {Peng, Haibao and Zeng, Youming and Huang, Yang and Lin, Chenyu and Lei, Zeyu and Sun, Peixin and Yang, Jiahui and Sheng, Shaoqi and Huang, Yuxin and Li, Xiaohui and Zhao, Jiaxu and Zeng, Rui and Li, Cheng and Yang, Wanqi and Di, Xiangjie and He, Sisi and Wang, Yongsheng and Yang, Hanting and Yang, Wuli and Chi, Yudan},
title = {{Engineered zwitterion-nanodelivery for precision targeting of brain metastases}},
journal = {Nature communications},
year = {2026},
month = jul,
volume = {17},
number = {1},
pages = {8483},
publisher = {Nature Publishing Group},
issn = {2041-1723},
doi = {10.1038/s41467-026-74888-y},
url = {https://doi.org/10.1038/s41467-026-74888-y},
pmid = {42425968},
pmcid = {PMC13478204}
}

RIS

TY - JOUR
AU - Peng, Haibao
AU - Zeng, Youming
AU - Huang, Yang
AU - Lin, Chenyu
AU - Lei, Zeyu
AU - Sun, Peixin
AU - Yang, Jiahui
AU - Sheng, Shaoqi
AU - Huang, Yuxin
AU - Li, Xiaohui
AU - Zhao, Jiaxu
AU - Zeng, Rui
AU - Li, Cheng
AU - Yang, Wanqi
AU - Di, Xiangjie
AU - He, Sisi
AU - Wang, Yongsheng
AU - Yang, Hanting
AU - Yang, Wuli
AU - Chi, Yudan
TI - Engineered zwitterion-nanodelivery for precision targeting of brain metastases
T2 - Nature communications
J2 - Nat Commun
PY - 2026
DA - 2026/07/09
VL - 17
IS - 1
SP - 8483
SN - 2041-1723
PB - Nature Publishing Group
DO - 10.1038/s41467-026-74888-y
UR - https://doi.org/10.1038/s41467-026-74888-y
LA - en
ER -

CSL-JSON

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